Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance
- Autores
- Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; Frechtel, G.
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.
Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina
Fil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina - Materia
-
Socs7
Insulin Resistance
Tagsnps
Inflammation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/8049
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Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistanceTellechea, Mariana LorenaPenas Steinhardt, AlbertoRodriguez, G.Taverna, Mariano JavierPoskus, EdgardoFrechtel, G.Socs7Insulin ResistanceTagsnpsInflammationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; ArgentinaFil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; ArgentinaFil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaElsevier2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8049Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; et al.; Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance; Elsevier; Nutrition Metabolism And Cardiovascular Diseases; 23; 5; 3-2012; 424-4310939-4753enginfo:eu-repo/semantics/altIdentifier/url/http://www.nmcd-journal.com/article/S0939-4753(11)00253-5/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.numecd.2011.10.005info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0939475311002535info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:34Zoai:ri.conicet.gov.ar:11336/8049instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:34.896CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
title |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
spellingShingle |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance Tellechea, Mariana Lorena Socs7 Insulin Resistance Tagsnps Inflammation |
title_short |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
title_full |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
title_fullStr |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
title_full_unstemmed |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
title_sort |
Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance |
dc.creator.none.fl_str_mv |
Tellechea, Mariana Lorena Penas Steinhardt, Alberto Rodriguez, G. Taverna, Mariano Javier Poskus, Edgardo Frechtel, G. |
author |
Tellechea, Mariana Lorena |
author_facet |
Tellechea, Mariana Lorena Penas Steinhardt, Alberto Rodriguez, G. Taverna, Mariano Javier Poskus, Edgardo Frechtel, G. |
author_role |
author |
author2 |
Penas Steinhardt, Alberto Rodriguez, G. Taverna, Mariano Javier Poskus, Edgardo Frechtel, G. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Socs7 Insulin Resistance Tagsnps Inflammation |
topic |
Socs7 Insulin Resistance Tagsnps Inflammation |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders. Fil: Tellechea, Mariana Lorena. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina Fil: Rodriguez, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Taverna, Mariano Javier. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Poskus, Edgardo. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina Fil: Frechtel, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina |
description |
Background and Aims: Specific Suppressor Of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results: 780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (P = 0.005) and abdominal obesity (P = 0.002) and allele C carriers showed, in comparison with TT-carriers, lower BMI (P = 0.001) and waist circumference (P = 0.001). rs8074124CC- carriers showed lower fasting insulin (P = 0.017) and HOMA-IR (P = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (P = 0.009) and hypertriglyceridemic waist (P = 0.006). rs12051836CC- carriers showed lower fasting insulin (P = 0.043) and HOMA-IR (P = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (P = 0.026) and HDL-C (P = 0.014) as a continuous variable. Conclusion: We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/8049 Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; et al.; Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance; Elsevier; Nutrition Metabolism And Cardiovascular Diseases; 23; 5; 3-2012; 424-431 0939-4753 |
url |
http://hdl.handle.net/11336/8049 |
identifier_str_mv |
Tellechea, Mariana Lorena; Penas Steinhardt, Alberto; Rodriguez, G.; Taverna, Mariano Javier; Poskus, Edgardo; et al.; Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance; Elsevier; Nutrition Metabolism And Cardiovascular Diseases; 23; 5; 3-2012; 424-431 0939-4753 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.nmcd-journal.com/article/S0939-4753(11)00253-5/abstract info:eu-repo/semantics/altIdentifier/doi/10.1016/j.numecd.2011.10.005 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0939475311002535 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |