Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations

Autores
del Gaudio, Micaela Paula; Santi, María Daniela; Cabrera, Jose Luis; Peralta, Mariana Andrea; Ortega, María Gabriela
Año de publicación
2020
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Dalea L. (Fabaceae) includes species used in traditional medicine. Prenylflavonoids from Dalea, such as 2’,4’-dihydroxy-5’-(1’’’,1’’’-dimethylallyl)-8-prenylpinocembrin (8PP) present antioxidant,antityrosinase, and antifungal activities. This work aimed to investigate the chemical and biological properties of Dalea leporina, a species without any chemical or biological study, and to compare it with D. boliviana and D. pazensis.Hydro-alcoholic extracts from roots of the three species were obtained and their antioxidant,antityrosinase, antifungal, and cytotoxicity activities were evaluated, together with total phenols and flavonoids quantification and evaluation of relative content of 8PP in the threeextracts.D. boliviana presented the highest polyphenolics and flavonoid contents and antioxidant properties.8PP was determined in the three Dalea extracts, with the highest content in D. pazensis, which showed relevant tyrosinase inhibition. D. leporina showed important antifungal activity againstazole-resistant Candida albicans. Dalea extracts showed important bioactivities and high maximum non-cytotoxic concentrations, and are potential sources of new phyto-bioactive ingredients.
Fil: del Gaudio, Micaela Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Santi, María Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Peralta, Mariana Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Materia
Phyto-bioactive ingredients
Prenylflavanone
Antityrosinase
Antioxidant
Antifungal
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150516
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/150516
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluationsdel Gaudio, Micaela PaulaSanti, María DanielaCabrera, Jose LuisPeralta, Mariana AndreaOrtega, María GabrielaPhyto-bioactive ingredientsPrenylflavanoneAntityrosinaseAntioxidantAntifungalhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dalea L. (Fabaceae) includes species used in traditional medicine. Prenylflavonoids from Dalea, such as 2’,4’-dihydroxy-5’-(1’’’,1’’’-dimethylallyl)-8-prenylpinocembrin (8PP) present antioxidant,antityrosinase, and antifungal activities. This work aimed to investigate the chemical and biological properties of Dalea leporina, a species without any chemical or biological study, and to compare it with D. boliviana and D. pazensis.Hydro-alcoholic extracts from roots of the three species were obtained and their antioxidant,antityrosinase, antifungal, and cytotoxicity activities were evaluated, together with total phenols and flavonoids quantification and evaluation of relative content of 8PP in the threeextracts.D. boliviana presented the highest polyphenolics and flavonoid contents and antioxidant properties.8PP was determined in the three Dalea extracts, with the highest content in D. pazensis, which showed relevant tyrosinase inhibition. D. leporina showed important antifungal activity againstazole-resistant Candida albicans. Dalea extracts showed important bioactivities and high maximum non-cytotoxic concentrations, and are potential sources of new phyto-bioactive ingredients.Fil: del Gaudio, Micaela Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Santi, María Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Peralta, Mariana Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaAtena EditoraDias da Silva, Clécio Danilo2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150516del Gaudio, Micaela Paula; Santi, María Daniela; Cabrera, Jose Luis; Peralta, Mariana Andrea; Ortega, María Gabriela; Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations; Atena Editora; 2020; 130-143978-65-5706-438-2CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.atenaeditora.com.br/post-artigo/40279info:eu-repo/semantics/altIdentifier/doi/10.22533/at.ed.38220021012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:01Zoai:ri.conicet.gov.ar:11336/150516instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:01.341CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
title Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
spellingShingle Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
del Gaudio, Micaela Paula
Phyto-bioactive ingredients
Prenylflavanone
Antityrosinase
Antioxidant
Antifungal
title_short Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
title_full Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
