Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

Autores
Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos Alberto; Alche, Laura Edith; Leonti, Marco; Vargiu, Simona; Bifulco, Ersilia; Menkissoglu Spiroudi, Urania; Caboni, Pierluigi
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β- acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
Fil: Ntalli, Nikoletta G.. Aristotle University of Thessaloniki; Grecia
Fil: Cottiglia, Filippo. Università degli studi di Cagliari; Italia
Fil: Bueno, Carlos Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alche, Laura Edith. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leonti, Marco. Università degli studi di Cagliari; Italia
Fil: Vargiu, Simona. Università degli Studi di Cagliari; Italia
Fil: Bifulco, Ersilia. Università degli Studi di Cagliari; Italia
Fil: Menkissoglu Spiroudi, Urania. Aristotle University of Thessaloniki; Grecia
Fil: Caboni, Pierluigi. Università degli Studi di Cagliari; Italia
Materia
METHYL KULONATE
3-ALFA-TIGLOYLMELIANOL
MELIANONE
21-BETA-ACETOXY-MELIANONE
CYTOTOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16577
Acceder
id CONICETDig_7d4412ce712c545f8cf65b3542003886
oai_identifier_str oai:ri.conicet.gov.ar:11336/16577
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytotoxic Tirucallane Triterpenoids from Melia azedarach FruitsNtalli, Nikoletta G.Cottiglia, FilippoBueno, Carlos AlbertoAlche, Laura EdithLeonti, MarcoVargiu, SimonaBifulco, ErsiliaMenkissoglu Spiroudi, UraniaCaboni, PierluigiMETHYL KULONATE3-ALFA-TIGLOYLMELIANOLMELIANONE21-BETA-ACETOXY-MELIANONECYTOTOXICITYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β- acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.Fil: Ntalli, Nikoletta G.. Aristotle University of Thessaloniki; GreciaFil: Cottiglia, Filippo. Università degli studi di Cagliari; ItaliaFil: Bueno, Carlos Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alche, Laura Edith. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Leonti, Marco. Università degli studi di Cagliari; ItaliaFil: Vargiu, Simona. Università degli Studi di Cagliari; ItaliaFil: Bifulco, Ersilia. Università degli Studi di Cagliari; ItaliaFil: Menkissoglu Spiroudi, Urania. Aristotle University of Thessaloniki; GreciaFil: Caboni, Pierluigi. Università degli Studi di Cagliari; ItaliaMolecular Diversity Preservation International2010-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16577Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos Alberto; Alche, Laura Edith; Leonti, Marco; et al.; Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits ; Molecular Diversity Preservation International; Molecules; 15; 9; 8-2010; 5866-58771420-3049enginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules15095866info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/15/9/5866info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-06-10T09:48:19Zoai:ri.conicet.gov.ar:11336/16577instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-06-10 09:48:20.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
spellingShingle Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
Ntalli, Nikoletta G.
METHYL KULONATE
3-ALFA-TIGLOYLMELIANOL
MELIANONE
21-BETA-ACETOXY-MELIANONE
CYTOTOXICITY
title_short Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_full Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_fullStr Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_full_unstemmed Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_sort Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
dc.creator.none.fl_str_mv Ntalli, Nikoletta G.
Cottiglia, Filippo
Bueno, Carlos Alberto
Alche, Laura Edith
Leonti, Marco
Vargiu, Simona
Bifulco, Ersilia
Menkissoglu Spiroudi, Urania
Caboni, Pierluigi
author Ntalli, Nikoletta G.
author_facet Ntalli, Nikoletta G.
Cottiglia, Filippo
Bueno, Carlos Alberto
Alche, Laura Edith
Leonti, Marco
Vargiu, Simona
Bifulco, Ersilia
Menkissoglu Spiroudi, Urania
Caboni, Pierluigi
author_role author
author2 Cottiglia, Filippo
Bueno, Carlos Alberto
Alche, Laura Edith
Leonti, Marco
Vargiu, Simona
Bifulco, Ersilia
Menkissoglu Spiroudi, Urania
Caboni, Pierluigi
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv METHYL KULONATE
3-ALFA-TIGLOYLMELIANOL
MELIANONE
21-BETA-ACETOXY-MELIANONE
CYTOTOXICITY
topic METHYL KULONATE
3-ALFA-TIGLOYLMELIANOL
MELIANONE
21-BETA-ACETOXY-MELIANONE
CYTOTOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β- acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
Fil: Ntalli, Nikoletta G.. Aristotle University of Thessaloniki; Grecia
Fil: Cottiglia, Filippo. Università degli studi di Cagliari; Italia
Fil: Bueno, Carlos Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alche, Laura Edith. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leonti, Marco. Università degli studi di Cagliari; Italia
Fil: Vargiu, Simona. Università degli Studi di Cagliari; Italia
Fil: Bifulco, Ersilia. Università degli Studi di Cagliari; Italia
Fil: Menkissoglu Spiroudi, Urania. Aristotle University of Thessaloniki; Grecia
Fil: Caboni, Pierluigi. Università degli Studi di Cagliari; Italia
description The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β- acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
publishDate 2010
dc.date.none.fl_str_mv 2010-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16577
Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos Alberto; Alche, Laura Edith; Leonti, Marco; et al.; Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits ; Molecular Diversity Preservation International; Molecules; 15; 9; 8-2010; 5866-5877
1420-3049
url http://hdl.handle.net/11336/16577
identifier_str_mv Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos Alberto; Alche, Laura Edith; Leonti, Marco; et al.; Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits ; Molecular Diversity Preservation International; Molecules; 15; 9; 8-2010; 5866-5877
1420-3049
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules15095866
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/15/9/5866
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1867629292549046272
score 12.98848

Publicaciones similares