Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test

Autores
Goris, N.; Maradei, E.; D`Aloia, R.; Fondevilla, N.; Mattion, Nora Marta; Perez, A.; Smitsaart, E.; Nauwynck, H.; la Torre, Jose Leonardo; Palma, E.; De Clerck, K.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species. The objective of the study was to determine the precision of the in vivo "Protection against Podal Generalisation" (PPG) FMD vaccine potency test in cattle using homologous (vaccine quality control) and heterologous (vaccine matching) viral challenge. The overall level of protection induced by the A24 Cruzeiro/Brazil/55 vaccine used in six homologous PPG tests was 88.5%. Vaccine accordance (VACC) and vaccine concordance (VCON) were estimated to be 75.9% and 73.7%, respectively. In four heterologous challenge PPG tests, the overall level of cross-protection induced by the A24 Cruzeiro/Brazil/55 vaccine against A Argentina/2001 challenge was 26.6%, with VACC and VCON values of 65.7% and 59.2%, respectively. Results indicate that the homologous PPG test is more reliable than the European Pharmacopoeia potency test, but that a larger number of animals should be used in order to increase the test's statistical power. In this regard, indirect alternative tests for vaccine potency and vaccine matching merit consideration. © 2008 Elsevier Ltd. All rights reserved.
Fil: Goris, N.. Veterinary and Agrochemical Research Centre; Bélgica
Fil: Maradei, E.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Servicio Nacional de Sanidad Animal; Argentina
Fil: D`Aloia, R.. Servicio Nacional de Sanidad Animal; Argentina
Fil: Fondevilla, N.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina
Fil: Mattion, Nora Marta. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Animal; Argentina
Fil: Perez, A.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Servicio Nacional de Sanidad Animal; Argentina
Fil: Smitsaart, E.. Biogenesis Bago S.a..; Argentina. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina
Fil: Nauwynck, H.. University of Ghent; Bélgica
Fil: la Torre, Jose Leonardo. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Animal; Argentina
Fil: Palma, E.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina
Fil: De Clerck, K.. Veterinary and Agrochemical Research Centre, Virology Department, Section of Epizootic Diseases; Argentina
Materia
FOOT-AND-MOUTH DISEASE
PRECISION
VACCINE POTENCY
VACCINE STRAIN SELECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184547
Acceder
id CONICETDig_7700653310e64653b0b0f9998ad5aa25
oai_identifier_str oai:ri.conicet.gov.ar:11336/184547
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" testGoris, N.Maradei, E.D`Aloia, R.Fondevilla, N.Mattion, Nora MartaPerez, A.Smitsaart, E.Nauwynck, H.la Torre, Jose LeonardoPalma, E.De Clerck, K.FOOT-AND-MOUTH DISEASEPRECISIONVACCINE POTENCYVACCINE STRAIN SELECTIONhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species. The objective of the study was to determine the precision of the in vivo "Protection against Podal Generalisation" (PPG) FMD vaccine potency test in cattle using homologous (vaccine quality control) and heterologous (vaccine matching) viral challenge. The overall level of protection induced by the A24 Cruzeiro/Brazil/55 vaccine used in six homologous PPG tests was 88.5%. Vaccine accordance (VACC) and vaccine concordance (VCON) were estimated to be 75.9% and 73.7%, respectively. In four heterologous challenge PPG tests, the overall level of cross-protection induced by the A24 Cruzeiro/Brazil/55 vaccine against A Argentina/2001 challenge was 26.6%, with VACC and VCON values of 65.7% and 59.2%, respectively. Results indicate that the homologous PPG test is more reliable than the European Pharmacopoeia potency test, but that a larger number of animals should be used in order to increase the test's statistical power. In this regard, indirect alternative tests for vaccine potency and vaccine matching merit consideration. © 2008 Elsevier Ltd. All rights reserved.Fil: Goris, N.. Veterinary and Agrochemical Research Centre; BélgicaFil: Maradei, E.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Servicio Nacional de Sanidad Animal; ArgentinaFil: D`Aloia, R.. Servicio Nacional de Sanidad Animal; ArgentinaFil: Fondevilla, N.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; ArgentinaFil: Mattion, Nora Marta. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Animal; ArgentinaFil: Perez, A.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Servicio Nacional de Sanidad Animal; ArgentinaFil: Smitsaart, E.. Biogenesis Bago S.a..; Argentina. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; ArgentinaFil: Nauwynck, H.. University of Ghent; BélgicaFil: la Torre, Jose Leonardo. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Animal; ArgentinaFil: Palma, E.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; ArgentinaFil: De Clerck, K.. Veterinary and Agrochemical Research Centre, Virology Department, Section of Epizootic Diseases; ArgentinaElsevier2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184547Goris, N.; Maradei, E.; D`Aloia, R.; Fondevilla, N.; Mattion, Nora Marta; et al.; Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test; Elsevier; Vaccine; 26; 27-28; 12-2008; 3432-34370264-410XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0264410X08004878info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vaccine.2008.04.034info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:22Zoai:ri.conicet.gov.ar:11336/184547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:22.567CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
title Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
spellingShingle Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
Goris, N.
