Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer

Autores
Villanueva, María Emilia; González, Joaquín Antonio; Rodríguez Castellón, E.; Teves, S.; Copello, Guillermo Javier
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antimicrobial polyvinyl chloride (PVC) plastic was obtained by covalent bonding of poly hexamethylenediamine guanidine hydrochloride (PHMG), a guanidine based antimicrobial polymer. This was achieved by grafting mercaptopropyltrimethoxysilane onto PVC, followed by aminopropyltriethoxysilane. Glutaraldehyde is a bifunctional crosslinker that was bonded to the free amine groups found in the treated PVC on one side and PHMG on the other. The treated PVC samples were characterized by FT-IR and XPS, showing that the PVC samples were successfully modified. Energy Dispersive X-ray spectroscopy showed the spatial distribution of the elements Si and S, indicating that the coatings were homogeneous. The resulting PVC samples showed high antimicrobial activity against Gram-positive and Gram-negative bacteria. Furthermore, the biofilm formation was negligible in comparison with the untreated material. The coating elusion assay indicated that its antimicrobial ability was achieved via direct contact rather than a controlled release mechanism.
Fil: Villanueva, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: González, Joaquín Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Rodríguez Castellón, E.. Universidad de Málaga; España
Fil: Teves, S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
Antimicrobial Coating
Non-Leaching Coating
Poly Hexamethylenediamine Guanidine Hydrochloride
Pvc
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38920
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymerVillanueva, María EmiliaGonzález, Joaquín AntonioRodríguez Castellón, E.Teves, S.Copello, Guillermo JavierAntimicrobial CoatingNon-Leaching CoatingPoly Hexamethylenediamine Guanidine HydrochloridePvchttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Antimicrobial polyvinyl chloride (PVC) plastic was obtained by covalent bonding of poly hexamethylenediamine guanidine hydrochloride (PHMG), a guanidine based antimicrobial polymer. This was achieved by grafting mercaptopropyltrimethoxysilane onto PVC, followed by aminopropyltriethoxysilane. Glutaraldehyde is a bifunctional crosslinker that was bonded to the free amine groups found in the treated PVC on one side and PHMG on the other. The treated PVC samples were characterized by FT-IR and XPS, showing that the PVC samples were successfully modified. Energy Dispersive X-ray spectroscopy showed the spatial distribution of the elements Si and S, indicating that the coatings were homogeneous. The resulting PVC samples showed high antimicrobial activity against Gram-positive and Gram-negative bacteria. Furthermore, the biofilm formation was negligible in comparison with the untreated material. The coating elusion assay indicated that its antimicrobial ability was achieved via direct contact rather than a controlled release mechanism.Fil: Villanueva, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: González, Joaquín Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Rodríguez Castellón, E.. Universidad de Málaga; EspañaFil: Teves, S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaElsevier Science2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38920Villanueva, María Emilia; González, Joaquín Antonio; Rodríguez Castellón, E.; Teves, S.; Copello, Guillermo Javier; Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer; Elsevier Science; Materials Science and Engineering: C; 67; 10-2016; 214-2200928-4931CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2016.05.052info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493116304775info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:30:02Zoai:ri.conicet.gov.ar:11336/38920instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:30:03.169CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
title Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
spellingShingle Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
Villanueva, María Emilia
Antimicrobial Coating
Non-Leaching Coating
Poly Hexamethylenediamine Guanidine Hydrochloride
Pvc
title_short Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
title_full Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
title_fullStr Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
title_full_unstemmed Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
title_sort Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer
dc.creator.none.fl_str_mv Villanueva, María Emilia
González, Joaquín Antonio
Rodríguez Castellón, E.
Teves, S.
Copello, Guillermo Javier
author Villanueva, María Emilia
author_facet Villanueva, María Emilia
González, Joaquín Antonio
Rodríguez Castellón, E.
Teves, S.
Copello, Guillermo Javier
author_role author
author2 González, Joaquín Antonio
Rodríguez Castellón, E.
Teves, S.
Copello, Guillermo Javier
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antimicrobial Coating
Non-Leaching Coating
Poly Hexamethylenediamine Guanidine Hydrochloride
Pvc
topic Antimicrobial Coating
Non-Leaching Coating
Poly Hexamethylenediamine Guanidine Hydrochloride
Pvc
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Antimicrobial polyvinyl chloride (PVC) plastic was obtained by covalent bonding of poly hexamethylenediamine guanidine hydrochloride (PHMG), a guanidine based antimicrobial polymer. This was achieved by grafting mercaptopropyltrimethoxysilane onto PVC, followed by aminopropyltriethoxysilane. Glutaraldehyde is a bifunctional crosslinker that was bonded to the free amine groups found in the treated PVC on one side and PHMG on the other. The treated PVC samples were characterized by FT-IR and XPS, showing that the PVC samples were successfully modified. Energy Dispersive X-ray spectroscopy showed the spatial distribution of the elements Si and S, indicating that the coatings were homogeneous. The resulting PVC samples showed high antimicrobial activity against Gram-positive and Gram-negative bacteria. Furthermore, the biofilm formation was negligible in comparison with the untreated material. The coating elusion assay indicated that its antimicrobial ability was achieved via direct contact rather than a controlled release mechanism.
Fil: Villanueva, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: González, Joaquín Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Rodríguez Castellón, E.. Universidad de Málaga; España
Fil: Teves, S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description Antimicrobial polyvinyl chloride (PVC) plastic was obtained by covalent bonding of poly hexamethylenediamine guanidine hydrochloride (PHMG), a guanidine based antimicrobial polymer. This was achieved by grafting mercaptopropyltrimethoxysilane onto PVC, followed by aminopropyltriethoxysilane. Glutaraldehyde is a bifunctional crosslinker that was bonded to the free amine groups found in the treated PVC on one side and PHMG on the other. The treated PVC samples were characterized by FT-IR and XPS, showing that the PVC samples were successfully modified. Energy Dispersive X-ray spectroscopy showed the spatial distribution of the elements Si and S, indicating that the coatings were homogeneous. The resulting PVC samples showed high antimicrobial activity against Gram-positive and Gram-negative bacteria. Furthermore, the biofilm formation was negligible in comparison with the untreated material. The coating elusion assay indicated that its antimicrobial ability was achieved via direct contact rather than a controlled release mechanism.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38920
Villanueva, María Emilia; González, Joaquín Antonio; Rodríguez Castellón, E.; Teves, S.; Copello, Guillermo Javier; Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer; Elsevier Science; Materials Science and Engineering: C; 67; 10-2016; 214-220
0928-4931
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38920
identifier_str_mv Villanueva, María Emilia; González, Joaquín Antonio; Rodríguez Castellón, E.; Teves, S.; Copello, Guillermo Javier; Antimicrobial surface functionalization of PVC by a guanidine based antimicrobial polymer; Elsevier Science; Materials Science and Engineering: C; 67; 10-2016; 214-220
0928-4931
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2016.05.052
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493116304775
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082775020470272
score 13.22299

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