Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers

Autores
Lendez, Pamela Anahí; Martinez Cuesta, Lucia; Nieto Farías, María Victoria; Shen, Hua Min; Dolcini, Guillermina Laura; Buehring, Gertrude Case; Ceriani, Maria Carolina
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Bovine leukemia virus (BLV) causes enzootic bovine leukemia, andis closely related to human T-lymphotropic virus type 1. It expresses microRNAs ofunknown function and codes Tax, the protein that mediates malignant transformation.BLV is capable of infecting B- and T-lymphocytes, endothelial cells, and mammaryepithelial cells of cattle. Several studies demonstrated the presence of BLV DNA inhuman tissue, and it is significantly associated with breast cancer in case-control studiesusing in situ PCR, a highly sensitive and specific technique. The current study was thefirst report of BLV DNA detection by in situ PCR in tissue from Argentinian femaleswith a diagnosis of breast cancer.Methods: In situ PCR was done to detect BLV DNA in 85 human FFPE breast cancertissue samples. The association of BLV DNA and expression of Ki67 and Her-2 wasassessed.Results: BLV DNA presence could be determined in 22.6% of the analyzed samples, andits presence was associated with an increase of the expression and prognosis markers Ki67(P=0.009) and HER-2 (P=0.044) determined by conventional immunohistochemistry.No statistical significance was observed between the presence or absence of hormonalreceptors and the presence of BLV DNA.Conclusions: The obtained results support the idea that BLV might play a role inmalignant tissue transformation.
Fil: Lendez, Pamela Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Martinez Cuesta, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Nieto Farías, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Shen, Hua Min. University of California at Berkeley; Estados Unidos
Fil: Dolcini, Guillermina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Buehring, Gertrude Case. University of California at Berkeley; Estados Unidos
Fil: Ceriani, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Materia
BOVINE LEUKEMIA VIRUS
PROGNOSIS
CELL PROLIFERATION
HUMAN BREAST CANCER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93895

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network_name_str CONICET Digital (CONICET)
spelling Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis MarkersLendez, Pamela AnahíMartinez Cuesta, LuciaNieto Farías, María VictoriaShen, Hua MinDolcini, Guillermina LauraBuehring, Gertrude CaseCeriani, Maria CarolinaBOVINE LEUKEMIA VIRUSPROGNOSISCELL PROLIFERATIONHUMAN BREAST CANCERhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Bovine leukemia virus (BLV) causes enzootic bovine leukemia, andis closely related to human T-lymphotropic virus type 1. It expresses microRNAs ofunknown function and codes Tax, the protein that mediates malignant transformation.BLV is capable of infecting B- and T-lymphocytes, endothelial cells, and mammaryepithelial cells of cattle. Several studies demonstrated the presence of BLV DNA inhuman tissue, and it is significantly associated with breast cancer in case-control studiesusing in situ PCR, a highly sensitive and specific technique. The current study was thefirst report of BLV DNA detection by in situ PCR in tissue from Argentinian femaleswith a diagnosis of breast cancer.Methods: In situ PCR was done to detect BLV DNA in 85 human FFPE breast cancertissue samples. The association of BLV DNA and expression of Ki67 and Her-2 wasassessed.Results: BLV DNA presence could be determined in 22.6% of the analyzed samples, andits presence was associated with an increase of the expression and prognosis markers Ki67(P=0.009) and HER-2 (P=0.044) determined by conventional immunohistochemistry.No statistical significance was observed between the presence or absence of hormonalreceptors and the presence of BLV DNA.Conclusions: The obtained results support the idea that BLV might play a role inmalignant tissue transformation.Fil: Lendez, Pamela Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Martinez Cuesta, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Nieto Farías, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Shen, Hua Min. University of California at Berkeley; Estados UnidosFil: Dolcini, Guillermina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Buehring, Gertrude Case. University of California at Berkeley; Estados UnidosFil: Ceriani, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaMultidisciplinary Cancer Investigation2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93895Lendez, Pamela Anahí; Martinez Cuesta, Lucia; Nieto Farías, María Victoria; Shen, Hua Min; Dolcini, Guillermina Laura; et al.; Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers; Multidisciplinary Cancer Investigation; Multidisciplinary Cancer Investigation; 2; 10-2018; 16-242476-4922CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.30699/acadpub.mci.4.16info:eu-repo/semantics/altIdentifier/url/http://mcijournal.com/article-1-208-en.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:22Zoai:ri.conicet.gov.ar:11336/93895instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:22.629CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
title Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
spellingShingle Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
Lendez, Pamela Anahí
BOVINE LEUKEMIA VIRUS
