Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species

Autores
Gómez, Analia de Los Angeles; Terán Baptista, Zareath Pamela; Mandova ,Tzvetelina; Barouti,Angeliki; Kritsanida, Marina; Grougnet Raphael; Vattuone, Marta Amelia; Sampietro, Diego Alejandro
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Extracts from aerial parts of Prosopis ruscifolia, Bidens pilosa, Cercidium praecox and Phoradendron liga were assayed against toxigenic Aspergillus species. They were obtained by sequential extraction of the aerial parts with hexane (fHex), dichloromethane (fDCM), ethyl acetate (fEtOAc) and methanol (fMeOH). The fMeOH from P. ruscifolia showed the highest antifungal spectrum (MIC = 750–1500 µg mL−1; MID = 50–200 µg; DI = 1.7–3.0 mm). Indolizidine alkaloids (juliflorine and juliprosine) and tryptamine were identified with strong (MIC = 188 µg mL−1) and moderate antifungal activities (MIC = 750 µg mL−1), respectively, towards A. parasiticus and A. flavus. The fMeOH, the indolizidine alkaloids and tryptamine synergized the fungitoxic effect of potassium sorbate and propiconazole. They completely suppressed the biosynthesis of aflatoxins at concentrations of 47, 94 and 375 µg mL−1, respectively. Our results indicate that fMeOH and its identified alkaloids are promisory additives of commercial antifungals and are antiaflatoxigenic agents at concentrations below of those required for complete suppression of fungal growth.
Fil: Gómez, Analia de Los Angeles. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Terán Baptista, Zareath Pamela. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Mandova ,Tzvetelina. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Barouti,Angeliki. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Kritsanida, Marina. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Grougnet Raphael. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Materia
Alkalois
Antifungal
Antiaflatoxigenic
Aspergillus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81061
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/81061
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus speciesGómez, Analia de Los AngelesTerán Baptista, Zareath PamelaMandova ,TzvetelinaBarouti,AngelikiKritsanida, MarinaGrougnet RaphaelVattuone, Marta AmeliaSampietro, Diego AlejandroAlkaloisAntifungalAntiaflatoxigenicAspergillushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Extracts from aerial parts of Prosopis ruscifolia, Bidens pilosa, Cercidium praecox and Phoradendron liga were assayed against toxigenic Aspergillus species. They were obtained by sequential extraction of the aerial parts with hexane (fHex), dichloromethane (fDCM), ethyl acetate (fEtOAc) and methanol (fMeOH). The fMeOH from P. ruscifolia showed the highest antifungal spectrum (MIC = 750–1500 µg mL−1; MID = 50–200 µg; DI = 1.7–3.0 mm). Indolizidine alkaloids (juliflorine and juliprosine) and tryptamine were identified with strong (MIC = 188 µg mL−1) and moderate antifungal activities (MIC = 750 µg mL−1), respectively, towards A. parasiticus and A. flavus. The fMeOH, the indolizidine alkaloids and tryptamine synergized the fungitoxic effect of potassium sorbate and propiconazole. They completely suppressed the biosynthesis of aflatoxins at concentrations of 47, 94 and 375 µg mL−1, respectively. Our results indicate that fMeOH and its identified alkaloids are promisory additives of commercial antifungals and are antiaflatoxigenic agents at concentrations below of those required for complete suppression of fungal growth.Fil: Gómez, Analia de Los Angeles. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Terán Baptista, Zareath Pamela. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Mandova ,Tzvetelina. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; FranciaFil: Barouti,Angeliki. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; FranciaFil: Kritsanida, Marina. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; FranciaFil: Grougnet Raphael. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; FranciaFil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaTaylor & Francis Ltd2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81061Gómez, Analia de Los Angeles; Terán Baptista, Zareath Pamela; Mandova ,Tzvetelina; Barouti,Angeliki; Kritsanida, Marina; et al.; Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species; Taylor & Francis Ltd; Natural Product Research; 11-2018; 1-51478-6419CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2018.1560286info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1560286info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:40:39Zoai:ri.conicet.gov.ar:11336/81061instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:40:39.393CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
title Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
spellingShingle Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
