Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling

Autores
Carpentieri, Agata Rita; Oliva, Clara; Diez Noguera, Antoni; Cambras, Trinitat
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Early lighting conditions have been described to produce long-term effects on circadian behavior, which may also influence the response to agents acting on the circadian system. It has been suggested that melatonin (MEL) may act on the circadian pacemaker and as a scavenger of reactive oxygen and nitrogen species. Here, we studied the oxidative and behavioral changes caused by prolonged exposure to constant light (LL) in groups of rats that differed in MEL administration and in lighting conditions during suckling. The rats were exposed to either a light–dark cycle (LD) or LL. At 40 days old, rats were treated for 2 weeks with a daily subcutaneous injection of MEL (10 mg/kg body weight) or a vehicle at activity onset. Blood samples were taken before and after treatment, to determine catalase (CAT) activity and nitrite level in plasma. As expected, LL-reared rats showed a more stable motor activity circadian rhythm than LD rats. MEL treatment produced more reactivity in LD- than in LL rats, and was also able to alter the phase of the rhythm in LD rats. There were no significant differences in nitrite levels or CAT activity between the groups, although both variables increased with time. Finally, we also tested depressive signs by means of sucrose consumption, and anhedonia was found in LD males treated with MEL. The results suggest that the lighting conditions in early infancy are important for the long-term functionality of the circadian system, including rhythm manifestation, responses to MEL and mood alterations.
Fil: Carpentieri, Agata Rita. Universidad de Barcelona. Facultad de Farmacia; España. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Oliva, Clara. Universidad de Barcelona. Facultad de Farmacia; España
Fil: Diez Noguera, Antoni. Universidad de Barcelona. Facultad de Farmacia; España
Fil: Cambras, Trinitat. Universidad de Barcelona. Facultad de Farmacia; España
Materia
Melatonin
Circadian Rhythms
Synchronization
Constant Light
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11358
Acceder
id CONICETDig_7eaed694fc50b09965c03ab43a525921
oai_identifier_str oai:ri.conicet.gov.ar:11336/11358
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during sucklingCarpentieri, Agata RitaOliva, ClaraDiez Noguera, AntoniCambras, TrinitatMelatoninCircadian RhythmsSynchronizationConstant Lighthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Early lighting conditions have been described to produce long-term effects on circadian behavior, which may also influence the response to agents acting on the circadian system. It has been suggested that melatonin (MEL) may act on the circadian pacemaker and as a scavenger of reactive oxygen and nitrogen species. Here, we studied the oxidative and behavioral changes caused by prolonged exposure to constant light (LL) in groups of rats that differed in MEL administration and in lighting conditions during suckling. The rats were exposed to either a light–dark cycle (LD) or LL. At 40 days old, rats were treated for 2 weeks with a daily subcutaneous injection of MEL (10 mg/kg body weight) or a vehicle at activity onset. Blood samples were taken before and after treatment, to determine catalase (CAT) activity and nitrite level in plasma. As expected, LL-reared rats showed a more stable motor activity circadian rhythm than LD rats. MEL treatment produced more reactivity in LD- than in LL rats, and was also able to alter the phase of the rhythm in LD rats. There were no significant differences in nitrite levels or CAT activity between the groups, although both variables increased with time. Finally, we also tested depressive signs by means of sucrose consumption, and anhedonia was found in LD males treated with MEL. The results suggest that the lighting conditions in early infancy are important for the long-term functionality of the circadian system, including rhythm manifestation, responses to MEL and mood alterations.Fil: Carpentieri, Agata Rita. Universidad de Barcelona. Facultad de Farmacia; España. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Oliva, Clara. Universidad de Barcelona. Facultad de Farmacia; EspañaFil: Diez Noguera, Antoni. Universidad de Barcelona. Facultad de Farmacia; EspañaFil: Cambras, Trinitat. Universidad de Barcelona. Facultad de Farmacia; EspañaTaylor & Francis2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11358Carpentieri, Agata Rita; Oliva, Clara; Diez Noguera, Antoni; Cambras, Trinitat; Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling; Taylor & Francis; Chronobiology International; 32; 7; 7-2015; 994-10040742-05281525-6073enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:43Zoai:ri.conicet.gov.ar:11336/11358instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:44.115CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
title Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
spellingShingle Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
Carpentieri, Agata Rita
