The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging

Autores
de Cavanagh, E. M. V.; Piotrkowski, Barbara; Fraga, César Guillermo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of improving health is intimately associated with preventing and delaying age-related diseases. Nutritional and pharmacological approaches aimed at retarding aging are uncovering mechanisms, whose definitive roles in cell and tissue physiology need to be defined. In this article we hypothesize that peroxisome proliferator activated receptor (PPAR)-modulation is a pivotal process that underlies the association between mitochondria and the renin-angiotensin system (RAS) in aging. This hypothesis is based on several lines of evidence suggesting that: a) mitochondrial function and oxidant production are active participants in the aging process; b) PPARs, by regulating mitochondrial function and uncoupling proteins (UCP), seem to play a major role in the age-retarding effects of caloric restriction; c) RAS inhibition delays the deleterious effects of aging and also upregulates PPARs; and d) a number of physiological and molecular events that occur in experimental caloric restriction, and experimental and clinical RAS inhibition, involve changes in mitochondrial functions.
Fil: de Cavanagh, E. M. V.. Universidad de Buenos Aires; Argentina
Fil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
ANGIOTENSIN
MITOCHONDRIA
OXIDATIVE DAMAGE
RESPIRATORY CHAIN
REVIEW
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/139547
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in agingde Cavanagh, E. M. V.Piotrkowski, BarbaraFraga, César GuillermoANGIOTENSINMITOCHONDRIAOXIDATIVE DAMAGERESPIRATORY CHAINREVIEWhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The objective of improving health is intimately associated with preventing and delaying age-related diseases. Nutritional and pharmacological approaches aimed at retarding aging are uncovering mechanisms, whose definitive roles in cell and tissue physiology need to be defined. In this article we hypothesize that peroxisome proliferator activated receptor (PPAR)-modulation is a pivotal process that underlies the association between mitochondria and the renin-angiotensin system (RAS) in aging. This hypothesis is based on several lines of evidence suggesting that: a) mitochondrial function and oxidant production are active participants in the aging process; b) PPARs, by regulating mitochondrial function and uncoupling proteins (UCP), seem to play a major role in the age-retarding effects of caloric restriction; c) RAS inhibition delays the deleterious effects of aging and also upregulates PPARs; and d) a number of physiological and molecular events that occur in experimental caloric restriction, and experimental and clinical RAS inhibition, involve changes in mitochondrial functions.Fil: de Cavanagh, E. M. V.. Universidad de Buenos Aires; ArgentinaFil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFrontiers in Bioscience2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139547de Cavanagh, E. M. V.; Piotrkowski, Barbara; Fraga, César Guillermo; The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging; Frontiers in Bioscience; Frontiers in Bioscience; 12; 3; 12-2007; 1049-10621093-9946CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2741/2125info:eu-repo/semantics/altIdentifier/url/https://fbscience.com/Landmark/articles/10.2741/2125info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:49Zoai:ri.conicet.gov.ar:11336/139547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:49.718CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
title The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
spellingShingle The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
de Cavanagh, E. M. V.
ANGIOTENSIN
MITOCHONDRIA
OXIDATIVE DAMAGE
RESPIRATORY CHAIN
REVIEW
title_short The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
title_full The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
title_fullStr The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
title_full_unstemmed The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
title_sort The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
dc.creator.none.fl_str_mv de Cavanagh, E. M. V.
Piotrkowski, Barbara
Fraga, César Guillermo
author de Cavanagh, E. M. V.
author_facet de Cavanagh, E. M. V.
Piotrkowski, Barbara
Fraga, César Guillermo
author_role author
author2 Piotrkowski, Barbara
Fraga, César Guillermo
author2_role author
author
dc.subject.none.fl_str_mv ANGIOTENSIN
MITOCHONDRIA
OXIDATIVE DAMAGE
RESPIRATORY CHAIN
REVIEW
topic ANGIOTENSIN
MITOCHONDRIA
OXIDATIVE DAMAGE
RESPIRATORY CHAIN
REVIEW
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The objective of improving health is intimately associated with preventing and delaying age-related diseases. Nutritional and pharmacological approaches aimed at retarding aging are uncovering mechanisms, whose definitive roles in cell and tissue physiology need to be defined. In this article we hypothesize that peroxisome proliferator activated receptor (PPAR)-modulation is a pivotal process that underlies the association between mitochondria and the renin-angiotensin system (RAS) in aging. This hypothesis is based on several lines of evidence suggesting that: a) mitochondrial function and oxidant production are active participants in the aging process; b) PPARs, by regulating mitochondrial function and uncoupling proteins (UCP), seem to play a major role in the age-retarding effects of caloric restriction; c) RAS inhibition delays the deleterious effects of aging and also upregulates PPARs; and d) a number of physiological and molecular events that occur in experimental caloric restriction, and experimental and clinical RAS inhibition, involve changes in mitochondrial functions.
Fil: de Cavanagh, E. M. V.. Universidad de Buenos Aires; Argentina
Fil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
description The objective of improving health is intimately associated with preventing and delaying age-related diseases. Nutritional and pharmacological approaches aimed at retarding aging are uncovering mechanisms, whose definitive roles in cell and tissue physiology need to be defined. In this article we hypothesize that peroxisome proliferator activated receptor (PPAR)-modulation is a pivotal process that underlies the association between mitochondria and the renin-angiotensin system (RAS) in aging. This hypothesis is based on several lines of evidence suggesting that: a) mitochondrial function and oxidant production are active participants in the aging process; b) PPARs, by regulating mitochondrial function and uncoupling proteins (UCP), seem to play a major role in the age-retarding effects of caloric restriction; c) RAS inhibition delays the deleterious effects of aging and also upregulates PPARs; and d) a number of physiological and molecular events that occur in experimental caloric restriction, and experimental and clinical RAS inhibition, involve changes in mitochondrial functions.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139547
de Cavanagh, E. M. V.; Piotrkowski, Barbara; Fraga, César Guillermo; The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging; Frontiers in Bioscience; Frontiers in Bioscience; 12; 3; 12-2007; 1049-1062
1093-9946
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139547
identifier_str_mv de Cavanagh, E. M. V.; Piotrkowski, Barbara; Fraga, César Guillermo; The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging; Frontiers in Bioscience; Frontiers in Bioscience; 12; 3; 12-2007; 1049-1062
1093-9946
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2741/2125
info:eu-repo/semantics/altIdentifier/url/https://fbscience.com/Landmark/articles/10.2741/2125
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience
publisher.none.fl_str_mv Frontiers in Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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