Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism

Autores
Zanchetta, María Belén; Robbiani, Damián; Oliveri, María Beatriz; Giacoia, Evangelina; Frigeri, Adriana; Kallsbrum, Silvia; Salerni, Helena; Lucas, Sabrina; Diaz, Adriana; Perez, Betiana; Pieroni, Luisina; Arce Lange, María Auxiliadora; Tormo, Silvina; Kitaigrodsky, Ariela; Galich, Ana María
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Context:Hypoparathyroidism is a rare disease and as such, its natural history, long term complications and correct clinical management remain unclear.ObjectiveTo describe the natural history and clinical characteristics of the disease.Design and settingTopresent a retrospective observational analysis from seven specialized centers in Buenos Aires, Argentina.Patientschronic hypoparathyroid patients followed up between 1985 and December 2018.Main Outcome Measuresdata on demographics, etiology, clinical complications, biochemical parameters, DXA values and treatment doses were collected.Results322 subjects with chronic hypoparathyroidism were included, 85.7 % were female. Mean age was 55.2 ± 16.8 years and mean age at diagnosis was 43.8 ± 16.8. Prevalence of surgical hypoparathyroidism was 90.7 %, most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7 % and 4.3 % had a history of seizures. Overall, 40.9 % had reported at least one neuromuscular symptom. Renal insufficiency was present in 22.4 % and was significantly associated with age (p<0.0001). Hyperphosphatemia was present in 42 %. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures and cataracts was significantly higher in nonsurgical patients.ConclusionAlthough these patients were followed up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70 % of this group of patients met the experts´ indications for considering the use of rhPTH 1-84. Being aware of this fact is the first step to improve our medical management of this disease in the future.
Fil: Zanchetta, María Belén. Universidad del Salvador; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Robbiani, Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad del Salvador; Argentina
Fil: Oliveri, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Giacoia, Evangelina. Hospital Nacional Profesor Alejandro Posadas; Argentina
Fil: Frigeri, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Kallsbrum, Silvia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Salerni, Helena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Lucas, Sabrina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Diaz, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Perez, Betiana. Hospital Italiano; Argentina
Fil: Pieroni, Luisina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Arce Lange, María Auxiliadora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Tormo, Silvina. Hospital Nacional Profesor Alejandro Posadas.; Argentina
Fil: Kitaigrodsky, Ariela. Hospital Italiano; Argentina
Fil: Galich, Ana María. Hospital Italiano; Argentina
Materia
HYPOPARATHYROIDISM,
PTH
HYPOCALCEMIA,
HYPERPHOSPHATEMIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123045
Acceder
id CONICETDig_6bae8458060eb6500f0c59eb9b07db41
oai_identifier_str oai:ri.conicet.gov.ar:11336/123045
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hipopara-Red, Real Life Experience in 322 Patients with HypoparathyroidismZanchetta, María BelénRobbiani, DamiánOliveri, María BeatrizGiacoia, EvangelinaFrigeri, AdrianaKallsbrum, SilviaSalerni, HelenaLucas, SabrinaDiaz, AdrianaPerez, BetianaPieroni, LuisinaArce Lange, María AuxiliadoraTormo, SilvinaKitaigrodsky, ArielaGalich, Ana MaríaHYPOPARATHYROIDISM,PTHHYPOCALCEMIA,HYPERPHOSPHATEMIAhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Context:Hypoparathyroidism is a rare disease and as such, its natural history, long term complications and correct clinical management remain unclear.ObjectiveTo describe the natural history and clinical characteristics of the disease.Design and settingTopresent a retrospective observational analysis from seven specialized centers in Buenos Aires, Argentina.Patientschronic hypoparathyroid patients followed up between 1985 and December 2018.Main Outcome Measuresdata on demographics, etiology, clinical complications, biochemical parameters, DXA values and treatment doses were collected.Results322 subjects with chronic hypoparathyroidism were included, 85.7 % were female. Mean age was 55.2 ± 16.8 years and mean age at diagnosis was 43.8 ± 16.8. Prevalence of surgical hypoparathyroidism was 90.7 %, most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7 % and 4.3 % had a history of seizures. Overall, 40.9 % had reported at least one neuromuscular symptom. Renal insufficiency was present in 22.4 % and was significantly associated with age (p<0.0001). Hyperphosphatemia was present in 42 %. