Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity

Autores
Fu, Yingying; Cao, Rui; Schäfer, Miriam; Stephan, Sonja; Braspenning Wesch, Ilona; Schmitt, Laura; Bischoff, Ralf; Müller, Martin; Schäfer, Kai; Vinzon, Sabrina Eugenia; Rösl, Frank; Hasche, Daniel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate mouse Mastomys coucha as preclinical model, this is the first study demonstrating seroconversion against different L1 isoforms during the natural course of papillomavirus infection. Intriguingly, positivity with the cutaneous MnPV was accompanied by a strong seroresponse against a longer L1 isoform, but to our surprise, the raised antibodies were non-neutralizing. Only after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to successfully establish an infection. This argues for a novel humoral immune escape mechanism that may also have important implications on the interpretation of epidemiological data in terms of seropositivity and protection of PV infections in general.
Fil: Fu, Yingying. German Cancer Research Center; Alemania
Fil: Cao, Rui. German Cancer Research Center; Alemania
Fil: Schäfer, Miriam. German Cancer Research Center; Alemania
Fil: Stephan, Sonja. German Cancer Research Center; Alemania
Fil: Braspenning Wesch, Ilona. German Cancer Research Center; Alemania
Fil: Schmitt, Laura. German Cancer Research Center; Alemania
Fil: Bischoff, Ralf. German Cancer Research Center; Alemania
Fil: Müller, Martin. German Cancer Research Center; Alemania
Fil: Schäfer, Kai. German Cancer Research Center; Alemania
Fil: Vinzon, Sabrina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Rösl, Frank. German Cancer Research Center; Alemania
Fil: Hasche, Daniel. German Cancer Research Center ; Alemania
Materia
papillomavirus
immune escape
Mastomys coucha
seroconversion
neutralization
virus-like particle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/139202
Acceder
id CONICETDig_7b7b2bd743efa52fd228f184df3c90df
oai_identifier_str oai:ri.conicet.gov.ar:11336/139202
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunityFu, YingyingCao, RuiSchäfer, MiriamStephan, SonjaBraspenning Wesch, IlonaSchmitt, LauraBischoff, RalfMüller, MartinSchäfer, KaiVinzon, Sabrina EugeniaRösl, FrankHasche, Danielpapillomavirusimmune escapeMastomys couchaseroconversionneutralizationvirus-like particlehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate mouse Mastomys coucha as preclinical model, this is the first study demonstrating seroconversion against different L1 isoforms during the natural course of papillomavirus infection. Intriguingly, positivity with the cutaneous MnPV was accompanied by a strong seroresponse against a longer L1 isoform, but to our surprise, the raised antibodies were non-neutralizing. Only after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to successfully establish an infection. This argues for a novel humoral immune escape mechanism that may also have important implications on the interpretation of epidemiological data in terms of seropositivity and protection of PV infections in general.Fil: Fu, Yingying. German Cancer Research Center; AlemaniaFil: Cao, Rui. German Cancer Research Center; AlemaniaFil: Schäfer, Miriam. German Cancer Research Center; AlemaniaFil: Stephan, Sonja. German Cancer Research Center; AlemaniaFil: Braspenning Wesch, Ilona. German Cancer Research Center; AlemaniaFil: Schmitt, Laura. German Cancer Research Center; AlemaniaFil: Bischoff, Ralf. German Cancer Research Center; AlemaniaFil: Müller, Martin. German Cancer Research Center; AlemaniaFil: Schäfer, Kai. German Cancer Research Center; AlemaniaFil: Vinzon, Sabrina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Rösl, Frank. German Cancer Research Center; AlemaniaFil: Hasche, Daniel. German Cancer Research Center ; AlemaniaeLife Sciences2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139202Fu, Yingying; Cao, Rui; Schäfer, Miriam; Stephan, Sonja; Braspenning Wesch, Ilona; et al.; Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity; eLife Sciences; eLife; 9; 8-2020; 1-262050-084X2050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/57626info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.57626info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:21Zoai:ri.conicet.gov.ar:11336/139202instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:21.881CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
title Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
