Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects
- Autores
- Chiarandini Fiore, Jessica Paola; Fanelli, Silvia Laura; de Ferreyra, Elida C.; Castro, Jose Alberto
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cisplatin (CisPt) is an effective chemotherapeutic agent against several human cancers, but it produces important nephrotoxicity, leukopenia, and mortality. In this work, we report initial results on the potential ability of diallyl disulfide (DADS) to block these toxicities without compromising chemotherapy. Male Sprague Dawley rats were used (control, DADS, CisPt, and CisPt/DADS). CisPt was administered sc as a single dose (10.5 mg/kg) in saline. DADS was given daily intragastrically in olive oil (292.5 mg/kg) 1 h before CisPt administration the first day and 146.25 mg/kg during the next 3 days. The animals were sacrificed at the fifth day after CisPt administration. DADS significantly decreased CisPt-induced nephrotoxicity as evaluated by histology and by seric urea (CisPt: 11.05 ± 3.59; CisPt/DADS: 6.53 ± 1.74) and creatinine (CisPt: 24.74 ± 3.03; CisPt/DADS: 14.83 ± 2.07). DADS also decreased leukopenia (CisPt: 13.5% and CisPt/DADS: 43.4% respect the control), and mortality (CisPt: 50%; CisPt/DADS: 29%). DADS showed ability to interact with reactive oxygen species (H2O2, hydroperoxides, OH•) and with iron. DADS treatment does not change Platinum levels in kidney (CisPt: 15.2 ± 5.1; CisPt/DADS: 13.9 ± 4.5). Because DADS is known to inhibit cellular replication and to promote apoptosis of tumor cells, results suggest that DADS merit to be tested as a potential coadjuvant of CisPt chemotherapy in tumor-bearing animals.
Fil: Chiarandini Fiore, Jessica Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
Fil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
Fil: de Ferreyra, Elida C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina - Materia
-
Diallyl Disulfide
Cisplatin
Nephrotoxicity - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/25566
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spelling |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effectsChiarandini Fiore, Jessica PaolaFanelli, Silvia Laurade Ferreyra, Elida C.Castro, Jose AlbertoDiallyl DisulfideCisplatinNephrotoxicityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cisplatin (CisPt) is an effective chemotherapeutic agent against several human cancers, but it produces important nephrotoxicity, leukopenia, and mortality. In this work, we report initial results on the potential ability of diallyl disulfide (DADS) to block these toxicities without compromising chemotherapy. Male Sprague Dawley rats were used (control, DADS, CisPt, and CisPt/DADS). CisPt was administered sc as a single dose (10.5 mg/kg) in saline. DADS was given daily intragastrically in olive oil (292.5 mg/kg) 1 h before CisPt administration the first day and 146.25 mg/kg during the next 3 days. The animals were sacrificed at the fifth day after CisPt administration. DADS significantly decreased CisPt-induced nephrotoxicity as evaluated by histology and by seric urea (CisPt: 11.05 ± 3.59; CisPt/DADS: 6.53 ± 1.74) and creatinine (CisPt: 24.74 ± 3.03; CisPt/DADS: 14.83 ± 2.07). DADS also decreased leukopenia (CisPt: 13.5% and CisPt/DADS: 43.4% respect the control), and mortality (CisPt: 50%; CisPt/DADS: 29%). DADS showed ability to interact with reactive oxygen species (H2O2, hydroperoxides, OH•) and with iron. DADS treatment does not change Platinum levels in kidney (CisPt: 15.2 ± 5.1; CisPt/DADS: 13.9 ± 4.5). Because DADS is known to inhibit cellular replication and to promote apoptosis of tumor cells, results suggest that DADS merit to be tested as a potential coadjuvant of CisPt chemotherapy in tumor-bearing animals.Fil: Chiarandini Fiore, Jessica Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); ArgentinaFil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); ArgentinaFil: de Ferreyra, Elida C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); ArgentinaFil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); ArgentinaTaylor & Francis2008-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25566Chiarandini Fiore, Jessica Paola; Fanelli, Silvia Laura; de Ferreyra, Elida C.; Castro, Jose Alberto; Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects; Taylor & Francis; Nutrition And Cancer; 60; 6; 11-2008; 784-7910163-5581CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/01635580802100869info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/01635580802100869info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:05Zoai:ri.conicet.gov.ar:11336/25566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:05.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
title |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
spellingShingle |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects Chiarandini Fiore, Jessica Paola Diallyl Disulfide Cisplatin Nephrotoxicity |
title_short |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