title_fullStr Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
title_full_unstemmed Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
title_sort Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations
dc.creator.none.fl_str_mv del Gaudio, Micaela Paula
Santi, María Daniela
Cabrera, Jose Luis
Peralta, Mariana Andrea
Ortega, María Gabriela
author del Gaudio, Micaela Paula
author_facet del Gaudio, Micaela Paula
Santi, María Daniela
Cabrera, Jose Luis
Peralta, Mariana Andrea
Ortega, María Gabriela
author_role author
author2 Santi, María Daniela
Cabrera, Jose Luis
Peralta, Mariana Andrea
Ortega, María Gabriela
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dias da Silva, Clécio Danilo
dc.subject.none.fl_str_mv Phyto-bioactive ingredients
Prenylflavanone
Antityrosinase
Antioxidant
Antifungal
topic Phyto-bioactive ingredients
Prenylflavanone
Antityrosinase
Antioxidant
Antifungal
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Dalea L. (Fabaceae) includes species used in traditional medicine. Prenylflavonoids from Dalea, such as 2’,4’-dihydroxy-5’-(1’’’,1’’’-dimethylallyl)-8-prenylpinocembrin (8PP) present antioxidant,antityrosinase, and antifungal activities. This work aimed to investigate the chemical and biological properties of Dalea leporina, a species without any chemical or biological study, and to compare it with D. boliviana and D. pazensis.Hydro-alcoholic extracts from roots of the three species were obtained and their antioxidant,antityrosinase, antifungal, and cytotoxicity activities were evaluated, together with total phenols and flavonoids quantification and evaluation of relative content of 8PP in the threeextracts.D. boliviana presented the highest polyphenolics and flavonoid contents and antioxidant properties.8PP was determined in the three Dalea extracts, with the highest content in D. pazensis, which showed relevant tyrosinase inhibition. D. leporina showed important antifungal activity againstazole-resistant Candida albicans. Dalea extracts showed important bioactivities and high maximum non-cytotoxic concentrations, and are potential sources of new phyto-bioactive ingredients.
Fil: del Gaudio, Micaela Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Santi, María Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Peralta, Mariana Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
description Dalea L. (Fabaceae) includes species used in traditional medicine. Prenylflavonoids from Dalea, such as 2’,4’-dihydroxy-5’-(1’’’,1’’’-dimethylallyl)-8-prenylpinocembrin (8PP) present antioxidant,antityrosinase, and antifungal activities. This work aimed to investigate the chemical and biological properties of Dalea leporina, a species without any chemical or biological study, and to compare it with D. boliviana and D. pazensis.Hydro-alcoholic extracts from roots of the three species were obtained and their antioxidant,antityrosinase, antifungal, and cytotoxicity activities were evaluated, together with total phenols and flavonoids quantification and evaluation of relative content of 8PP in the threeextracts.D. boliviana presented the highest polyphenolics and flavonoid contents and antioxidant properties.8PP was determined in the three Dalea extracts, with the highest content in D. pazensis, which showed relevant tyrosinase inhibition. D. leporina showed important antifungal activity againstazole-resistant Candida albicans. Dalea extracts showed important bioactivities and high maximum non-cytotoxic concentrations, and are potential sources of new phyto-bioactive ingredients.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150516
del Gaudio, Micaela Paula; Santi, María Daniela; Cabrera, Jose Luis; Peralta, Mariana Andrea; Ortega, María Gabriela; Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations; Atena Editora; 2020; 130-143
978-65-5706-438-2
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150516
identifier_str_mv del Gaudio, Micaela Paula; Santi, María Daniela; Cabrera, Jose Luis; Peralta, Mariana Andrea; Ortega, María Gabriela; Dalea extracts as potential ingredients for phyto-formulations: Antioxidant, antityrosinase, antifungal and cytotoxicity in vitro evaluations; Atena Editora; 2020; 130-143
978-65-5706-438-2
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.atenaeditora.com.br/post-artigo/40279
info:eu-repo/semantics/altIdentifier/doi/10.22533/at.ed.38220021012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Atena Editora
publisher.none.fl_str_mv Atena Editora
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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