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures and cataracts was significantly higher in nonsurgical patients.ConclusionAlthough these patients were followed up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70 % of this group of patients met the experts´ indications for considering the use of rhPTH 1-84. Being aware of this fact is the first step to improve our medical management of this disease in the future.Fil: Zanchetta, María Belén. Universidad del Salvador; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Robbiani, Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad del Salvador; ArgentinaFil: Oliveri, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Giacoia, Evangelina. Hospital Nacional Profesor Alejandro Posadas; ArgentinaFil: Frigeri, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Kallsbrum, Silvia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Salerni, Helena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Lucas, Sabrina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; ArgentinaFil: Diaz, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; ArgentinaFil: Perez, Betiana. Hospital Italiano; ArgentinaFil: Pieroni, Luisina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Arce Lange, María Auxiliadora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Tormo, Silvina. Hospital Nacional Profesor Alejandro Posadas.; ArgentinaFil: Kitaigrodsky, Ariela. Hospital Italiano; ArgentinaFil: Galich, Ana María. Hospital Italiano; ArgentinaOxford University Press2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123045Zanchetta, María Belén; Robbiani, Damián; Oliveri, María Beatriz; Giacoia, Evangelina; Frigeri, Adriana; et al.; Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism; Oxford University Press; Journal of the Endocrine Society; 5; 2; 11-2020; 1-92472-1972CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvaa181/6007788info:eu-repo/semantics/altIdentifier/doi/10.1210/jendso/bvaa181info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:19Zoai:ri.conicet.gov.ar:11336/123045instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:20.253CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
title Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
spellingShingle Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
Zanchetta, María Belén
HYPOPARATHYROIDISM,
PTH
HYPOCALCEMIA,
HYPERPHOSPHATEMIA
title_short Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
title_full Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
title_fullStr Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
title_full_unstemmed Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
title_sort Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism
dc.creator.none.fl_str_mv Zanchetta, María Belén
Robbiani, Damián
Oliveri, María Beatriz
Giacoia, Evangelina
Frigeri, Adriana
Kallsbrum, Silvia
Salerni, Helena
Lucas, Sabrina
Diaz, Adriana
Perez, Betiana
Pieroni, Luisina
Arce Lange, María Auxiliadora
Tormo, Silvina
Kitaigrodsky, Ariela
Galich, Ana María
author Zanchetta, María Belén
author_facet Zanchetta, María Belén
Robbiani, Damián
Oliveri, María Beatriz
Giacoia, Evangelina
Frigeri, Adriana
Kallsbrum, Silvia
Salerni, Helena
Lucas, Sabrina
Diaz, Adriana
Perez, Betiana
Pieroni, Luisina
Arce Lange, María Auxiliadora
Tormo, Silvina
Kitaigrodsky, Ariela
Galich, Ana María
author_role author
author2 Robbiani, Damián
Oliveri, María Beatriz
Giacoia, Evangelina
Frigeri, Adriana
Kallsbrum, Silvia
Salerni, Helena
Lucas, Sabrina
Diaz, Adriana
Perez, Betiana
Pieroni, Luisina
Arce Lange, María Auxiliadora
Tormo, Silvina
Kitaigrodsky, Ariela
Galich, Ana María
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HYPOPARATHYROIDISM,
PTH
HYPOCALCEMIA,
HYPERPHOSPHATEMIA
topic HYPOPARATHYROIDISM,
PTH
HYPOCALCEMIA,
HYPERPHOSPHATEMIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Context:Hypoparathyroidism is a rare disease and as such, its natural history, long term complications and correct clinical management remain unclear.ObjectiveTo describe the natural history and clinical characteristics of the disease.Design and settingTopresent a retrospective observational analysis from seven specialized centers in Buenos Aires, Argentina.Patientschronic hypoparathyroid patients followed up between 1985 and December 2018.Main Outcome Measuresdata on demographics, etiology, clinical complications, biochemical parameters, DXA values and treatment doses were collected.Results322 subjects with chronic hypoparathyroidism were included, 85.7 % were female. Mean age was 55.2 ± 16.8 years and mean age at diagnosis was 43.8 ± 16.8. Prevalence of surgical hypoparathyroidism was 90.7 %, most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7 % and 4.3 % had a history of seizures. Overall, 40.9 % had reported at least one neuromuscular symptom. Renal insufficiency was present in 22.4 % and was significantly associated with age (p<0.0001). Hyperphosphatemia was present in 42 %. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures and cataracts was significantly higher in nonsurgical patients.ConclusionAlthough these patients were followed up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70 % of this group of patients met the experts´ indications for considering the use of rhPTH 1-84. Being aware of this fact is the first step to improve our medical management of this disease in the future.
Fil: Zanchetta, María Belén. Universidad del Salvador; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Robbiani, Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad del Salvador; Argentina
Fil: Oliveri, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Giacoia, Evangelina. Hospital Nacional Profesor Alejandro Posadas; Argentina
Fil: Frigeri, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Kallsbrum, Silvia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Salerni, Helena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
Fil: Lucas, Sabrina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Diaz, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Perez, Betiana. Hospital Italiano; Argentina
Fil: Pieroni, Luisina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Arce Lange, María Auxiliadora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Tormo, Silvina. Hospital Nacional Profesor Alejandro Posadas.; Argentina
Fil: Kitaigrodsky, Ariela. Hospital Italiano; Argentina
Fil: Galich, Ana María. Hospital Italiano; Argentina
description Context:Hypoparathyroidism is a rare disease and as such, its natural history, long term complications and correct clinical management remain unclear.ObjectiveTo describe the natural history and clinical characteristics of the disease.Design and settingTopresent a retrospective observational analysis from seven specialized centers in Buenos Aires, Argentina.Patientschronic hypoparathyroid patients followed up between 1985 and December 2018.Main Outcome Measuresdata on demographics, etiology, clinical complications, biochemical parameters, DXA values and treatment doses were collected.Results322 subjects with chronic hypoparathyroidism were included, 85.7 % were female. Mean age was 55.2 ± 16.8 years and mean age at diagnosis was 43.8 ± 16.8. Prevalence of surgical hypoparathyroidism was 90.7 %, most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7 % and 4.3 % had a history of seizures. Overall, 40.9 % had reported at least one neuromuscular symptom. Renal insufficiency was present in 22.4 % and was significantly associated with age (p<0.0001). Hyperphosphatemia was present in 42 %. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures and cataracts was significantly higher in nonsurgical patients.ConclusionAlthough these patients were followed up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70 % of this group of patients met the experts´ indications for considering the use of rhPTH 1-84. Being aware of this fact is the first step to improve our medical management of this disease in the future.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123045
Zanchetta, María Belén; Robbiani, Damián; Oliveri, María Beatriz; Giacoia, Evangelina; Frigeri, Adriana; et al.; Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism; Oxford University Press; Journal of the Endocrine Society; 5; 2; 11-2020; 1-9
2472-1972
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123045
identifier_str_mv Zanchetta, María Belén; Robbiani, Damián; Oliveri, María Beatriz; Giacoia, Evangelina; Frigeri, Adriana; et al.; Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism; Oxford University Press; Journal of the Endocrine Society; 5; 2; 11-2020; 1-9
2472-1972
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvaa181/6007788
info:eu-repo/semantics/altIdentifier/doi/10.1210/jendso/bvaa181
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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