Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization

Autores
de Arruda Almeida, Kleber; de Queiroz, Alvaro Antonio Alencar; Higa, Olga Zazuco; Abraham, Gustavo Abel; San Román, Julio
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The most serious problems usually encountered in the field of implanted medical devices are the infectious morbidity as primary source of mortality. In this work, the synthesis and characterization of a macroporous iodine based sanitizer (iodophor), poly(caprolactone)-iodine, are presented. Characterization methods include nuclear magnetic resonance spectroscopy (1H NMR), gel permeation chromatography (GPC), nitrogen adsorption-desorption and scanning electron microscopy (SEM).  The in vitro cytotoxicity to CHO cells in the MTT assay and antimicrobial activities against Escherichia coli and Staphylococcus aureus were examined. The obtained macropore poly(caprolactone)-iodine structures had a rather narrow size distribution. PCL-I iodophor was non-cytotoxic to CHO cells in the MTT assay. Bactericidal activities of the PCL-I were assessed against Escherichia coli and Staphylococcus aureus. The tested PCL-I showed more antimicrobial activity against E. coli and was less active against S. aureus.
Fil: de Arruda Almeida, Kleber. Universidade Federal de Itajuba; Brasil
Fil: de Queiroz, Alvaro Antonio Alencar. Universidade Federal de Itajuba; Brasil
Fil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energéticas e Nucleares; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: San Román, Julio. Instituto de Ciencia y Tecnología de Polímeros; España
Materia
Antimicrobial activity
Poly( -caprolactone)
Biological activity
Iodophor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98893
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98893
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerizationde Arruda Almeida, Kleberde Queiroz, Alvaro Antonio AlencarHiga, Olga ZazucoAbraham, Gustavo AbelSan Román, JulioAntimicrobial activityPoly( -caprolactone)Biological activityIodophorhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The most serious problems usually encountered in the field of implanted medical devices are the infectious morbidity as primary source of mortality. In this work, the synthesis and characterization of a macroporous iodine based sanitizer (iodophor), poly(caprolactone)-iodine, are presented. Characterization methods include nuclear magnetic resonance spectroscopy (1H NMR), gel permeation chromatography (GPC), nitrogen adsorption-desorption and scanning electron microscopy (SEM).  The in vitro cytotoxicity to CHO cells in the MTT assay and antimicrobial activities against Escherichia coli and Staphylococcus aureus were examined. The obtained macropore poly(caprolactone)-iodine structures had a rather narrow size distribution. PCL-I iodophor was non-cytotoxic to CHO cells in the MTT assay. Bactericidal activities of the PCL-I were assessed against Escherichia coli and Staphylococcus aureus. The tested PCL-I showed more antimicrobial activity against E. coli and was less active against S. aureus.Fil: de Arruda Almeida, Kleber. Universidade Federal de Itajuba; BrasilFil: de Queiroz, Alvaro Antonio Alencar. Universidade Federal de Itajuba; BrasilFil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energéticas e Nucleares; BrasilFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: San Román, Julio. Instituto de Ciencia y Tecnología de Polímeros; EspañaWiley-liss, Div John Wiley & Sons Inc2004-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98893de Arruda Almeida, Kleber; de Queiroz, Alvaro Antonio Alencar; Higa, Olga Zazuco; Abraham, Gustavo Abel; San Román, Julio; Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 68A; 3; 3-2004; 473-4781549-3296CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.20085info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.20085info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:54Zoai:ri.conicet.gov.ar:11336/98893instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:54.3CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
title Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
spellingShingle Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
de Arruda Almeida, Kleber
Antimicrobial activity
Poly( -caprolactone)
Biological activity
Iodophor
title_short Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
title_full Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
title_fullStr Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
title_full_unstemmed Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
title_sort Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization
dc.creator.none.fl_str_mv de Arruda Almeida, Kleber
de Queiroz, Alvaro Antonio Alencar
Higa, Olga Zazuco
Abraham, Gustavo Abel
San Román, Julio
author de Arruda Almeida, Kleber
author_facet de Arruda Almeida, Kleber
de Queiroz, Alvaro Antonio Alencar
Higa, Olga Zazuco
Abraham, Gustavo Abel
San Román, Julio
author_role author
author2 de Queiroz, Alvaro Antonio Alencar
Higa, Olga Zazuco
Abraham, Gustavo Abel
San Román, Julio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antimicrobial activity
Poly( -caprolactone)
Biological activity
Iodophor
topic Antimicrobial activity
Poly( -caprolactone)
Biological activity
Iodophor
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The most serious problems usually encountered in the field of implanted medical devices are the infectious morbidity as primary source of mortality. In this work, the synthesis and characterization of a macroporous iodine based sanitizer (iodophor), poly(caprolactone)-iodine, are presented. Characterization methods include nuclear magnetic resonance spectroscopy (1H NMR), gel permeation chromatography (GPC), nitrogen adsorption-desorption and scanning electron microscopy (SEM).  The in vitro cytotoxicity to CHO cells in the MTT assay and antimicrobial activities against Escherichia coli and Staphylococcus aureus were examined. The obtained macropore poly(caprolactone)-iodine structures had a rather narrow size distribution. PCL-I iodophor was non-cytotoxic to CHO cells in the MTT assay. Bactericidal activities of the PCL-I were assessed against Escherichia coli and Staphylococcus aureus. The tested PCL-I showed more antimicrobial activity against E. coli and was less active against S. aureus.
Fil: de Arruda Almeida, Kleber. Universidade Federal de Itajuba; Brasil
Fil: de Queiroz, Alvaro Antonio Alencar. Universidade Federal de Itajuba; Brasil
Fil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energéticas e Nucleares; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: San Román, Julio. Instituto de Ciencia y Tecnología de Polímeros; España
description The most serious problems usually encountered in the field of implanted medical devices are the infectious morbidity as primary source of mortality. In this work, the synthesis and characterization of a macroporous iodine based sanitizer (iodophor), poly(caprolactone)-iodine, are presented. Characterization methods include nuclear magnetic resonance spectroscopy (1H NMR), gel permeation chromatography (GPC), nitrogen adsorption-desorption and scanning electron microscopy (SEM).  The in vitro cytotoxicity to CHO cells in the MTT assay and antimicrobial activities against Escherichia coli and Staphylococcus aureus were examined. The obtained macropore poly(caprolactone)-iodine structures had a rather narrow size distribution. PCL-I iodophor was non-cytotoxic to CHO cells in the MTT assay. Bactericidal activities of the PCL-I were assessed against Escherichia coli and Staphylococcus aureus. The tested PCL-I showed more antimicrobial activity against E. coli and was less active against S. aureus.
publishDate 2004
dc.date.none.fl_str_mv 2004-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98893
de Arruda Almeida, Kleber; de Queiroz, Alvaro Antonio Alencar; Higa, Olga Zazuco; Abraham, Gustavo Abel; San Román, Julio; Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 68A; 3; 3-2004; 473-478
1549-3296
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98893
identifier_str_mv de Arruda Almeida, Kleber; de Queiroz, Alvaro Antonio Alencar; Higa, Olga Zazuco; Abraham, Gustavo Abel; San Román, Julio; Macroporous poly(ϵ-caprolactone) with antimicrobial activity obtained by iodine polymerization; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 68A; 3; 3-2004; 473-478
1549-3296
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.20085
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.20085
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269933669449728
score 13.13397

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