Alterations in affective behavior during the time course of alcohol hangover

Autores
Karadayian, Analia Graciela; Busso, María Julia; Feleder, Carlos Alberto; Cutrera, Rodolfo Angel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alcohol hangover is a temporary state described as the unpleasant next-day effects after binge-like drinking. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. Affective behavior is impaired during the acute phase of alcohol intoxication; however, no reports indicate if similar effects are observed during withdrawal. The aim of this work was to study the time-extension and possible fluctuations in affective behavior during a hangover episode. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8. g/kg BW) (hangover group). Anxiety, fear-related behavior and despair phenotype were evaluated at a basal point (ZT0) and every 2. h up to 20. h after blood alcohol levels were close to zero (hangover onset). Also, anhedonia signs and pain perception disabilities were studied. Mice exhibited an increase in anxiety-like behavior during 4. h and 14. h after hangover onset when evaluated by the elevated-plus maze and open field test respectively (p<. 0.05). Fear-related behavior was detected in hangover animals by the increase of freezing and decrease of line crossings and rearing frequency during 16. h after hangover onset (p<. 0.001). Depression signs were found in hangover mice during 14. h (p<. 0.05). Hangover mice showed a significant decrease in pain perception when tested by tail immersion test at the beginning of hangover (p<. 0.05). Our findings demonstrate a time-extension between 14 and 16. h for hangover affective impairments. This study shows the long lasting effects of hangover over the phase of ethanol intoxication. © 2013 Elsevier B.V.
Fil: Karadayian, Analia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Busso, María Julia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Feleder, Carlos Alberto. The Albany Medical College; Estados Unidos
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Materia
ALCOHOL HANGOVER
ANHEDONIA
ANXIETY-LIKE BEHAVIOR
DEPRESSION
NOCICEPTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84743
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Alterations in affective behavior during the time course of alcohol hangoverKaradayian, Analia GracielaBusso, María JuliaFeleder, Carlos AlbertoCutrera, Rodolfo AngelALCOHOL HANGOVERANHEDONIAANXIETY-LIKE BEHAVIORDEPRESSIONNOCICEPTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Alcohol hangover is a temporary state described as the unpleasant next-day effects after binge-like drinking. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. Affective behavior is impaired during the acute phase of alcohol intoxication; however, no reports indicate if similar effects are observed during withdrawal. The aim of this work was to study the time-extension and possible fluctuations in affective behavior during a hangover episode. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8. g/kg BW) (hangover group). Anxiety, fear-related behavior and despair phenotype were evaluated at a basal point (ZT0) and every 2. h up to 20. h after blood alcohol levels were close to zero (hangover onset). Also, anhedonia signs and pain perception disabilities were studied. Mice exhibited an increase in anxiety-like behavior during 4. h and 14. h after hangover onset when evaluated by the elevated-plus maze and open field test respectively (p<. 0.05). Fear-related behavior was detected in hangover animals by the increase of freezing and decrease of line crossings and rearing frequency during 16. h after hangover onset (p<. 0.001). Depression signs were found in hangover mice during 14. h (p<. 0.05). Hangover mice showed a significant decrease in pain perception when tested by tail immersion test at the beginning of hangover (p<. 0.05). Our findings demonstrate a time-extension between 14 and 16. h for hangover affective impairments. This study shows the long lasting effects of hangover over the phase of ethanol intoxication. © 2013 Elsevier B.V.Fil: Karadayian, Analia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Busso, María Julia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Feleder, Carlos Alberto. The Albany Medical College; Estados UnidosFil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaElsevier Science2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84743Karadayian, Analia Graciela; Busso, María Julia; Feleder, Carlos Alberto; Cutrera, Rodolfo Angel; Alterations in affective behavior during the time course of alcohol hangover; Elsevier Science; Behavioural Brain Research; 253; 9-2013; 128-1380166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2013.07.011info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432813004105info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:10Zoai:ri.conicet.gov.ar:11336/84743instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:11.222CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alterations in affective behavior during the time course of alcohol hangover
title Alterations in affective behavior during the time course of alcohol hangover
spellingShingle Alterations in affective behavior during the time course of alcohol hangover
Karadayian, Analia Graciela
ALCOHOL HANGOVER
ANHEDONIA
ANXIETY-LIKE BEHAVIOR
