Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models

Autores
Garcia Lazaro, Rocio Soledad; Caligiuri, Lorena Gisel; Lorenzo Pérez, Norailys; Lamdan, Humberto; Alonso, Daniel Fernando; Farina, Hernán Gabriel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.
Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes; Argentina
Fil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes; Argentina
Fil: Lamdan, Humberto. Universidad Nacional de Quilmes; Argentina
Fil: Alonso, Daniel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BREAST CANCER
METASTASIS
POLYPHENOLS
TUMOR PROGRESSION
YERBA MATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/220091
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/220091
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer ModelsGarcia Lazaro, Rocio SoledadCaligiuri, Lorena GiselLorenzo Pérez, NorailysLamdan, HumbertoAlonso, Daniel FernandoFarina, Hernán GabrielBREAST CANCERMETASTASISPOLYPHENOLSTUMOR PROGRESSIONYERBA MATEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes; ArgentinaFil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes; ArgentinaFil: Lamdan, Humberto. Universidad Nacional de Quilmes; ArgentinaFil: Alonso, Daniel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Media2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/220091Garcia Lazaro, Rocio Soledad; Caligiuri, Lorena Gisel; Lorenzo Pérez, Norailys; Lamdan, Humberto; Alonso, Daniel Fernando; et al.; Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models; Frontiers Media; Frontiers in Pharmacology; 12; 11-2021; 1-141663-9812CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2021.750197info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:45:31Zoai:ri.conicet.gov.ar:11336/220091instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:45:31.912CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
spellingShingle Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
Garcia Lazaro, Rocio Soledad
BREAST CANCER
METASTASIS
POLYPHENOLS
TUMOR PROGRESSION
YERBA MATE
title_short Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_full Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_fullStr Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_full_unstemmed Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
title_sort Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models
dc.creator.none.fl_str_mv Garcia Lazaro, Rocio Soledad
Caligiuri, Lorena Gisel
Lorenzo Pérez, Norailys
Lamdan, Humberto
Alonso, Daniel Fernando
Farina, Hernán Gabriel
author Garcia Lazaro, Rocio Soledad
author_facet Garcia Lazaro, Rocio Soledad
Caligiuri, Lorena Gisel
Lorenzo Pérez, Norailys
Lamdan, Humberto
Alonso, Daniel Fernando
Farina, Hernán Gabriel
author_role author
author2 Caligiuri, Lorena Gisel
Lorenzo Pérez, Norailys
Lamdan, Humberto
Alonso, Daniel Fernando
Farina, Hernán Gabriel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BREAST CANCER
METASTASIS
POLYPHENOLS
TUMOR PROGRESSION
YERBA MATE
topic BREAST CANCER
METASTASIS
POLYPHENOLS
TUMOR PROGRESSION
YERBA MATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.
Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes; Argentina
Fil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes; Argentina
Fil: Lamdan, Humberto. Universidad Nacional de Quilmes; Argentina
Fil: Alonso, Daniel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Breast cancer (BC) is the most frequent cancer in women and tumor metastasis is a major cause of cancer-related deaths. Our aim was to evaluate anti-metastatic properties of yerba mate extract (YMe) in BC models. 4T1, F3II, MCF-7, and MDA-MB231 cell lines were used to perform in vitro assays. The F3II syngeneic mammary carcinoma model in BALB/c mice was used to evaluate tumor progression, BC metastasis and survival. Cells were inoculated subcutaneously into the flank for the heterotopic model and into the mammary fat pad for the orthotopic model. YMe was administered p.o. in a dose of 1.6 g/kg/day. In vitro YMe inhibited cell proliferation and reduced tumor cell adhesion, migration and invasion. These biological effects were cell-line dependent. In vivo YMe reduced tumor metastasis and increased mice survival in both models. Our preclinical results suggest that YMe could modulate tumor progression and metastasis in BC models.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/220091
Garcia Lazaro, Rocio Soledad; Caligiuri, Lorena Gisel; Lorenzo Pérez, Norailys; Lamdan, Humberto; Alonso, Daniel Fernando; et al.; Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models; Frontiers Media; Frontiers in Pharmacology; 12; 11-2021; 1-14
1663-9812
CONICET Digital
CONICET
url http://hdl.handle.net/11336/220091
identifier_str_mv Garcia Lazaro, Rocio Soledad; Caligiuri, Lorena Gisel; Lorenzo Pérez, Norailys; Lamdan, Humberto; Alonso, Daniel Fernando; et al.; Yerba Mate Modulates Tumor Cells Functions Involved in Metastasis in Breast Cancer Models; Frontiers Media; Frontiers in Pharmacology; 12; 11-2021; 1-14
1663-9812
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2021.750197
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083554999533568
score 13.22299

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