Melatonin
Circadian Rhythms
Synchronization
Constant Light
title_short Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
title_full Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
title_fullStr Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
title_full_unstemmed Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
title_sort Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling
dc.creator.none.fl_str_mv Carpentieri, Agata Rita
Oliva, Clara
Diez Noguera, Antoni
Cambras, Trinitat
author Carpentieri, Agata Rita
author_facet Carpentieri, Agata Rita
Oliva, Clara
Diez Noguera, Antoni
Cambras, Trinitat
author_role author
author2 Oliva, Clara
Diez Noguera, Antoni
Cambras, Trinitat
author2_role author
author
author
dc.subject.none.fl_str_mv Melatonin
Circadian Rhythms
Synchronization
Constant Light
topic Melatonin
Circadian Rhythms
Synchronization
Constant Light
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Early lighting conditions have been described to produce long-term effects on circadian behavior, which may also influence the response to agents acting on the circadian system. It has been suggested that melatonin (MEL) may act on the circadian pacemaker and as a scavenger of reactive oxygen and nitrogen species. Here, we studied the oxidative and behavioral changes caused by prolonged exposure to constant light (LL) in groups of rats that differed in MEL administration and in lighting conditions during suckling. The rats were exposed to either a light–dark cycle (LD) or LL. At 40 days old, rats were treated for 2 weeks with a daily subcutaneous injection of MEL (10 mg/kg body weight) or a vehicle at activity onset. Blood samples were taken before and after treatment, to determine catalase (CAT) activity and nitrite level in plasma. As expected, LL-reared rats showed a more stable motor activity circadian rhythm than LD rats. MEL treatment produced more reactivity in LD- than in LL rats, and was also able to alter the phase of the rhythm in LD rats. There were no significant differences in nitrite levels or CAT activity between the groups, although both variables increased with time. Finally, we also tested depressive signs by means of sucrose consumption, and anhedonia was found in LD males treated with MEL. The results suggest that the lighting conditions in early infancy are important for the long-term functionality of the circadian system, including rhythm manifestation, responses to MEL and mood alterations.
Fil: Carpentieri, Agata Rita. Universidad de Barcelona. Facultad de Farmacia; España. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Oliva, Clara. Universidad de Barcelona. Facultad de Farmacia; España
Fil: Diez Noguera, Antoni. Universidad de Barcelona. Facultad de Farmacia; España
Fil: Cambras, Trinitat. Universidad de Barcelona. Facultad de Farmacia; España
description Early lighting conditions have been described to produce long-term effects on circadian behavior, which may also influence the response to agents acting on the circadian system. It has been suggested that melatonin (MEL) may act on the circadian pacemaker and as a scavenger of reactive oxygen and nitrogen species. Here, we studied the oxidative and behavioral changes caused by prolonged exposure to constant light (LL) in groups of rats that differed in MEL administration and in lighting conditions during suckling. The rats were exposed to either a light–dark cycle (LD) or LL. At 40 days old, rats were treated for 2 weeks with a daily subcutaneous injection of MEL (10 mg/kg body weight) or a vehicle at activity onset. Blood samples were taken before and after treatment, to determine catalase (CAT) activity and nitrite level in plasma. As expected, LL-reared rats showed a more stable motor activity circadian rhythm than LD rats. MEL treatment produced more reactivity in LD- than in LL rats, and was also able to alter the phase of the rhythm in LD rats. There were no significant differences in nitrite levels or CAT activity between the groups, although both variables increased with time. Finally, we also tested depressive signs by means of sucrose consumption, and anhedonia was found in LD males treated with MEL. The results suggest that the lighting conditions in early infancy are important for the long-term functionality of the circadian system, including rhythm manifestation, responses to MEL and mood alterations.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11358
Carpentieri, Agata Rita; Oliva, Clara; Diez Noguera, Antoni; Cambras, Trinitat; Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling; Taylor & Francis; Chronobiology International; 32; 7; 7-2015; 994-1004
0742-0528
1525-6073
url http://hdl.handle.net/11336/11358
identifier_str_mv Carpentieri, Agata Rita; Oliva, Clara; Diez Noguera, Antoni; Cambras, Trinitat; Melatonin administration modifies circadian motor activity under constant light depending on the lighting conditions during suckling; Taylor & Francis; Chronobiology International; 32; 7; 7-2015; 994-1004
0742-0528
1525-6073
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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