title_full |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
title_fullStr |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
title_full_unstemmed |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
title_sort |
Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects |
dc.creator.none.fl_str_mv |
Chiarandini Fiore, Jessica Paola Fanelli, Silvia Laura de Ferreyra, Elida C. Castro, Jose Alberto |
author |
Chiarandini Fiore, Jessica Paola |
author_facet |
Chiarandini Fiore, Jessica Paola Fanelli, Silvia Laura de Ferreyra, Elida C. Castro, Jose Alberto |
author_role |
author |
author2 |
Fanelli, Silvia Laura de Ferreyra, Elida C. Castro, Jose Alberto |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Diallyl Disulfide Cisplatin Nephrotoxicity |
topic |
Diallyl Disulfide Cisplatin Nephrotoxicity |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Cisplatin (CisPt) is an effective chemotherapeutic agent against several human cancers, but it produces important nephrotoxicity, leukopenia, and mortality. In this work, we report initial results on the potential ability of diallyl disulfide (DADS) to block these toxicities without compromising chemotherapy. Male Sprague Dawley rats were used (control, DADS, CisPt, and CisPt/DADS). CisPt was administered sc as a single dose (10.5 mg/kg) in saline. DADS was given daily intragastrically in olive oil (292.5 mg/kg) 1 h before CisPt administration the first day and 146.25 mg/kg during the next 3 days. The animals were sacrificed at the fifth day after CisPt administration. DADS significantly decreased CisPt-induced nephrotoxicity as evaluated by histology and by seric urea (CisPt: 11.05 ± 3.59; CisPt/DADS: 6.53 ± 1.74) and creatinine (CisPt: 24.74 ± 3.03; CisPt/DADS: 14.83 ± 2.07). DADS also decreased leukopenia (CisPt: 13.5% and CisPt/DADS: 43.4% respect the control), and mortality (CisPt: 50%; CisPt/DADS: 29%). DADS showed ability to interact with reactive oxygen species (H2O2, hydroperoxides, OH•) and with iron. DADS treatment does not change Platinum levels in kidney (CisPt: 15.2 ± 5.1; CisPt/DADS: 13.9 ± 4.5). Because DADS is known to inhibit cellular replication and to promote apoptosis of tumor cells, results suggest that DADS merit to be tested as a potential coadjuvant of CisPt chemotherapy in tumor-bearing animals. Fil: Chiarandini Fiore, Jessica Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina Fil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina Fil: de Ferreyra, Elida C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Gp.citefa - Centro de Investigaciones Toxicológicas (i); Argentina |
description |
Cisplatin (CisPt) is an effective chemotherapeutic agent against several human cancers, but it produces important nephrotoxicity, leukopenia, and mortality. In this work, we report initial results on the potential ability of diallyl disulfide (DADS) to block these toxicities without compromising chemotherapy. Male Sprague Dawley rats were used (control, DADS, CisPt, and CisPt/DADS). CisPt was administered sc as a single dose (10.5 mg/kg) in saline. DADS was given daily intragastrically in olive oil (292.5 mg/kg) 1 h before CisPt administration the first day and 146.25 mg/kg during the next 3 days. The animals were sacrificed at the fifth day after CisPt administration. DADS significantly decreased CisPt-induced nephrotoxicity as evaluated by histology and by seric urea (CisPt: 11.05 ± 3.59; CisPt/DADS: 6.53 ± 1.74) and creatinine (CisPt: 24.74 ± 3.03; CisPt/DADS: 14.83 ± 2.07). DADS also decreased leukopenia (CisPt: 13.5% and CisPt/DADS: 43.4% respect the control), and mortality (CisPt: 50%; CisPt/DADS: 29%). DADS showed ability to interact with reactive oxygen species (H2O2, hydroperoxides, OH•) and with iron. DADS treatment does not change Platinum levels in kidney (CisPt: 15.2 ± 5.1; CisPt/DADS: 13.9 ± 4.5). Because DADS is known to inhibit cellular replication and to promote apoptosis of tumor cells, results suggest that DADS merit to be tested as a potential coadjuvant of CisPt chemotherapy in tumor-bearing animals. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/25566 Chiarandini Fiore, Jessica Paola; Fanelli, Silvia Laura; de Ferreyra, Elida C.; Castro, Jose Alberto; Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects; Taylor & Francis; Nutrition And Cancer; 60; 6; 11-2008; 784-791 0163-5581 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/25566 |
identifier_str_mv |
Chiarandini Fiore, Jessica Paola; Fanelli, Silvia Laura; de Ferreyra, Elida C.; Castro, Jose Alberto; Diallyl Disulfide prevention of Cis-diammine Dichloroplatinum–induced Nephrotoxicity and Leukopenia in rats: potential adjuvant effects; Taylor & Francis; Nutrition And Cancer; 60; 6; 11-2008; 784-791 0163-5581 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1080/01635580802100869 info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/01635580802100869 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842270068732329984 |
score |
13.13397 |