PROGNOSIS
CELL PROLIFERATION
HUMAN BREAST CANCER
title_short Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
title_full Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
title_fullStr Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
title_full_unstemmed Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
title_sort Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
dc.creator.none.fl_str_mv Lendez, Pamela Anahí
Martinez Cuesta, Lucia
Nieto Farías, María Victoria
Shen, Hua Min
Dolcini, Guillermina Laura
Buehring, Gertrude Case
Ceriani, Maria Carolina
author Lendez, Pamela Anahí
author_facet Lendez, Pamela Anahí
Martinez Cuesta, Lucia
Nieto Farías, María Victoria
Shen, Hua Min
Dolcini, Guillermina Laura
Buehring, Gertrude Case
Ceriani, Maria Carolina
author_role author
author2 Martinez Cuesta, Lucia
Nieto Farías, María Victoria
Shen, Hua Min
Dolcini, Guillermina Laura
Buehring, Gertrude Case
Ceriani, Maria Carolina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BOVINE LEUKEMIA VIRUS
PROGNOSIS
CELL PROLIFERATION
HUMAN BREAST CANCER
topic BOVINE LEUKEMIA VIRUS
PROGNOSIS
CELL PROLIFERATION
HUMAN BREAST CANCER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Bovine leukemia virus (BLV) causes enzootic bovine leukemia, andis closely related to human T-lymphotropic virus type 1. It expresses microRNAs ofunknown function and codes Tax, the protein that mediates malignant transformation.BLV is capable of infecting B- and T-lymphocytes, endothelial cells, and mammaryepithelial cells of cattle. Several studies demonstrated the presence of BLV DNA inhuman tissue, and it is significantly associated with breast cancer in case-control studiesusing in situ PCR, a highly sensitive and specific technique. The current study was thefirst report of BLV DNA detection by in situ PCR in tissue from Argentinian femaleswith a diagnosis of breast cancer.Methods: In situ PCR was done to detect BLV DNA in 85 human FFPE breast cancertissue samples. The association of BLV DNA and expression of Ki67 and Her-2 wasassessed.Results: BLV DNA presence could be determined in 22.6% of the analyzed samples, andits presence was associated with an increase of the expression and prognosis markers Ki67(P=0.009) and HER-2 (P=0.044) determined by conventional immunohistochemistry.No statistical significance was observed between the presence or absence of hormonalreceptors and the presence of BLV DNA.Conclusions: The obtained results support the idea that BLV might play a role inmalignant tissue transformation.
Fil: Lendez, Pamela Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Martinez Cuesta, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Nieto Farías, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Shen, Hua Min. University of California at Berkeley; Estados Unidos
Fil: Dolcini, Guillermina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Buehring, Gertrude Case. University of California at Berkeley; Estados Unidos
Fil: Ceriani, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
description Introduction: Bovine leukemia virus (BLV) causes enzootic bovine leukemia, andis closely related to human T-lymphotropic virus type 1. It expresses microRNAs ofunknown function and codes Tax, the protein that mediates malignant transformation.BLV is capable of infecting B- and T-lymphocytes, endothelial cells, and mammaryepithelial cells of cattle. Several studies demonstrated the presence of BLV DNA inhuman tissue, and it is significantly associated with breast cancer in case-control studiesusing in situ PCR, a highly sensitive and specific technique. The current study was thefirst report of BLV DNA detection by in situ PCR in tissue from Argentinian femaleswith a diagnosis of breast cancer.Methods: In situ PCR was done to detect BLV DNA in 85 human FFPE breast cancertissue samples. The association of BLV DNA and expression of Ki67 and Her-2 wasassessed.Results: BLV DNA presence could be determined in 22.6% of the analyzed samples, andits presence was associated with an increase of the expression and prognosis markers Ki67(P=0.009) and HER-2 (P=0.044) determined by conventional immunohistochemistry.No statistical significance was observed between the presence or absence of hormonalreceptors and the presence of BLV DNA.Conclusions: The obtained results support the idea that BLV might play a role inmalignant tissue transformation.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93895
Lendez, Pamela Anahí; Martinez Cuesta, Lucia; Nieto Farías, María Victoria; Shen, Hua Min; Dolcini, Guillermina Laura; et al.; Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers; Multidisciplinary Cancer Investigation; Multidisciplinary Cancer Investigation; 2; 10-2018; 16-24
2476-4922
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93895
identifier_str_mv Lendez, Pamela Anahí; Martinez Cuesta, Lucia; Nieto Farías, María Victoria; Shen, Hua Min; Dolcini, Guillermina Laura; et al.; Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers; Multidisciplinary Cancer Investigation; Multidisciplinary Cancer Investigation; 2; 10-2018; 16-24
2476-4922
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
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dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Cancer Investigation
publisher.none.fl_str_mv Multidisciplinary Cancer Investigation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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