α-Conotoxins
- Autores
- Arias, Hugo Rubén; Blanton, Michael P
- Año de publicación
- 2000
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- α-Conotoxins (α-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) α-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and even among distinct AChR subtypes; (2) the binding sites for α-CgTxs are located, like other cholinergic ligands, at the interface of α and non-α subunits (γ, δ, and ε for the muscle-type AChR, and β for several neuronal-type AChRs); (3) some α-CgTxs differentiate the high- from the low-affinity binding site found on either α/non-α subunit interface; and that (4) specific residues in the cholinergic binding site are energetically coupled with their corresponding pairs in the toxin stabilizing the α-CgTx-AChR complex. The α-CgTxs have proven to be excellent probes for studying the structure and function of the AChR family.
Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina. Texas Teach University Health Sciences Center; Estados Unidos
Fil: Blanton, Michael P. Texas Teach University Health Sciences Center; Estados Unidos - Materia
-
Α-Conotoxins
Competitive Antagonists
Nicotinic Acetylcholine Receptors - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/78993
Ver los metadatos del registro completo
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α-ConotoxinsArias, Hugo RubénBlanton, Michael PΑ-ConotoxinsCompetitive AntagonistsNicotinic Acetylcholine Receptorshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3α-Conotoxins (α-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) α-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and even among distinct AChR subtypes; (2) the binding sites for α-CgTxs are located, like other cholinergic ligands, at the interface of α and non-α subunits (γ, δ, and ε for the muscle-type AChR, and β for several neuronal-type AChRs); (3) some α-CgTxs differentiate the high- from the low-affinity binding site found on either α/non-α subunit interface; and that (4) specific residues in the cholinergic binding site are energetically coupled with their corresponding pairs in the toxin stabilizing the α-CgTx-AChR complex. The α-CgTxs have proven to be excellent probes for studying the structure and function of the AChR family.Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina. Texas Teach University Health Sciences Center; Estados UnidosFil: Blanton, Michael P. Texas Teach University Health Sciences Center; Estados UnidosPergamon-Elsevier Science Ltd2000-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78993Arias, Hugo Rubén; Blanton, Michael P; α-Conotoxins; Pergamon-Elsevier Science Ltd; International Journal of Biochemistry and Cellular Biology; 32; 10; 8-2000; 1017-10281357-2725CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1357272500000510?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S1357-2725(00)00051-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:25Zoai:ri.conicet.gov.ar:11336/78993instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:25.806CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
α-Conotoxins |
| title |
α-Conotoxins |
| spellingShingle |
α-Conotoxins Arias, Hugo Rubén Α-Conotoxins Competitive Antagonists Nicotinic Acetylcholine Receptors |
| title_short |
α-Conotoxins |
| title_full |
α-Conotoxins |
| title_fullStr |
α-Conotoxins |
| title_full_unstemmed |
α-Conotoxins |
| title_sort |
α-Conotoxins |
| dc.creator.none.fl_str_mv |
Arias, Hugo Rubén Blanton, Michael P |
| author |
Arias, Hugo Rubén |
| author_facet |
Arias, Hugo Rubén Blanton, Michael P |
| author_role |
author |
| author2 |
Blanton, Michael P |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
Α-Conotoxins Competitive Antagonists Nicotinic Acetylcholine Receptors |
| topic |
Α-Conotoxins Competitive Antagonists Nicotinic Acetylcholine Receptors |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
α-Conotoxins (α-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) α-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and even among distinct AChR subtypes; (2) the binding sites for α-CgTxs are located, like other cholinergic ligands, at the interface of α and non-α subunits (γ, δ, and ε for the muscle-type AChR, and β for several neuronal-type AChRs); (3) some α-CgTxs differentiate the high- from the low-affinity binding site found on either α/non-α subunit interface; and that (4) specific residues in the cholinergic binding site are energetically coupled with their corresponding pairs in the toxin stabilizing the α-CgTx-AChR complex. The α-CgTxs have proven to be excellent probes for studying the structure and function of the AChR family. Fil: Arias, Hugo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina. Texas Teach University Health Sciences Center; Estados Unidos Fil: Blanton, Michael P. Texas Teach University Health Sciences Center; Estados Unidos |
| description |
α-Conotoxins (α-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) α-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and even among distinct AChR subtypes; (2) the binding sites for α-CgTxs are located, like other cholinergic ligands, at the interface of α and non-α subunits (γ, δ, and ε for the muscle-type AChR, and β for several neuronal-type AChRs); (3) some α-CgTxs differentiate the high- from the low-affinity binding site found on either α/non-α subunit interface; and that (4) specific residues in the cholinergic binding site are energetically coupled with their corresponding pairs in the toxin stabilizing the α-CgTx-AChR complex. The α-CgTxs have proven to be excellent probes for studying the structure and function of the AChR family. |
| publishDate |
2000 |
| dc.date.none.fl_str_mv |
2000-08 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/78993 Arias, Hugo Rubén; Blanton, Michael P; α-Conotoxins; Pergamon-Elsevier Science Ltd; International Journal of Biochemistry and Cellular Biology; 32; 10; 8-2000; 1017-1028 1357-2725 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/78993 |
| identifier_str_mv |
Arias, Hugo Rubén; Blanton, Michael P; α-Conotoxins; Pergamon-Elsevier Science Ltd; International Journal of Biochemistry and Cellular Biology; 32; 10; 8-2000; 1017-1028 1357-2725 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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Pergamon-Elsevier Science Ltd |
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