Long-term worsening of bipolar disorder related with frequency of antidepressant exposure

Autores
Strejilevich, Sergio; Martino, Diego Javier; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; Whitham, Elizabeth A.; Ghaemi, S. Nassir
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: The aim of this study of 53 persons with bipolar disorder (BD) was to evaluate the relationship between history of exposure to antidepressants (AD) and mood stabilizers (MS) and the percentage of time spent ill. METHODS: BD outpatients with more than 12 months of prospective follow- up were included. Outcome was documented using a life charting technique. Current and previous exposure to AD and MS were assessed using a scale that provides a quantitative measure of exposure to psychotropic medications. Regression models were used to correct for possible confounders. RESULTS: Previous treatment with AD was an independent predictor of polarity changes (P < .001) and mixed symptoms (P = .01). In contrast, “years of exposure to MS” was an independent predictor of time spent asymptomatic (P = .019). The ratio between exposure to AD vs MS was associated with less weeks asymptomatic (P = .03), more mixed symptomatology (P = .019), and more polarity changes (P = .001). CONCLUSIONS: Antidepressant exposure was a major predictor of mood instability in the long-term outcome of BD. The ratio used of previous exposure to AD vs MS was associated with poor outcomes, suggesting that the harmful effect of AD may be additive and related to how much they are used.
Fil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Fassi, Guillermo. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Whitham, Elizabeth A.. Tufts Medical Center; Estados Unidos
Fil: Ghaemi, S. Nassir. Tufts Medical Center; Estados Unidos
Materia
BIPOLAR DISORDER
OUTCOME
ANTIDEPRESSANTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193916
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Long-term worsening of bipolar disorder related with frequency of antidepressant exposureStrejilevich, SergioMartino, Diego JavierMarengo, ElianaIgoa, AnaFassi, GuillermoWhitham, Elizabeth A.Ghaemi, S. NassirBIPOLAR DISORDEROUTCOMEANTIDEPRESSANTShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND: The aim of this study of 53 persons with bipolar disorder (BD) was to evaluate the relationship between history of exposure to antidepressants (AD) and mood stabilizers (MS) and the percentage of time spent ill. METHODS: BD outpatients with more than 12 months of prospective follow- up were included. Outcome was documented using a life charting technique. Current and previous exposure to AD and MS were assessed using a scale that provides a quantitative measure of exposure to psychotropic medications. Regression models were used to correct for possible confounders. RESULTS: Previous treatment with AD was an independent predictor of polarity changes (P < .001) and mixed symptoms (P = .01). In contrast, “years of exposure to MS” was an independent predictor of time spent asymptomatic (P = .019). The ratio between exposure to AD vs MS was associated with less weeks asymptomatic (P = .03), more mixed symptomatology (P = .019), and more polarity changes (P = .001). CONCLUSIONS: Antidepressant exposure was a major predictor of mood instability in the long-term outcome of BD. The ratio used of previous exposure to AD vs MS was associated with poor outcomes, suggesting that the harmful effect of AD may be additive and related to how much they are used.Fil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Fassi, Guillermo. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Whitham, Elizabeth A.. Tufts Medical Center; Estados UnidosFil: Ghaemi, S. Nassir. Tufts Medical Center; Estados UnidosInforma Healthcare2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193916Strejilevich, Sergio; Martino, Diego Javier; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; et al.; Long-term worsening of bipolar disorder related with frequency of antidepressant exposure; Informa Healthcare; Annals Of Clinical Psychiatry; 23; 3; 8-2011; 186-1921040-1237CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:17Zoai:ri.conicet.gov.ar:11336/193916instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:17.547CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
title Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
spellingShingle Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
Strejilevich, Sergio
BIPOLAR DISORDER
OUTCOME
ANTIDEPRESSANTS
title_short Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
title_full Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
title_fullStr Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
title_full_unstemmed Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
title_sort Long-term worsening of bipolar disorder related with frequency of antidepressant exposure
dc.creator.none.fl_str_mv Strejilevich, Sergio
Martino, Diego Javier
Marengo, Eliana
Igoa, Ana
Fassi, Guillermo
Whitham, Elizabeth A.
