The structure and evolution of cisregulatory regions: The shavenbaby story
- Autores
- Stern, David L.; Frankel, Nicolás
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.
Fil: Stern, David L.. Howard Hughes Medical Institute; Estados Unidos
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina - Materia
-
CIS-REGULATORY EVOLUTION
CIS-REGULATORY STRUCTURE
EVOLUTION OF ENHANCER FUNCTION
MORPHOLOGICAL CHANGE
SHAVENBABY GENE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/86055
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The structure and evolution of cisregulatory regions: The shavenbaby storyStern, David L.Frankel, NicolásCIS-REGULATORY EVOLUTIONCIS-REGULATORY STRUCTUREEVOLUTION OF ENHANCER FUNCTIONMORPHOLOGICAL CHANGESHAVENBABY GENEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.Fil: Stern, David L.. Howard Hughes Medical Institute; Estados UnidosFil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaThe Royal Society2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86055Stern, David L.; Frankel, Nicolás; The structure and evolution of cisregulatory regions: The shavenbaby story; The Royal Society; Philosophical Transactions of the Royal Society B: Biological Sciences; 368; 1632; 12-2013; 1-110962-8436CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1098/rstb.2013.0028info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/10.1098/rstb.2013.0028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:29Zoai:ri.conicet.gov.ar:11336/86055instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:29.571CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The structure and evolution of cisregulatory regions: The shavenbaby story |
title |
The structure and evolution of cisregulatory regions: The shavenbaby story |
spellingShingle |
The structure and evolution of cisregulatory regions: The shavenbaby story Stern, David L. CIS-REGULATORY EVOLUTION CIS-REGULATORY STRUCTURE EVOLUTION OF ENHANCER FUNCTION MORPHOLOGICAL CHANGE SHAVENBABY GENE |
title_short |
The structure and evolution of cisregulatory regions: The shavenbaby story |
title_full |
The structure and evolution of cisregulatory regions: The shavenbaby story |
title_fullStr |
The structure and evolution of cisregulatory regions: The shavenbaby story |
title_full_unstemmed |
The structure and evolution of cisregulatory regions: The shavenbaby story |
title_sort |
The structure and evolution of cisregulatory regions: The shavenbaby story |
dc.creator.none.fl_str_mv |
Stern, David L. Frankel, Nicolás |
author |
Stern, David L. |
author_facet |
Stern, David L. Frankel, Nicolás |
author_role |
author |
author2 |
Frankel, Nicolás |
author2_role |
author |
dc.subject.none.fl_str_mv |
CIS-REGULATORY EVOLUTION CIS-REGULATORY STRUCTURE EVOLUTION OF ENHANCER FUNCTION MORPHOLOGICAL CHANGE SHAVENBABY GENE |
topic |
CIS-REGULATORY EVOLUTION CIS-REGULATORY STRUCTURE EVOLUTION OF ENHANCER FUNCTION MORPHOLOGICAL CHANGE SHAVENBABY GENE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes. Fil: Stern, David L.. Howard Hughes Medical Institute; Estados Unidos Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina |
description |
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/86055 Stern, David L.; Frankel, Nicolás; The structure and evolution of cisregulatory regions: The shavenbaby story; The Royal Society; Philosophical Transactions of the Royal Society B: Biological Sciences; 368; 1632; 12-2013; 1-11 0962-8436 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/86055 |
identifier_str_mv |
Stern, David L.; Frankel, Nicolás; The structure and evolution of cisregulatory regions: The shavenbaby story; The Royal Society; Philosophical Transactions of the Royal Society B: Biological Sciences; 368; 1632; 12-2013; 1-11 0962-8436 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1098/rstb.2013.0028 info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/10.1098/rstb.2013.0028 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
The Royal Society |
publisher.none.fl_str_mv |
The Royal Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |