HPLC assay for meprednisone in tablets

Autores
Ceresole, Rita; Rosasco, María Ana; Segall, Adriana Ines
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A high performance liquid chromatographic (HPLC) method is presented for the determination of meprednisone in the presence of its degradation products using a reverse phase C18 column at ambient temperature with mobile phase consisting of acetonitrile:0.04M dibasic sodium phosphate, pH adjusted to 7.0 (45:65, v/v). The flow rate was 1.3mL/min. Quantitation was achieved with UV detection at 245nm based on peak area. The method was developed and validated for the determination of meprednisone in tablets. The proposed method was validated for selectivity, linearity, accuracy, and robustness. The method was found to be suitable for the quality control of meprednisone in tablets as well as the stability indicating studies.
Fil: Ceresole, Rita. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ASSAY
HPLC
MEPREDNISONE
STABILITY INDICATING METHOD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115006
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/115006
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling HPLC assay for meprednisone in tabletsCeresole, RitaRosasco, María AnaSegall, Adriana InesASSAYHPLCMEPREDNISONESTABILITY INDICATING METHODhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3A high performance liquid chromatographic (HPLC) method is presented for the determination of meprednisone in the presence of its degradation products using a reverse phase C18 column at ambient temperature with mobile phase consisting of acetonitrile:0.04M dibasic sodium phosphate, pH adjusted to 7.0 (45:65, v/v). The flow rate was 1.3mL/min. Quantitation was achieved with UV detection at 245nm based on peak area. The method was developed and validated for the determination of meprednisone in tablets. The proposed method was validated for selectivity, linearity, accuracy, and robustness. The method was found to be suitable for the quality control of meprednisone in tablets as well as the stability indicating studies.Fil: Ceresole, Rita. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; ArgentinaFil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; ArgentinaFil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaTaylor & Francis2009-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115006Ceresole, Rita; Rosasco, María Ana; Segall, Adriana Ines; HPLC assay for meprednisone in tablets; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 32; 19; 1-2009; 2795-28041082-6076CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10826070903288144info:eu-repo/semantics/altIdentifier/doi/10.1080/10826070903288144info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:54Zoai:ri.conicet.gov.ar:11336/115006instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:55.618CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv HPLC assay for meprednisone in tablets
title HPLC assay for meprednisone in tablets
spellingShingle HPLC assay for meprednisone in tablets
Ceresole, Rita
ASSAY
HPLC
MEPREDNISONE
STABILITY INDICATING METHOD
title_short HPLC assay for meprednisone in tablets
title_full HPLC assay for meprednisone in tablets
title_fullStr HPLC assay for meprednisone in tablets
title_full_unstemmed HPLC assay for meprednisone in tablets
title_sort HPLC assay for meprednisone in tablets
dc.creator.none.fl_str_mv Ceresole, Rita
Rosasco, María Ana
Segall, Adriana Ines
author Ceresole, Rita
author_facet Ceresole, Rita
Rosasco, María Ana
Segall, Adriana Ines
author_role author
author2 Rosasco, María Ana
Segall, Adriana Ines
author2_role author
author
dc.subject.none.fl_str_mv ASSAY
HPLC
MEPREDNISONE
STABILITY INDICATING METHOD
topic ASSAY
HPLC
MEPREDNISONE
STABILITY INDICATING METHOD
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A high performance liquid chromatographic (HPLC) method is presented for the determination of meprednisone in the presence of its degradation products using a reverse phase C18 column at ambient temperature with mobile phase consisting of acetonitrile:0.04M dibasic sodium phosphate, pH adjusted to 7.0 (45:65, v/v). The flow rate was 1.3mL/min. Quantitation was achieved with UV detection at 245nm based on peak area. The method was developed and validated for the determination of meprednisone in tablets. The proposed method was validated for selectivity, linearity, accuracy, and robustness. The method was found to be suitable for the quality control of meprednisone in tablets as well as the stability indicating studies.
Fil: Ceresole, Rita. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description A high performance liquid chromatographic (HPLC) method is presented for the determination of meprednisone in the presence of its degradation products using a reverse phase C18 column at ambient temperature with mobile phase consisting of acetonitrile:0.04M dibasic sodium phosphate, pH adjusted to 7.0 (45:65, v/v). The flow rate was 1.3mL/min. Quantitation was achieved with UV detection at 245nm based on peak area. The method was developed and validated for the determination of meprednisone in tablets. The proposed method was validated for selectivity, linearity, accuracy, and robustness. The method was found to be suitable for the quality control of meprednisone in tablets as well as the stability indicating studies.
publishDate 2009
dc.date.none.fl_str_mv 2009-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115006
Ceresole, Rita; Rosasco, María Ana; Segall, Adriana Ines; HPLC assay for meprednisone in tablets; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 32; 19; 1-2009; 2795-2804
1082-6076
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115006
identifier_str_mv Ceresole, Rita; Rosasco, María Ana; Segall, Adriana Ines; HPLC assay for meprednisone in tablets; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 32; 19; 1-2009; 2795-2804
1082-6076
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10826070903288144
info:eu-repo/semantics/altIdentifier/doi/10.1080/10826070903288144
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269776004513792
score 13.13397

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