DEPRESSION
NOCICEPTION
title_short Alterations in affective behavior during the time course of alcohol hangover
title_full Alterations in affective behavior during the time course of alcohol hangover
title_fullStr Alterations in affective behavior during the time course of alcohol hangover
title_full_unstemmed Alterations in affective behavior during the time course of alcohol hangover
title_sort Alterations in affective behavior during the time course of alcohol hangover
dc.creator.none.fl_str_mv Karadayian, Analia Graciela
Busso, María Julia
Feleder, Carlos Alberto
Cutrera, Rodolfo Angel
author Karadayian, Analia Graciela
author_facet Karadayian, Analia Graciela
Busso, María Julia
Feleder, Carlos Alberto
Cutrera, Rodolfo Angel
author_role author
author2 Busso, María Julia
Feleder, Carlos Alberto
Cutrera, Rodolfo Angel
author2_role author
author
author
dc.subject.none.fl_str_mv ALCOHOL HANGOVER
ANHEDONIA
ANXIETY-LIKE BEHAVIOR
DEPRESSION
NOCICEPTION
topic ALCOHOL HANGOVER
ANHEDONIA
ANXIETY-LIKE BEHAVIOR
DEPRESSION
NOCICEPTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Alcohol hangover is a temporary state described as the unpleasant next-day effects after binge-like drinking. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. Affective behavior is impaired during the acute phase of alcohol intoxication; however, no reports indicate if similar effects are observed during withdrawal. The aim of this work was to study the time-extension and possible fluctuations in affective behavior during a hangover episode. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8. g/kg BW) (hangover group). Anxiety, fear-related behavior and despair phenotype were evaluated at a basal point (ZT0) and every 2. h up to 20. h after blood alcohol levels were close to zero (hangover onset). Also, anhedonia signs and pain perception disabilities were studied. Mice exhibited an increase in anxiety-like behavior during 4. h and 14. h after hangover onset when evaluated by the elevated-plus maze and open field test respectively (p<. 0.05). Fear-related behavior was detected in hangover animals by the increase of freezing and decrease of line crossings and rearing frequency during 16. h after hangover onset (p<. 0.001). Depression signs were found in hangover mice during 14. h (p<. 0.05). Hangover mice showed a significant decrease in pain perception when tested by tail immersion test at the beginning of hangover (p<. 0.05). Our findings demonstrate a time-extension between 14 and 16. h for hangover affective impairments. This study shows the long lasting effects of hangover over the phase of ethanol intoxication. © 2013 Elsevier B.V.
Fil: Karadayian, Analia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Busso, María Julia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Feleder, Carlos Alberto. The Albany Medical College; Estados Unidos
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
description Alcohol hangover is a temporary state described as the unpleasant next-day effects after binge-like drinking. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. Affective behavior is impaired during the acute phase of alcohol intoxication; however, no reports indicate if similar effects are observed during withdrawal. The aim of this work was to study the time-extension and possible fluctuations in affective behavior during a hangover episode. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8. g/kg BW) (hangover group). Anxiety, fear-related behavior and despair phenotype were evaluated at a basal point (ZT0) and every 2. h up to 20. h after blood alcohol levels were close to zero (hangover onset). Also, anhedonia signs and pain perception disabilities were studied. Mice exhibited an increase in anxiety-like behavior during 4. h and 14. h after hangover onset when evaluated by the elevated-plus maze and open field test respectively (p<. 0.05). Fear-related behavior was detected in hangover animals by the increase of freezing and decrease of line crossings and rearing frequency during 16. h after hangover onset (p<. 0.001). Depression signs were found in hangover mice during 14. h (p<. 0.05). Hangover mice showed a significant decrease in pain perception when tested by tail immersion test at the beginning of hangover (p<. 0.05). Our findings demonstrate a time-extension between 14 and 16. h for hangover affective impairments. This study shows the long lasting effects of hangover over the phase of ethanol intoxication. © 2013 Elsevier B.V.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84743
Karadayian, Analia Graciela; Busso, María Julia; Feleder, Carlos Alberto; Cutrera, Rodolfo Angel; Alterations in affective behavior during the time course of alcohol hangover; Elsevier Science; Behavioural Brain Research; 253; 9-2013; 128-138
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84743
identifier_str_mv Karadayian, Analia Graciela; Busso, María Julia; Feleder, Carlos Alberto; Cutrera, Rodolfo Angel; Alterations in affective behavior during the time course of alcohol hangover; Elsevier Science; Behavioural Brain Research; 253; 9-2013; 128-138
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2013.07.011
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432813004105
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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