Ghaemi, S. Nassir
author Strejilevich, Sergio
author_facet Strejilevich, Sergio
Martino, Diego Javier
Marengo, Eliana
Igoa, Ana
Fassi, Guillermo
Whitham, Elizabeth A.
Ghaemi, S. Nassir
author_role author
author2 Martino, Diego Javier
Marengo, Eliana
Igoa, Ana
Fassi, Guillermo
Whitham, Elizabeth A.
Ghaemi, S. Nassir
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIPOLAR DISORDER
OUTCOME
ANTIDEPRESSANTS
topic BIPOLAR DISORDER
OUTCOME
ANTIDEPRESSANTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: The aim of this study of 53 persons with bipolar disorder (BD) was to evaluate the relationship between history of exposure to antidepressants (AD) and mood stabilizers (MS) and the percentage of time spent ill. METHODS: BD outpatients with more than 12 months of prospective follow- up were included. Outcome was documented using a life charting technique. Current and previous exposure to AD and MS were assessed using a scale that provides a quantitative measure of exposure to psychotropic medications. Regression models were used to correct for possible confounders. RESULTS: Previous treatment with AD was an independent predictor of polarity changes (P < .001) and mixed symptoms (P = .01). In contrast, “years of exposure to MS” was an independent predictor of time spent asymptomatic (P = .019). The ratio between exposure to AD vs MS was associated with less weeks asymptomatic (P = .03), more mixed symptomatology (P = .019), and more polarity changes (P = .001). CONCLUSIONS: Antidepressant exposure was a major predictor of mood instability in the long-term outcome of BD. The ratio used of previous exposure to AD vs MS was associated with poor outcomes, suggesting that the harmful effect of AD may be additive and related to how much they are used.
Fil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Fassi, Guillermo. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Whitham, Elizabeth A.. Tufts Medical Center; Estados Unidos
Fil: Ghaemi, S. Nassir. Tufts Medical Center; Estados Unidos
description BACKGROUND: The aim of this study of 53 persons with bipolar disorder (BD) was to evaluate the relationship between history of exposure to antidepressants (AD) and mood stabilizers (MS) and the percentage of time spent ill. METHODS: BD outpatients with more than 12 months of prospective follow- up were included. Outcome was documented using a life charting technique. Current and previous exposure to AD and MS were assessed using a scale that provides a quantitative measure of exposure to psychotropic medications. Regression models were used to correct for possible confounders. RESULTS: Previous treatment with AD was an independent predictor of polarity changes (P < .001) and mixed symptoms (P = .01). In contrast, “years of exposure to MS” was an independent predictor of time spent asymptomatic (P = .019). The ratio between exposure to AD vs MS was associated with less weeks asymptomatic (P = .03), more mixed symptomatology (P = .019), and more polarity changes (P = .001). CONCLUSIONS: Antidepressant exposure was a major predictor of mood instability in the long-term outcome of BD. The ratio used of previous exposure to AD vs MS was associated with poor outcomes, suggesting that the harmful effect of AD may be additive and related to how much they are used.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193916
Strejilevich, Sergio; Martino, Diego Javier; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; et al.; Long-term worsening of bipolar disorder related with frequency of antidepressant exposure; Informa Healthcare; Annals Of Clinical Psychiatry; 23; 3; 8-2011; 186-192
1040-1237
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193916
identifier_str_mv Strejilevich, Sergio; Martino, Diego Javier; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; et al.; Long-term worsening of bipolar disorder related with frequency of antidepressant exposure; Informa Healthcare; Annals Of Clinical Psychiatry; 23; 3; 8-2011; 186-192
1040-1237
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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