The structure and evolution of cisregulatory regions: The shavenbaby story

Autores
Stern, David L.; Frankel, Nicolás
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.
Fil: Stern, David L.. Howard Hughes Medical Institute; Estados Unidos
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Materia
CIS-REGULATORY EVOLUTION
CIS-REGULATORY STRUCTURE
EVOLUTION OF ENHANCER FUNCTION
MORPHOLOGICAL CHANGE
SHAVENBABY GENE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86055
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/86055
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network_name_str CONICET Digital (CONICET)
spelling The structure and evolution of cisregulatory regions: The shavenbaby storyStern, David L.Frankel, NicolásCIS-REGULATORY EVOLUTIONCIS-REGULATORY STRUCTUREEVOLUTION OF ENHANCER FUNCTIONMORPHOLOGICAL CHANGESHAVENBABY GENEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.Fil: Stern, David L.. Howard Hughes Medical Institute; Estados UnidosFil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaThe Royal Society2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86055Stern, David L.; Frankel, Nicolás; The structure and evolution of cisregulatory regions: The shavenbaby story; The Royal Society; Philosophical Transactions of the Royal Society B: Biological Sciences; 368; 1632; 12-2013; 1-110962-8436CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1098/rstb.2013.0028info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/10.1098/rstb.2013.0028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:39:24Zoai:ri.conicet.gov.ar:11336/86055instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:39:25.093CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The structure and evolution of cisregulatory regions: The shavenbaby story
title The structure and evolution of cisregulatory regions: The shavenbaby story
spellingShingle The structure and evolution of cisregulatory regions: The shavenbaby story
Stern, David L.
CIS-REGULATORY EVOLUTION
CIS-REGULATORY STRUCTURE
EVOLUTION OF ENHANCER FUNCTION
MORPHOLOGICAL CHANGE
SHAVENBABY GENE
title_short The structure and evolution of cisregulatory regions: The shavenbaby story
title_full The structure and evolution of cisregulatory regions: The shavenbaby story
title_fullStr The structure and evolution of cisregulatory regions: The shavenbaby story
title_full_unstemmed The structure and evolution of cisregulatory regions: The shavenbaby story
title_sort The structure and evolution of cisregulatory regions: The shavenbaby story
dc.creator.none.fl_str_mv Stern, David L.
Frankel, Nicolás
author Stern, David L.
author_facet Stern, David L.
Frankel, Nicolás
author_role author
author2 Frankel, Nicolás
author2_role author
dc.subject.none.fl_str_mv CIS-REGULATORY EVOLUTION
CIS-REGULATORY STRUCTURE
EVOLUTION OF ENHANCER FUNCTION
MORPHOLOGICAL CHANGE
SHAVENBABY GENE
topic CIS-REGULATORY EVOLUTION
CIS-REGULATORY STRUCTURE
EVOLUTION OF ENHANCER FUNCTION
MORPHOLOGICAL CHANGE
SHAVENBABY GENE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.
Fil: Stern, David L.. Howard Hughes Medical Institute; Estados Unidos
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
description In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86055
Stern, David L.; Frankel, Nicolás; The structure and evolution of cisregulatory regions: The shavenbaby story; The Royal Society; Philosophical Transactions of the Royal Society B: Biological Sciences; 368; 1632; 12-2013; 1-11
0962-8436
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86055
identifier_str_mv Stern, David L.; Frankel, Nicolás; The structure and evolution of cisregulatory regions: The shavenbaby story; The Royal Society; Philosophical Transactions of the Royal Society B: Biological Sciences; 368; 1632; 12-2013; 1-11
0962-8436
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1098/rstb.2013.0028
info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/10.1098/rstb.2013.0028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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