Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance

Autores
Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; Frechtel, G.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.
Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
Socs7
Insulin Resistance
Tagsnps
Inflammation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8049
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8049
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistanceTellechea, Mariana LorenaPenas Steinhardt, AlbertoRodriguez, G.Taverna, Mariano JavierPoskus, EdgardoFrechtel, G.Socs7Insulin ResistanceTagsnpsInflammationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; ArgentinaFil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; ArgentinaFil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaElsevier2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8049Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; et al.; Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance; Elsevier; Nutrition Metabolism And Cardiovascular Diseases; 23; 5; 3-2012; 424-4310939-4753enginfo:eu-repo/semantics/altIdentifier/url/http://www.nmcd-journal.com/article/S0939-4753(11)00253-5/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.numecd.2011.10.005info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0939475311002535info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:15:24Zoai:ri.conicet.gov.ar:11336/8049instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:15:25.3CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
title Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
spellingShingle Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
Tellechea, Mariana Lorena
Socs7
Insulin Resistance
Tagsnps
Inflammation
title_short Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
title_full Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
title_fullStr Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
title_full_unstemmed Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
title_sort Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
dc.creator.none.fl_str_mv Tellechea, Mariana Lorena
Penas Steinhardt, Alberto
Rodriguez, G.
Taverna, Mariano Javier
Poskus, Edgardo
Frechtel, G.
author Tellechea, Mariana Lorena
author_facet Tellechea, Mariana Lorena
Penas Steinhardt, Alberto
Rodriguez, G.
Taverna, Mariano Javier
Poskus, Edgardo
Frechtel, G.
author_role author
author2 Penas Steinhardt, Alberto
Rodriguez, G.
Taverna, Mariano Javier
Poskus, Edgardo
Frechtel, G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Socs7
Insulin Resistance
Tagsnps
Inflammation
topic Socs7
Insulin Resistance
Tagsnps
Inflammation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.
Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8049
Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; et al.; Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance; Elsevier; Nutrition Metabolism And Cardiovascular Diseases; 23; 5; 3-2012; 424-431
0939-4753
url http://hdl.handle.net/11336/8049
identifier_str_mv Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; et al.; Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance; Elsevier; Nutrition Metabolism And Cardiovascular Diseases; 23; 5; 3-2012; 424-431
0939-4753
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nmcd-journal.com/article/S0939-4753(11)00253-5/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.numecd.2011.10.005
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0939475311002535
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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