A BK (Slo1) channel journey from molecule to physiology

Autores
Contreras, Gustavo F.; Castillo, Karen Noel; Enrique, Nicolás Jorge; Carrasquel Ursulaez, William; Castillo, Juan Pablo; Milesi, Verónica; Neely, Allan; Alvarez, Osvaldo; Ferreira, Gonzalo; Gonzáez, Carlos; Latorre, Ramón
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and nonneuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel α subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca2+ sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has been found to be relevant in many physiological processes. This review includes the hallmarks of BK channel biophysics and its physiological impact on specific cells and tissues, highlighting its relationship with auxiliary subunit expression.
Fil: Contreras, Gustavo F.. Universidad de Valparaíso; Chile
Fil: Castillo, Karen Noel. Universidad de Valparaíso; Chile
Fil: Enrique, Nicolás Jorge. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carrasquel Ursulaez, William. Universidad de Valparaíso; Chile
Fil: Castillo, Juan Pablo. Universidad de Valparaíso; Chile. Universidad de Chile; Chile
Fil: Milesi, Verónica. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Neely, Allan. Universidad de Valparaíso; Chile
Fil: Alvarez, Osvaldo. Universidad de Chile; Chile
Fil: Ferreira, Gonzalo. Universidad de la República; Uruguay
Fil: Gonzáez, Carlos. Universidad de Valparaíso; Chile
Fil: Latorre, Ramón. Universidad de Valparaíso; Chile
Materia
Bk Channels
Slo1
Auxiliary Subunits
Voltage Sensor
Intracellular Ca2+
Smooth Muscle
Diseases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23668
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23668
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A BK (Slo1) channel journey from molecule to physiologyContreras, Gustavo F.Castillo, Karen NoelEnrique, Nicolás JorgeCarrasquel Ursulaez, WilliamCastillo, Juan PabloMilesi, VerónicaNeely, AllanAlvarez, OsvaldoFerreira, GonzaloGonzáez, CarlosLatorre, RamónBk ChannelsSlo1Auxiliary SubunitsVoltage SensorIntracellular Ca2+Smooth MuscleDiseaseshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and nonneuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel α subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca2+ sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has been found to be relevant in many physiological processes. This review includes the hallmarks of BK channel biophysics and its physiological impact on specific cells and tissues, highlighting its relationship with auxiliary subunit expression.Fil: Contreras, Gustavo F.. Universidad de Valparaíso; ChileFil: Castillo, Karen Noel. Universidad de Valparaíso; ChileFil: Enrique, Nicolás Jorge. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carrasquel Ursulaez, William. Universidad de Valparaíso; ChileFil: Castillo, Juan Pablo. Universidad de Valparaíso; Chile. Universidad de Chile; ChileFil: Milesi, Verónica. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Neely, Allan. Universidad de Valparaíso; ChileFil: Alvarez, Osvaldo. Universidad de Chile; ChileFil: Ferreira, Gonzalo. Universidad de la República; UruguayFil: Gonzáez, Carlos. Universidad de Valparaíso; ChileFil: Latorre, Ramón. Universidad de Valparaíso; ChileTaylor & Francis2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23668Contreras, Gustavo F.; Castillo, Karen Noel; Enrique, Nicolás Jorge; Carrasquel Ursulaez, William; Castillo, Juan Pablo; et al.; A BK (Slo1) channel journey from molecule to physiology; Taylor & Francis; Channels; 7; 6; 9-2013; 442-4581933-6950CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/chan.26242info:eu-repo/semantics/altIdentifier/doi/10.4161/chan.26242info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:04Zoai:ri.conicet.gov.ar:11336/23668instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:04.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A BK (Slo1) channel journey from molecule to physiology
title A BK (Slo1) channel journey from molecule to physiology
spellingShingle A BK (Slo1) channel journey from molecule to physiology
Contreras, Gustavo F.
