Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions
- Autores
- Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; Sarrio L; Stu,r Mabel; Mardegan Issa Joao P,; Fonseca S; Feldman, Sara
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired.
Fil: Alvarez, José Luis. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Francioni, Nicolas. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Operti, Clara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Orellana ,Marcelo F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Santiago, Octavio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Sarrio L. No especifíca;
Fil: Stu,r Mabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Mardegan Issa Joao P,. School Of Dentistry Of Ribeirão Preto, University Of Sã; Brasil
Fil: Fonseca S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
CARTILAGE
REGENERATION
HYALURONIC ACID
OSTEOCHONDRAL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/243649
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Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral LesionsAlvarez, José LuisFrancioni, NicolasOperti, ClaraOrellana ,Marcelo F.Santiago, OctavioSarrio LStu,r MabelMardegan Issa Joao P,Fonseca SFeldman, SaraCARTILAGEREGENERATIONHYALURONIC ACIDOSTEOCHONDRALhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired.Fil: Alvarez, José Luis. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Francioni, Nicolas. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Operti, Clara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Orellana ,Marcelo F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Santiago, Octavio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Sarrio L. No especifíca;Fil: Stu,r Mabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Mardegan Issa Joao P,. School Of Dentistry Of Ribeirão Preto, University Of Sã; BrasilFil: Fonseca S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAsociación Argentina de Ortopedia y Traumatología2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243649Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; et al.; Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions; Asociación Argentina de Ortopedia y Traumatología; Revista de la Asociacion Argentina de Ortopedia y Traumatologia; 89; 8-2024; 374-3841852-7434CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.15417/issn.1852-7434.2024.89.4.1871info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:18Zoai:ri.conicet.gov.ar:11336/243649instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:19.054CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
title |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
spellingShingle |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions Alvarez, José Luis CARTILAGE REGENERATION HYALURONIC ACID OSTEOCHONDRAL |
title_short |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
title_full |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
title_fullStr |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
title_full_unstemmed |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
title_sort |
Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions |
dc.creator.none.fl_str_mv |
Alvarez, José Luis Francioni, Nicolas Operti, Clara Orellana ,Marcelo F. Santiago, Octavio Sarrio L Stu,r Mabel Mardegan Issa Joao P, Fonseca S Feldman, Sara |
author |
Alvarez, José Luis |
author_facet |
Alvarez, José Luis Francioni, Nicolas Operti, Clara Orellana ,Marcelo F. Santiago, Octavio Sarrio L Stu,r Mabel Mardegan Issa Joao P, Fonseca S Feldman, Sara |
author_role |
author |
author2 |
Francioni, Nicolas Operti, Clara Orellana ,Marcelo F. Santiago, Octavio Sarrio L Stu,r Mabel Mardegan Issa Joao P, Fonseca S Feldman, Sara |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
CARTILAGE REGENERATION HYALURONIC ACID OSTEOCHONDRAL |
topic |
CARTILAGE REGENERATION HYALURONIC ACID OSTEOCHONDRAL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired. Fil: Alvarez, José Luis. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Francioni, Nicolas. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Operti, Clara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Orellana ,Marcelo F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Santiago, Octavio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Sarrio L. No especifíca; Fil: Stu,r Mabel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Mardegan Issa Joao P,. School Of Dentistry Of Ribeirão Preto, University Of Sã; Brasil Fil: Fonseca S. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Feldman, Sara. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Objective: To demonstrate whether treatment with biphasic cross-linked hyaluronic acid in osteochondral lesions promotes the regeneration of cartilage tissue. Materials and Methods: Fifteen adult female rabbits were randomly assigned to three groups. G1 was the control group, whereas G2 and G3 underwent surgery to treat an osteochondral injury in the right knee (4mm diameter, 5mm depth). G3 received treatment with 0.2 ml of hyaluronic acid intrarticularly after surgery. Clinical, biochemical, histopathological controls and imaging studies were performed. Results: Clinically, G3 exhibited less pain on palpation than G2 after 45 days. In G3, almost all samples showed evidence of cartilage tissue regeneration at the injury site, with neither bone edema or considerable joint effusion detected on MRI. The histological tests of G3 samples revealed an increase in the extracellular matrix of cartilaginous tissue when compared to G2, with hypercellularity caused by chondrocytes that formed axial and coronal isogenic groups. Conclusions: This study pides evidence that treatment with biphasic crovross-linked hyaluronic acid in experimental units of rabbits with osteochondral injuries did not cause pain in the early stages of the injury. In turn, imaging and histopathological studies revealed that the injured tissue had been repaired. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/243649 Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; et al.; Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions; Asociación Argentina de Ortopedia y Traumatología; Revista de la Asociacion Argentina de Ortopedia y Traumatologia; 89; 8-2024; 374-384 1852-7434 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/243649 |
identifier_str_mv |
Alvarez, José Luis; Francioni, Nicolas; Operti, Clara; Orellana ,Marcelo F.; Santiago, Octavio; et al.; Regenerative Medicine: Effect of Treatment with Biphasic Cross-Linked Hyaluronic Acid in Osteochondral Lesions; Asociación Argentina de Ortopedia y Traumatología; Revista de la Asociacion Argentina de Ortopedia y Traumatologia; 89; 8-2024; 374-384 1852-7434 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.15417/issn.1852-7434.2024.89.4.1871 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Asociación Argentina de Ortopedia y Traumatología |
publisher.none.fl_str_mv |
Asociación Argentina de Ortopedia y Traumatología |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |