Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions

Autores
Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; Sarrio L; Stu,r Mabel; Mardegan Issa Joao P,; Fonseca S; Feldman, Sara
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired.
Fil: Alvarez, José Luis. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Francioni, Nicolas. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Operti, Clara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Orellana ,Marcelo F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Santiago, Octavio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Sarrio L. No especifíca;
Fil: Stu,r Mabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Mardegan Issa Joao P,. School Of Dentistry Of Ribeirão Preto, University Of Sã; Brasil
Fil: Fonseca S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CARTILAGE
REGENERATION
HYALURONIC ACID
OSTEOCHONDRAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243649

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral LesionsAlvarez, José LuisFrancioni, NicolasOperti, ClaraOrellana ,Marcelo F.Santiago, OctavioSarrio LStu,r MabelMardegan Issa Joao P,Fonseca SFeldman, SaraCARTILAGEREGENERATIONHYALURONIC ACIDOSTEOCHONDRALhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired.Fil: Alvarez, José Luis. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Francioni, Nicolas. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Operti, Clara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Orellana ,Marcelo F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Santiago, Octavio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Sarrio L. No especifíca;Fil: Stu,r Mabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Mardegan Issa Joao P,. School Of Dentistry Of Ribeirão Preto, University Of Sã; BrasilFil: Fonseca S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAsociación Argentina de Ortopedia y Traumatología2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243649Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; et al.; Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions; Asociación Argentina de Ortopedia y Traumatología; Revista de la Asociacion Argentina de Ortopedia y Traumatologia; 89; 8-2024; 374-3841852-7434CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.15417/issn.1852-7434.2024.89.4.1871info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:18Zoai:ri.conicet.gov.ar:11336/243649instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:19.054CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
title Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
spellingShingle Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
Alvarez, José Luis
CARTILAGE
REGENERATION
HYALURONIC ACID
OSTEOCHONDRAL
title_short Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
title_full Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
title_fullStr Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
title_full_unstemmed Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
title_sort Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
dc.creator.none.fl_str_mv Alvarez, José Luis
Francioni, Nicolas
Operti, Clara
Orellana ,Marcelo F.
Santiago, Octavio
Sarrio L
Stu,r Mabel
Mardegan Issa Joao P,
Fonseca S
Feldman, Sara
author Alvarez, José Luis
author_facet Alvarez, José Luis
Francioni, Nicolas
Operti, Clara
Orellana ,Marcelo F.
Santiago, Octavio
Sarrio L
Stu,r Mabel
Mardegan Issa Joao P,
Fonseca S
Feldman, Sara
author_role author
author2 Francioni, Nicolas
Operti, Clara
Orellana ,Marcelo F.
Santiago, Octavio
Sarrio L
Stu,r Mabel
Mardegan Issa Joao P,
Fonseca S
Feldman, Sara
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CARTILAGE
REGENERATION
HYALURONIC ACID
OSTEOCHONDRAL
topic CARTILAGE
REGENERATION
HYALURONIC ACID
OSTEOCHONDRAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired.
Fil: Alvarez, José Luis. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Francioni, Nicolas. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Operti, Clara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Orellana ,Marcelo F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Santiago, Octavio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Sarrio L. No especifíca;
Fil: Stu,r Mabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Mardegan Issa Joao P,. School Of Dentistry Of Ribeirão Preto, University Of Sã; Brasil
Fil: Fonseca S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired.
publishDate 2024
dc.date.none.fl_str_mv 2024-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243649
Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; et al.; Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions; Asociación Argentina de Ortopedia y Traumatología; Revista de la Asociacion Argentina de Ortopedia y Traumatologia; 89; 8-2024; 374-384
1852-7434
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243649
identifier_str_mv Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; et al.; Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions; Asociación Argentina de Ortopedia y Traumatología; Revista de la Asociacion Argentina de Ortopedia y Traumatologia; 89; 8-2024; 374-384
1852-7434
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.15417/issn.1852-7434.2024.89.4.1871
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Ortopedia y Traumatología
publisher.none.fl_str_mv Asociación Argentina de Ortopedia y Traumatología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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