Bk Channels
Slo1
Auxiliary Subunits
Voltage Sensor
Intracellular Ca2+
Smooth Muscle
Diseases
title_short A BK (Slo1) channel journey from molecule to physiology
title_full A BK (Slo1) channel journey from molecule to physiology
title_fullStr A BK (Slo1) channel journey from molecule to physiology
title_full_unstemmed A BK (Slo1) channel journey from molecule to physiology
title_sort A BK (Slo1) channel journey from molecule to physiology
dc.creator.none.fl_str_mv Contreras, Gustavo F.
Castillo, Karen Noel
Enrique, Nicolás Jorge
Carrasquel Ursulaez, William
Castillo, Juan Pablo
Milesi, Verónica
Neely, Allan
Alvarez, Osvaldo
Ferreira, Gonzalo
Gonzáez, Carlos
Latorre, Ramón
author Contreras, Gustavo F.
author_facet Contreras, Gustavo F.
Castillo, Karen Noel
Enrique, Nicolás Jorge
Carrasquel Ursulaez, William
Castillo, Juan Pablo
Milesi, Verónica
Neely, Allan
Alvarez, Osvaldo
Ferreira, Gonzalo
Gonzáez, Carlos
Latorre, Ramón
author_role author
author2 Castillo, Karen Noel
Enrique, Nicolás Jorge
Carrasquel Ursulaez, William
Castillo, Juan Pablo
Milesi, Verónica
Neely, Allan
Alvarez, Osvaldo
Ferreira, Gonzalo
Gonzáez, Carlos
Latorre, Ramón
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bk Channels
Slo1
Auxiliary Subunits
Voltage Sensor
Intracellular Ca2+
Smooth Muscle
Diseases
topic Bk Channels
Slo1
Auxiliary Subunits
Voltage Sensor
Intracellular Ca2+
Smooth Muscle
Diseases
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and nonneuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel α subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca2+ sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has been found to be relevant in many physiological processes. This review includes the hallmarks of BK channel biophysics and its physiological impact on specific cells and tissues, highlighting its relationship with auxiliary subunit expression.
Fil: Contreras, Gustavo F.. Universidad de Valparaíso; Chile
Fil: Castillo, Karen Noel. Universidad de Valparaíso; Chile
Fil: Enrique, Nicolás Jorge. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carrasquel Ursulaez, William. Universidad de Valparaíso; Chile
Fil: Castillo, Juan Pablo. Universidad de Valparaíso; Chile. Universidad de Chile; Chile
Fil: Milesi, Verónica. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Neely, Allan. Universidad de Valparaíso; Chile
Fil: Alvarez, Osvaldo. Universidad de Chile; Chile
Fil: Ferreira, Gonzalo. Universidad de la República; Uruguay
Fil: Gonzáez, Carlos. Universidad de Valparaíso; Chile
Fil: Latorre, Ramón. Universidad de Valparaíso; Chile
description Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and nonneuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel α subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca2+ sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has been found to be relevant in many physiological processes. This review includes the hallmarks of BK channel biophysics and its physiological impact on specific cells and tissues, highlighting its relationship with auxiliary subunit expression.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23668
Contreras, Gustavo F.; Castillo, Karen Noel; Enrique, Nicolás Jorge; Carrasquel Ursulaez, William; Castillo, Juan Pablo; et al.; A BK (Slo1) channel journey from molecule to physiology; Taylor & Francis; Channels; 7; 6; 9-2013; 442-458
1933-6950
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23668
identifier_str_mv Contreras, Gustavo F.; Castillo, Karen Noel; Enrique, Nicolás Jorge; Carrasquel Ursulaez, William; Castillo, Juan Pablo; et al.; A BK (Slo1) channel journey from molecule to physiology; Taylor & Francis; Channels; 7; 6; 9-2013; 442-458
1933-6950
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/chan.26242
info:eu-repo/semantics/altIdentifier/doi/10.4161/chan.26242
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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