Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam

Autores
Mojica, Maria F.; Papp-Wallace, Krisztina M.; Taracila, Magdalena A.; Barnes, Melissa D.; Rutter, Joseph D.; Jacobs, Michael R.; LiPuma, John J.; Walsh, Thomas J.; Vila, Alejandro Jose; Bonomo, Robert A.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.
Fil: Mojica, Maria F.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
Fil: Papp-Wallace, Krisztina M.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
Fil: Taracila, Magdalena A.. Case Western Reserve University; Estados Unidos
Fil: Barnes, Melissa D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: Rutter, Joseph D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
Fil: Jacobs, Michael R.. University Hospitals Cleveland Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: LiPuma, John J.. University of Michigan; Estados Unidos
Fil: Walsh, Thomas J.. Weill Cornell Medical Center; Estados Unidos
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Bonomo, Robert A.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados Unidos
Materia
AVIBACTAM
AZTREONAM
S. MALTOPHILIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/65900
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/65900
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonamMojica, Maria F.Papp-Wallace, Krisztina M.Taracila, Magdalena A.Barnes, Melissa D.Rutter, Joseph D.Jacobs, Michael R.LiPuma, John J.Walsh, Thomas J.Vila, Alejandro JoseBonomo, Robert A.AVIBACTAMAZTREONAMS. MALTOPHILIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.Fil: Mojica, Maria F.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados UnidosFil: Papp-Wallace, Krisztina M.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados UnidosFil: Taracila, Magdalena A.. Case Western Reserve University; Estados UnidosFil: Barnes, Melissa D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados UnidosFil: Rutter, Joseph D.. Louis Stokes Veterans Affairs Medical Center; Estados UnidosFil: Jacobs, Michael R.. University Hospitals Cleveland Medical Center; Estados Unidos. Case Western Reserve University; Estados UnidosFil: LiPuma, John J.. University of Michigan; Estados UnidosFil: Walsh, Thomas J.. Weill Cornell Medical Center; Estados UnidosFil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Bonomo, Robert A.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados UnidosAmerican Society for Microbiology2017-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65900Mojica, Maria F.; Papp-Wallace, Krisztina M.; Taracila, Magdalena A.; Barnes, Melissa D.; Rutter, Joseph D.; et al.; Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 61; 10; 9-2017; 1-50066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/61/10/e00777-17.longinfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00777-17info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:17Zoai:ri.conicet.gov.ar:11336/65900instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:18.019CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
title Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
spellingShingle Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
Mojica, Maria F.
AVIBACTAM
AZTREONAM
S. MALTOPHILIA
title_short Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
title_full Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
title_fullStr Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
title_full_unstemmed Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
title_sort Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam
dc.creator.none.fl_str_mv Mojica, Maria F.
Papp-Wallace, Krisztina M.
Taracila, Magdalena A.
Barnes, Melissa D.
Rutter, Joseph D.
Jacobs, Michael R.
LiPuma, John J.
Walsh, Thomas J.
Vila, Alejandro Jose
Bonomo, Robert A.
author Mojica, Maria F.
author_facet Mojica, Maria F.
Papp-Wallace, Krisztina M.
Taracila, Magdalena A.
Barnes, Melissa D.
Rutter, Joseph D.
Jacobs, Michael R.
LiPuma, John J.
Walsh, Thomas J.
Vila, Alejandro Jose
Bonomo, Robert A.
author_role author
author2 Papp-Wallace, Krisztina M.
Taracila, Magdalena A.
Barnes, Melissa D.
Rutter, Joseph D.
Jacobs, Michael R.
LiPuma, John J.
Walsh, Thomas J.
Vila, Alejandro Jose
Bonomo, Robert A.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AVIBACTAM
AZTREONAM
S. MALTOPHILIA
topic AVIBACTAM
AZTREONAM
S. MALTOPHILIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.
Fil: Mojica, Maria F.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
Fil: Papp-Wallace, Krisztina M.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
Fil: Taracila, Magdalena A.. Case Western Reserve University; Estados Unidos
Fil: Barnes, Melissa D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: Rutter, Joseph D.. Louis Stokes Veterans Affairs Medical Center; Estados Unidos
Fil: Jacobs, Michael R.. University Hospitals Cleveland Medical Center; Estados Unidos. Case Western Reserve University; Estados Unidos
Fil: LiPuma, John J.. University of Michigan; Estados Unidos
Fil: Walsh, Thomas J.. Weill Cornell Medical Center; Estados Unidos
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Bonomo, Robert A.. Case Western Reserve University; Estados Unidos. Louis Stokes Veterans Affairs Medical Center; Estados Unidos. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology; Estados Unidos
description Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.
publishDate 2017
dc.date.none.fl_str_mv 2017-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/65900
Mojica, Maria F.; Papp-Wallace, Krisztina M.; Taracila, Magdalena A.; Barnes, Melissa D.; Rutter, Joseph D.; et al.; Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 61; 10; 9-2017; 1-5
0066-4804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/65900
identifier_str_mv Mojica, Maria F.; Papp-Wallace, Krisztina M.; Taracila, Magdalena A.; Barnes, Melissa D.; Rutter, Joseph D.; et al.; Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 61; 10; 9-2017; 1-5
0066-4804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/61/10/e00777-17.long
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00777-17
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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