Test–retest reliability of the Friedreich’s ataxia rating scale

Autores
Rummey, Christian; Zesiewicz, Theresa A.; Perez Lloret, Santiago; Farmer, Jennifer M.; Pandolfo, Massimo; Lynch, David R.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.
Fil: Rummey, Christian. Clinical Data Science Gmbh; Suiza
Fil: Zesiewicz, Theresa A.. University of South Florida; Argentina
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Farmer, Jennifer M.. Friedreich Ataxia Research Alliance; Estados Unidos
Fil: Pandolfo, Massimo. Université Libre de Bruxelles; Bélgica
Fil: Lynch, David R.. Children’s Hospital of Philadelphia; Estados Unidos
Materia
Ataxia de Friedreich
escala subjectiva de evaluación
validación
reproducibilidad
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170572
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Test–retest reliability of the Friedreich’s ataxia rating scaleRummey, ChristianZesiewicz, Theresa A.Perez Lloret, SantiagoFarmer, Jennifer M.Pandolfo, MassimoLynch, David R.Ataxia de Friedreichescala subjectiva de evaluaciónvalidaciónreproducibilidadhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.Fil: Rummey, Christian. Clinical Data Science Gmbh; SuizaFil: Zesiewicz, Theresa A.. University of South Florida; ArgentinaFil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Farmer, Jennifer M.. Friedreich Ataxia Research Alliance; Estados UnidosFil: Pandolfo, Massimo. Université Libre de Bruxelles; BélgicaFil: Lynch, David R.. Children’s Hospital of Philadelphia; Estados UnidosWiley Blackwell Publishing, Inc2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170572Rummey, Christian; Zesiewicz, Theresa A.; Perez Lloret, Santiago; Farmer, Jennifer M.; Pandolfo, Massimo; et al.; Test–retest reliability of the Friedreich’s ataxia rating scale; Wiley Blackwell Publishing, Inc; Annals of Clinical and Translational Neurology; 7; 9; 9-2020; 1708-17122328-9503CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/acn3.51118info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/acn3.51118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:08Zoai:ri.conicet.gov.ar:11336/170572instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:08.952CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Test–retest reliability of the Friedreich’s ataxia rating scale
title Test–retest reliability of the Friedreich’s ataxia rating scale
spellingShingle Test–retest reliability of the Friedreich’s ataxia rating scale
Rummey, Christian
Ataxia de Friedreich
escala subjectiva de evaluación
validación
reproducibilidad
title_short Test–retest reliability of the Friedreich’s ataxia rating scale
title_full Test–retest reliability of the Friedreich’s ataxia rating scale
title_fullStr Test–retest reliability of the Friedreich’s ataxia rating scale
title_full_unstemmed Test–retest reliability of the Friedreich’s ataxia rating scale
title_sort Test–retest reliability of the Friedreich’s ataxia rating scale
dc.creator.none.fl_str_mv Rummey, Christian
Zesiewicz, Theresa A.
Perez Lloret, Santiago
Farmer, Jennifer M.
Pandolfo, Massimo
Lynch, David R.
author Rummey, Christian
author_facet Rummey, Christian
Zesiewicz, Theresa A.
Perez Lloret, Santiago
Farmer, Jennifer M.
Pandolfo, Massimo
Lynch, David R.
author_role author
author2 Zesiewicz, Theresa A.
Perez Lloret, Santiago
Farmer, Jennifer M.
Pandolfo, Massimo
Lynch, David R.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ataxia de Friedreich
escala subjectiva de evaluación
validación
reproducibilidad
topic Ataxia de Friedreich
escala subjectiva de evaluación
validación
reproducibilidad
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.
Fil: Rummey, Christian. Clinical Data Science Gmbh; Suiza
Fil: Zesiewicz, Theresa A.. University of South Florida; Argentina
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Farmer, Jennifer M.. Friedreich Ataxia Research Alliance; Estados Unidos
Fil: Pandolfo, Massimo. Université Libre de Bruxelles; Bélgica
Fil: Lynch, David R.. Children’s Hospital of Philadelphia; Estados Unidos
description The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it’s validity in measuring disease progression, formal test–retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test–retest reliability of the mFARS, and it’s upright stability subscore.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170572
Rummey, Christian; Zesiewicz, Theresa A.; Perez Lloret, Santiago; Farmer, Jennifer M.; Pandolfo, Massimo; et al.; Test–retest reliability of the Friedreich’s ataxia rating scale; Wiley Blackwell Publishing, Inc; Annals of Clinical and Translational Neurology; 7; 9; 9-2020; 1708-1712
2328-9503
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170572
identifier_str_mv Rummey, Christian; Zesiewicz, Theresa A.; Perez Lloret, Santiago; Farmer, Jennifer M.; Pandolfo, Massimo; et al.; Test–retest reliability of the Friedreich’s ataxia rating scale; Wiley Blackwell Publishing, Inc; Annals of Clinical and Translational Neurology; 7; 9; 9-2020; 1708-1712
2328-9503
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/acn3.51118
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/acn3.51118
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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