Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’

Autores
Alomar, María Lis; Gonzalez, Maria Micaela; Erra Balsells, Rosa; Cabrerizo, Franco Martín
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present manuscript is a comment on the article entitled “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach” by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA.
Fil: Alomar, María Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Fil: Gonzalez, Maria Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Fil: Erra Balsells, Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Cabrerizo, Franco Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Materia
Fotosensitizers
Dna
Harmalol
Carbolines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8156
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’Alomar, María LisGonzalez, Maria MicaelaErra Balsells, RosaCabrerizo, Franco MartínFotosensitizersDnaHarmalolCarbolineshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present manuscript is a comment on the article entitled “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach” by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA.Fil: Alomar, María Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); ArgentinaFil: Gonzalez, Maria Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); ArgentinaFil: Erra Balsells, Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Cabrerizo, Franco Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); ArgentinaElsevier2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8156Alomar, María Lis; Gonzalez, Maria Micaela; Erra Balsells, Rosa; Cabrerizo, Franco Martín; Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’; Elsevier; Journal Of Photochemistry And Photobiology B: Biology; 136; 1-2014; 26-281011-1344enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1011134414001250info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotobiol.2014.04.017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:09:36Zoai:ri.conicet.gov.ar:11336/8156instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:09:36.639CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
title Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
spellingShingle Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
Alomar, María Lis
Fotosensitizers
Dna
Harmalol
Carbolines
title_short Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
title_full Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
title_fullStr Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
title_full_unstemmed Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
title_sort Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’
dc.creator.none.fl_str_mv Alomar, María Lis
Gonzalez, Maria Micaela
Erra Balsells, Rosa
Cabrerizo, Franco Martín
author Alomar, María Lis
author_facet Alomar, María Lis
Gonzalez, Maria Micaela
Erra Balsells, Rosa
Cabrerizo, Franco Martín
author_role author
author2 Gonzalez, Maria Micaela
Erra Balsells, Rosa
Cabrerizo, Franco Martín
author2_role author
author
author
dc.subject.none.fl_str_mv Fotosensitizers
Dna
Harmalol
Carbolines
topic Fotosensitizers
Dna
Harmalol
Carbolines
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The present manuscript is a comment on the article entitled “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach” by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA.
Fil: Alomar, María Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Fil: Gonzalez, Maria Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Fil: Erra Balsells, Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Cabrerizo, Franco Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
description The present manuscript is a comment on the article entitled “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach” by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8156
Alomar, María Lis; Gonzalez, Maria Micaela; Erra Balsells, Rosa; Cabrerizo, Franco Martín; Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’; Elsevier; Journal Of Photochemistry And Photobiology B: Biology; 136; 1-2014; 26-28
1011-1344
url http://hdl.handle.net/11336/8156
identifier_str_mv Alomar, María Lis; Gonzalez, Maria Micaela; Erra Balsells, Rosa; Cabrerizo, Franco Martín; Comment on ‘‘Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach’’; Elsevier; Journal Of Photochemistry And Photobiology B: Biology; 136; 1-2014; 26-28
1011-1344
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1011134414001250
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotobiol.2014.04.017
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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