FOOT-AND-MOUTH DISEASE
PRECISION
VACCINE POTENCY
VACCINE STRAIN SELECTION
title_short Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
title_full Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
title_fullStr Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
title_full_unstemmed Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
title_sort Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test
dc.creator.none.fl_str_mv Goris, N.
Maradei, E.
D`Aloia, R.
Fondevilla, N.
Mattion, Nora Marta
Perez, A.
Smitsaart, E.
Nauwynck, H.
la Torre, Jose Leonardo
Palma, E.
De Clerck, K.
author Goris, N.
author_facet Goris, N.
Maradei, E.
D`Aloia, R.
Fondevilla, N.
Mattion, Nora Marta
Perez, A.
Smitsaart, E.
Nauwynck, H.
la Torre, Jose Leonardo
Palma, E.
De Clerck, K.
author_role author
author2 Maradei, E.
D`Aloia, R.
Fondevilla, N.
Mattion, Nora Marta
Perez, A.
Smitsaart, E.
Nauwynck, H.
la Torre, Jose Leonardo
Palma, E.
De Clerck, K.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FOOT-AND-MOUTH DISEASE
PRECISION
VACCINE POTENCY
VACCINE STRAIN SELECTION
topic FOOT-AND-MOUTH DISEASE
PRECISION
VACCINE POTENCY
VACCINE STRAIN SELECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species. The objective of the study was to determine the precision of the in vivo "Protection against Podal Generalisation" (PPG) FMD vaccine potency test in cattle using homologous (vaccine quality control) and heterologous (vaccine matching) viral challenge. The overall level of protection induced by the A24 Cruzeiro/Brazil/55 vaccine used in six homologous PPG tests was 88.5%. Vaccine accordance (VACC) and vaccine concordance (VCON) were estimated to be 75.9% and 73.7%, respectively. In four heterologous challenge PPG tests, the overall level of cross-protection induced by the A24 Cruzeiro/Brazil/55 vaccine against A Argentina/2001 challenge was 26.6%, with VACC and VCON values of 65.7% and 59.2%, respectively. Results indicate that the homologous PPG test is more reliable than the European Pharmacopoeia potency test, but that a larger number of animals should be used in order to increase the test's statistical power. In this regard, indirect alternative tests for vaccine potency and vaccine matching merit consideration. © 2008 Elsevier Ltd. All rights reserved.
Fil: Goris, N.. Veterinary and Agrochemical Research Centre; Bélgica
Fil: Maradei, E.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Servicio Nacional de Sanidad Animal; Argentina
Fil: D`Aloia, R.. Servicio Nacional de Sanidad Animal; Argentina
Fil: Fondevilla, N.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina
Fil: Mattion, Nora Marta. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Animal; Argentina
Fil: Perez, A.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina. Servicio Nacional de Sanidad Animal; Argentina
Fil: Smitsaart, E.. Biogenesis Bago S.a..; Argentina. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina
Fil: Nauwynck, H.. University of Ghent; Bélgica
Fil: la Torre, Jose Leonardo. Ministerio de Producción y Trabajo. Secretaría de Gobierno de Agroindustria. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Centro de Virología Animal. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Virología Animal; Argentina
Fil: Palma, E.. Argentine FMD Interinstitutional Network for Research and Development in Foot-and-mouth Disease; Argentina
Fil: De Clerck, K.. Veterinary and Agrochemical Research Centre, Virology Department, Section of Epizootic Diseases; Argentina
description The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species. The objective of the study was to determine the precision of the in vivo "Protection against Podal Generalisation" (PPG) FMD vaccine potency test in cattle using homologous (vaccine quality control) and heterologous (vaccine matching) viral challenge. The overall level of protection induced by the A24 Cruzeiro/Brazil/55 vaccine used in six homologous PPG tests was 88.5%. Vaccine accordance (VACC) and vaccine concordance (VCON) were estimated to be 75.9% and 73.7%, respectively. In four heterologous challenge PPG tests, the overall level of cross-protection induced by the A24 Cruzeiro/Brazil/55 vaccine against A Argentina/2001 challenge was 26.6%, with VACC and VCON values of 65.7% and 59.2%, respectively. Results indicate that the homologous PPG test is more reliable than the European Pharmacopoeia potency test, but that a larger number of animals should be used in order to increase the test's statistical power. In this regard, indirect alternative tests for vaccine potency and vaccine matching merit consideration. © 2008 Elsevier Ltd. All rights reserved.
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184547
Goris, N.; Maradei, E.; D`Aloia, R.; Fondevilla, N.; Mattion, Nora Marta; et al.; Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test; Elsevier; Vaccine; 26; 27-28; 12-2008; 3432-3437
0264-410X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184547
identifier_str_mv Goris, N.; Maradei, E.; D`Aloia, R.; Fondevilla, N.; Mattion, Nora Marta; et al.; Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: Precision of the "Protection against Podal Generalisation" test; Elsevier; Vaccine; 26; 27-28; 12-2008; 3432-3437
0264-410X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0264410X08004878
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vaccine.2008.04.034
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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