Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline

Autores
Martínez, S. M.; Simonella, Lucio Esteban; Hansen, C.; Rivolta, S.; Cancela, Liliana Marina; Virgolini, Miriam Beatriz
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring d-aminolevulinic acid dehydratase (d-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 + 0.30 mg/dl. Enzymatic d-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased d-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.
Fil: Martínez, S. M.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Simonella, Lucio Esteban. Universidad Nacional de Cordoba. Facultad de Ciencias Exactas Fisicas y Naturales. Centro de Investigaciones Geoquímicas y Procesos de Superficie; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hansen, C.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Rivolta, S.. Provincia de Córdoba. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Materia
Lead Exposure
Children
Biomarkers
Low Socio-Economic Status
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25463
Acceder
id CONICETDig_72c91da3d86e885a532131bba8676e97
oai_identifier_str oai:ri.conicet.gov.ar:11336/25463
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasolineMartínez, S. M.Simonella, Lucio EstebanHansen, C.Rivolta, S.Cancela, Liliana MarinaVirgolini, Miriam BeatrizLead ExposureChildrenBiomarkersLow Socio-Economic Statushttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring d-aminolevulinic acid dehydratase (d-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 + 0.30 mg/dl. Enzymatic d-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased d-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.Fil: Martínez, S. M.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaFil: Simonella, Lucio Esteban. Universidad Nacional de Cordoba. Facultad de Ciencias Exactas Fisicas y Naturales. Centro de Investigaciones Geoquímicas y Procesos de Superficie; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hansen, C.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaFil: Rivolta, S.. Provincia de Córdoba. Hospital de Niños de la Santísima Trinidad; ArgentinaFil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaFil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaSage Publications Ltd2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25463Martínez, S. M.; Simonella, Lucio Esteban; Hansen, C.; Rivolta, S.; Cancela, Liliana Marina; et al.; Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline; Sage Publications Ltd; Human and Experimental Toxicoloxy; 32; 5; 5-2013; 449-4630960-3271CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/0960327112454893info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0960327112454893info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:51:08Zoai:ri.conicet.gov.ar:11336/25463instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:51:08.93CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
title Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
spellingShingle Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
Martínez, S. M.
Lead Exposure
Children
Biomarkers
Low Socio-Economic Status
title_short Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
title_full Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
title_fullStr Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
title_full_unstemmed Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
title_sort Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
dc.creator.none.fl_str_mv Martínez, S. M.
Simonella, Lucio Esteban
Hansen, C.
Rivolta, S.
Cancela, Liliana Marina
Virgolini, Miriam Beatriz
author Martínez, S. M.
author_facet Martínez, S. M.
Simonella, Lucio Esteban
Hansen, C.
Rivolta, S.
Cancela, Liliana Marina
Virgolini, Miriam Beatriz
author_role author
author2 Simonella, Lucio Esteban
Hansen, C.
Rivolta, S.
Cancela, Liliana Marina
Virgolini, Miriam Beatriz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lead Exposure
Children
Biomarkers
Low Socio-Economic Status
topic Lead Exposure
Children
Biomarkers
Low Socio-Economic Status
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring d-aminolevulinic acid dehydratase (d-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 + 0.30 mg/dl. Enzymatic d-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased d-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.
Fil: Martínez, S. M.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Simonella, Lucio Esteban. Universidad Nacional de Cordoba. Facultad de Ciencias Exactas Fisicas y Naturales. Centro de Investigaciones Geoquímicas y Procesos de Superficie; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hansen, C.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Rivolta, S.. Provincia de Córdoba. Hospital de Niños de la Santísima Trinidad; Argentina
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
description Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring d-aminolevulinic acid dehydratase (d-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 + 0.30 mg/dl. Enzymatic d-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased d-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25463
Martínez, S. M.; Simonella, Lucio Esteban; Hansen, C.; Rivolta, S.; Cancela, Liliana Marina; et al.; Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline; Sage Publications Ltd; Human and Experimental Toxicoloxy; 32; 5; 5-2013; 449-463
0960-3271
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25463
identifier_str_mv Martínez, S. M.; Simonella, Lucio Esteban; Hansen, C.; Rivolta, S.; Cancela, Liliana Marina; et al.; Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline; Sage Publications Ltd; Human and Experimental Toxicoloxy; 32; 5; 5-2013; 449-463
0960-3271
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/0960327112454893
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0960327112454893
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sage Publications Ltd
publisher.none.fl_str_mv Sage Publications Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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