Gómez, Analia de Los Angeles
Alkalois
Antifungal
Antiaflatoxigenic
Aspergillus
title_short Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
title_full Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
title_fullStr Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
title_full_unstemmed Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
title_sort Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species
dc.creator.none.fl_str_mv Gómez, Analia de Los Angeles
Terán Baptista, Zareath Pamela
Mandova ,Tzvetelina
Barouti,Angeliki
Kritsanida, Marina
Grougnet Raphael
Vattuone, Marta Amelia
Sampietro, Diego Alejandro
author Gómez, Analia de Los Angeles
author_facet Gómez, Analia de Los Angeles
Terán Baptista, Zareath Pamela
Mandova ,Tzvetelina
Barouti,Angeliki
Kritsanida, Marina
Grougnet Raphael
Vattuone, Marta Amelia
Sampietro, Diego Alejandro
author_role author
author2 Terán Baptista, Zareath Pamela
Mandova ,Tzvetelina
Barouti,Angeliki
Kritsanida, Marina
Grougnet Raphael
Vattuone, Marta Amelia
Sampietro, Diego Alejandro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alkalois
Antifungal
Antiaflatoxigenic
Aspergillus
topic Alkalois
Antifungal
Antiaflatoxigenic
Aspergillus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Extracts from aerial parts of Prosopis ruscifolia, Bidens pilosa, Cercidium praecox and Phoradendron liga were assayed against toxigenic Aspergillus species. They were obtained by sequential extraction of the aerial parts with hexane (fHex), dichloromethane (fDCM), ethyl acetate (fEtOAc) and methanol (fMeOH). The fMeOH from P. ruscifolia showed the highest antifungal spectrum (MIC = 750–1500 µg mL−1; MID = 50–200 µg; DI = 1.7–3.0 mm). Indolizidine alkaloids (juliflorine and juliprosine) and tryptamine were identified with strong (MIC = 188 µg mL−1) and moderate antifungal activities (MIC = 750 µg mL−1), respectively, towards A. parasiticus and A. flavus. The fMeOH, the indolizidine alkaloids and tryptamine synergized the fungitoxic effect of potassium sorbate and propiconazole. They completely suppressed the biosynthesis of aflatoxins at concentrations of 47, 94 and 375 µg mL−1, respectively. Our results indicate that fMeOH and its identified alkaloids are promisory additives of commercial antifungals and are antiaflatoxigenic agents at concentrations below of those required for complete suppression of fungal growth.
Fil: Gómez, Analia de Los Angeles. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Terán Baptista, Zareath Pamela. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Mandova ,Tzvetelina. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Barouti,Angeliki. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Kritsanida, Marina. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Grougnet Raphael. 2laboratoire de Pharmacognosie, Umr/cnrs 8638 Comete, U; Francia
Fil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
description Extracts from aerial parts of Prosopis ruscifolia, Bidens pilosa, Cercidium praecox and Phoradendron liga were assayed against toxigenic Aspergillus species. They were obtained by sequential extraction of the aerial parts with hexane (fHex), dichloromethane (fDCM), ethyl acetate (fEtOAc) and methanol (fMeOH). The fMeOH from P. ruscifolia showed the highest antifungal spectrum (MIC = 750–1500 µg mL−1; MID = 50–200 µg; DI = 1.7–3.0 mm). Indolizidine alkaloids (juliflorine and juliprosine) and tryptamine were identified with strong (MIC = 188 µg mL−1) and moderate antifungal activities (MIC = 750 µg mL−1), respectively, towards A. parasiticus and A. flavus. The fMeOH, the indolizidine alkaloids and tryptamine synergized the fungitoxic effect of potassium sorbate and propiconazole. They completely suppressed the biosynthesis of aflatoxins at concentrations of 47, 94 and 375 µg mL−1, respectively. Our results indicate that fMeOH and its identified alkaloids are promisory additives of commercial antifungals and are antiaflatoxigenic agents at concentrations below of those required for complete suppression of fungal growth.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81061
Gómez, Analia de Los Angeles; Terán Baptista, Zareath Pamela; Mandova ,Tzvetelina; Barouti,Angeliki; Kritsanida, Marina; et al.; Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species; Taylor & Francis Ltd; Natural Product Research; 11-2018; 1-5
1478-6419
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81061
identifier_str_mv Gómez, Analia de Los Angeles; Terán Baptista, Zareath Pamela; Mandova ,Tzvetelina; Barouti,Angeliki; Kritsanida, Marina; et al.; Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species; Taylor & Francis Ltd; Natural Product Research; 11-2018; 1-5
1478-6419
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2018.1560286
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1560286
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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