spellingShingle Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
Fu, Yingying
papillomavirus
immune escape
Mastomys coucha
seroconversion
neutralization
virus-like particle
title_short Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
title_full Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
title_fullStr Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
title_full_unstemmed Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
title_sort Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
dc.creator.none.fl_str_mv Fu, Yingying
Cao, Rui
Schäfer, Miriam
Stephan, Sonja
Braspenning Wesch, Ilona
Schmitt, Laura
Bischoff, Ralf
Müller, Martin
Schäfer, Kai
Vinzon, Sabrina Eugenia
Rösl, Frank
Hasche, Daniel
author Fu, Yingying
author_facet Fu, Yingying
Cao, Rui
Schäfer, Miriam
Stephan, Sonja
Braspenning Wesch, Ilona
Schmitt, Laura
Bischoff, Ralf
Müller, Martin
Schäfer, Kai
Vinzon, Sabrina Eugenia
Rösl, Frank
Hasche, Daniel
author_role author
author2 Cao, Rui
Schäfer, Miriam
Stephan, Sonja
Braspenning Wesch, Ilona
Schmitt, Laura
Bischoff, Ralf
Müller, Martin
Schäfer, Kai
Vinzon, Sabrina Eugenia
Rösl, Frank
Hasche, Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv papillomavirus
immune escape
Mastomys coucha
seroconversion
neutralization
virus-like particle
topic papillomavirus
immune escape
Mastomys coucha
seroconversion
neutralization
virus-like particle
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate mouse Mastomys coucha as preclinical model, this is the first study demonstrating seroconversion against different L1 isoforms during the natural course of papillomavirus infection. Intriguingly, positivity with the cutaneous MnPV was accompanied by a strong seroresponse against a longer L1 isoform, but to our surprise, the raised antibodies were non-neutralizing. Only after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to successfully establish an infection. This argues for a novel humoral immune escape mechanism that may also have important implications on the interpretation of epidemiological data in terms of seropositivity and protection of PV infections in general.
Fil: Fu, Yingying. German Cancer Research Center; Alemania
Fil: Cao, Rui. German Cancer Research Center; Alemania
Fil: Schäfer, Miriam. German Cancer Research Center; Alemania
Fil: Stephan, Sonja. German Cancer Research Center; Alemania
Fil: Braspenning Wesch, Ilona. German Cancer Research Center; Alemania
Fil: Schmitt, Laura. German Cancer Research Center; Alemania
Fil: Bischoff, Ralf. German Cancer Research Center; Alemania
Fil: Müller, Martin. German Cancer Research Center; Alemania
Fil: Schäfer, Kai. German Cancer Research Center; Alemania
Fil: Vinzon, Sabrina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Rösl, Frank. German Cancer Research Center; Alemania
Fil: Hasche, Daniel. German Cancer Research Center ; Alemania
description Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate mouse Mastomys coucha as preclinical model, this is the first study demonstrating seroconversion against different L1 isoforms during the natural course of papillomavirus infection. Intriguingly, positivity with the cutaneous MnPV was accompanied by a strong seroresponse against a longer L1 isoform, but to our surprise, the raised antibodies were non-neutralizing. Only after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to successfully establish an infection. This argues for a novel humoral immune escape mechanism that may also have important implications on the interpretation of epidemiological data in terms of seropositivity and protection of PV infections in general.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139202
Fu, Yingying; Cao, Rui; Schäfer, Miriam; Stephan, Sonja; Braspenning Wesch, Ilona; et al.; Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity; eLife Sciences; eLife; 9; 8-2020; 1-26
2050-084X
2050-084X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139202
identifier_str_mv Fu, Yingying; Cao, Rui; Schäfer, Miriam; Stephan, Sonja; Braspenning Wesch, Ilona; et al.; Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity; eLife Sciences; eLife; 9; 8-2020; 1-26
2050-084X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/57626
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.57626
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences
publisher.none.fl_str_mv eLife Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614088720646144
score 13.070432

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