Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)

Autores
Sir, Esteban Benjamin; Kuhnert, Eric; Surup, Frank; Hyde, Kevin D.; Stadler, Marc
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A specimen of the Hypoxylon rubiginosum complex featuring unusual bicoloured stromata was collected in northern Thailand and examined by means of classical morphological methodology, complemented by studies of its secondary metabolites using high performance liquid chromatography coupled with diode array and electrospray mass spectrometric detection (HPLC-DAD/MS), and molecular phylogenetic analysis of its ITS and partial beta-tubulin DNA sequences. In addition, the ultrastructure of its ascospores was examined by SEM. The chemotaxonomic studies revealed the presence of two putatively unknown, apparently specific azaphilone pigments in the stromata. These metabolites were consequently isolated to purity by preparative HPLC and identified by means of nuclear magnetic resonance spectroscopy and high resolution mass spectrometry as the novel natural products, (+)-6″-hydroxymitorubrinol acetate (1) and (+)-6″-hydroxymitorubrinol (3).
Fil: Sir, Esteban Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Fundación Miguel Lillo. Dirección de Botánica. Instituto de Micología; Argentina
Fil: Kuhnert, Eric. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; Alemania
Fil: Surup, Frank. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; Alemania
Fil: Hyde, Kevin D.. Mae Fah Luang University. Institute of Excellence in Fungal Research and School of Science; Tailandia
Fil: Stadler, Marc. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; Alemania
Materia
Azaphilones
Hypoxylon
Molecular Phylogeny
Secondary Metabolites
Taxonomy
Xylariales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/58071
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)Sir, Esteban BenjaminKuhnert, EricSurup, FrankHyde, Kevin D.Stadler, MarcAzaphilonesHypoxylonMolecular PhylogenySecondary MetabolitesTaxonomyXylarialeshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A specimen of the Hypoxylon rubiginosum complex featuring unusual bicoloured stromata was collected in northern Thailand and examined by means of classical morphological methodology, complemented by studies of its secondary metabolites using high performance liquid chromatography coupled with diode array and electrospray mass spectrometric detection (HPLC-DAD/MS), and molecular phylogenetic analysis of its ITS and partial beta-tubulin DNA sequences. In addition, the ultrastructure of its ascospores was examined by SEM. The chemotaxonomic studies revealed the presence of two putatively unknown, apparently specific azaphilone pigments in the stromata. These metabolites were consequently isolated to purity by preparative HPLC and identified by means of nuclear magnetic resonance spectroscopy and high resolution mass spectrometry as the novel natural products, (+)-6″-hydroxymitorubrinol acetate (1) and (+)-6″-hydroxymitorubrinol (3).Fil: Sir, Esteban Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Fundación Miguel Lillo. Dirección de Botánica. Instituto de Micología; ArgentinaFil: Kuhnert, Eric. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; AlemaniaFil: Surup, Frank. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; AlemaniaFil: Hyde, Kevin D.. Mae Fah Luang University. Institute of Excellence in Fungal Research and School of Science; TailandiaFil: Stadler, Marc. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; AlemaniaSpringer Heidelberg2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/58071Sir, Esteban Benjamin; Kuhnert, Eric; Surup, Frank; Hyde, Kevin D.; Stadler, Marc; Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales); Springer Heidelberg; Mycological Progress; 14; 5; 4-2015; 1-121617-416XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11557-015-1043-1info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11557-015-1043-1info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:28Zoai:ri.conicet.gov.ar:11336/58071instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:28.594CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
title Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
spellingShingle Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
Sir, Esteban Benjamin
Azaphilones
Hypoxylon
Molecular Phylogeny
Secondary Metabolites
Taxonomy
Xylariales
title_short Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
title_full Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
title_fullStr Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
title_full_unstemmed Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
title_sort Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
dc.creator.none.fl_str_mv Sir, Esteban Benjamin
Kuhnert, Eric
Surup, Frank
Hyde, Kevin D.
Stadler, Marc
author Sir, Esteban Benjamin
author_facet Sir, Esteban Benjamin
Kuhnert, Eric
Surup, Frank
Hyde, Kevin D.
Stadler, Marc
author_role author
author2 Kuhnert, Eric
Surup, Frank
Hyde, Kevin D.
Stadler, Marc
author2_role author
author
author
author
dc.subject.none.fl_str_mv Azaphilones
Hypoxylon
Molecular Phylogeny
Secondary Metabolites
Taxonomy
Xylariales
topic Azaphilones
Hypoxylon
Molecular Phylogeny
Secondary Metabolites
Taxonomy
Xylariales
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A specimen of the Hypoxylon rubiginosum complex featuring unusual bicoloured stromata was collected in northern Thailand and examined by means of classical morphological methodology, complemented by studies of its secondary metabolites using high performance liquid chromatography coupled with diode array and electrospray mass spectrometric detection (HPLC-DAD/MS), and molecular phylogenetic analysis of its ITS and partial beta-tubulin DNA sequences. In addition, the ultrastructure of its ascospores was examined by SEM. The chemotaxonomic studies revealed the presence of two putatively unknown, apparently specific azaphilone pigments in the stromata. These metabolites were consequently isolated to purity by preparative HPLC and identified by means of nuclear magnetic resonance spectroscopy and high resolution mass spectrometry as the novel natural products, (+)-6″-hydroxymitorubrinol acetate (1) and (+)-6″-hydroxymitorubrinol (3).
Fil: Sir, Esteban Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Fundación Miguel Lillo. Dirección de Botánica. Instituto de Micología; Argentina
Fil: Kuhnert, Eric. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; Alemania
Fil: Surup, Frank. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; Alemania
Fil: Hyde, Kevin D.. Mae Fah Luang University. Institute of Excellence in Fungal Research and School of Science; Tailandia
Fil: Stadler, Marc. Helmholtz-Zentrum für Infektionsforschung; Alemania. German Centre for Infection Research; Alemania
description A specimen of the Hypoxylon rubiginosum complex featuring unusual bicoloured stromata was collected in northern Thailand and examined by means of classical morphological methodology, complemented by studies of its secondary metabolites using high performance liquid chromatography coupled with diode array and electrospray mass spectrometric detection (HPLC-DAD/MS), and molecular phylogenetic analysis of its ITS and partial beta-tubulin DNA sequences. In addition, the ultrastructure of its ascospores was examined by SEM. The chemotaxonomic studies revealed the presence of two putatively unknown, apparently specific azaphilone pigments in the stromata. These metabolites were consequently isolated to purity by preparative HPLC and identified by means of nuclear magnetic resonance spectroscopy and high resolution mass spectrometry as the novel natural products, (+)-6″-hydroxymitorubrinol acetate (1) and (+)-6″-hydroxymitorubrinol (3).
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/58071
Sir, Esteban Benjamin; Kuhnert, Eric; Surup, Frank; Hyde, Kevin D.; Stadler, Marc; Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales); Springer Heidelberg; Mycological Progress; 14; 5; 4-2015; 1-12
1617-416X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/58071
identifier_str_mv Sir, Esteban Benjamin; Kuhnert, Eric; Surup, Frank; Hyde, Kevin D.; Stadler, Marc; Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales); Springer Heidelberg; Mycological Progress; 14; 5; 4-2015; 1-12
1617-416X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s11557-015-1043-1
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11557-015-1043-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Heidelberg
publisher.none.fl_str_mv Springer Heidelberg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613249025179648
score 13.069144

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