VDR activation of intracellular signaling pathways in skeletal muscle

Autores
Boland, Ricardo Leopoldo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1α,25(OH) 2-vitamin D 3 [1α,25(OH) 2D 3], focusing on the role of the vitamin D receptor (VDR). The hormone induces fast, non transcriptional responses, involving stimulation of the transmembrane second messenger systems adenylyl cyclase/cAMP/PKA, PLC/DAG+IP 3/PKC, Ca 2+ messenger system and MAPK cascades. Short treatment with 1α,25(OH) 2D 3 induces reverse translocation of the VDR from the nucleus to plasma membranes. Accordingly, a complex is formed in the caveolae between the VDR and TRCP3, integral protein of capacitative Ca 2+ entry (CCE), suggesting an association between both proteins and a functional role of the VDR in 1α,25(OH) 2D 3 activation of CCE. Stimulation of tyrosine phosphorylation cascades by 1α,25(OH) 2D 3 have demonstrated the formation of complexes between Src and the VDR. Through these mechanisms, 1α,25(OH) 2D 3 plays an important function in contractility and myogenesis. © 2011 Elsevier Ireland Ltd.
Fil: Boland, Ricardo Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Materia
1Α,25(Oh) 2d 3
Cell Signaling
Muscle
Non-Genomic Effects
Vdr
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66903
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling VDR activation of intracellular signaling pathways in skeletal muscleBoland, Ricardo Leopoldo1Α,25(Oh) 2d 3Cell SignalingMuscleNon-Genomic EffectsVdrhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1α,25(OH) 2-vitamin D 3 [1α,25(OH) 2D 3], focusing on the role of the vitamin D receptor (VDR). The hormone induces fast, non transcriptional responses, involving stimulation of the transmembrane second messenger systems adenylyl cyclase/cAMP/PKA, PLC/DAG+IP 3/PKC, Ca 2+ messenger system and MAPK cascades. Short treatment with 1α,25(OH) 2D 3 induces reverse translocation of the VDR from the nucleus to plasma membranes. Accordingly, a complex is formed in the caveolae between the VDR and TRCP3, integral protein of capacitative Ca 2+ entry (CCE), suggesting an association between both proteins and a functional role of the VDR in 1α,25(OH) 2D 3 activation of CCE. Stimulation of tyrosine phosphorylation cascades by 1α,25(OH) 2D 3 have demonstrated the formation of complexes between Src and the VDR. Through these mechanisms, 1α,25(OH) 2D 3 plays an important function in contractility and myogenesis. © 2011 Elsevier Ireland Ltd.Fil: Boland, Ricardo Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaElsevier Ireland2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66903Boland, Ricardo Leopoldo; VDR activation of intracellular signaling pathways in skeletal muscle; Elsevier Ireland; Molecular and Cellular Endocrinology; 347; 1-2; 12-2011; 11-160303-7207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720711002735info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2011.05.021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:09:24Zoai:ri.conicet.gov.ar:11336/66903instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:09:25.258CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv VDR activation of intracellular signaling pathways in skeletal muscle
title VDR activation of intracellular signaling pathways in skeletal muscle
spellingShingle VDR activation of intracellular signaling pathways in skeletal muscle
Boland, Ricardo Leopoldo
1Α,25(Oh) 2d 3
Cell Signaling
Muscle
Non-Genomic Effects
Vdr
title_short VDR activation of intracellular signaling pathways in skeletal muscle
title_full VDR activation of intracellular signaling pathways in skeletal muscle
title_fullStr VDR activation of intracellular signaling pathways in skeletal muscle
title_full_unstemmed VDR activation of intracellular signaling pathways in skeletal muscle
title_sort VDR activation of intracellular signaling pathways in skeletal muscle
dc.creator.none.fl_str_mv Boland, Ricardo Leopoldo
author Boland, Ricardo Leopoldo
author_facet Boland, Ricardo Leopoldo
author_role author
dc.subject.none.fl_str_mv 1Α,25(Oh) 2d 3
Cell Signaling
Muscle
Non-Genomic Effects
Vdr
topic 1Α,25(Oh) 2d 3
Cell Signaling
Muscle
Non-Genomic Effects
Vdr
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1α,25(OH) 2-vitamin D 3 [1α,25(OH) 2D 3], focusing on the role of the vitamin D receptor (VDR). The hormone induces fast, non transcriptional responses, involving stimulation of the transmembrane second messenger systems adenylyl cyclase/cAMP/PKA, PLC/DAG+IP 3/PKC, Ca 2+ messenger system and MAPK cascades. Short treatment with 1α,25(OH) 2D 3 induces reverse translocation of the VDR from the nucleus to plasma membranes. Accordingly, a complex is formed in the caveolae between the VDR and TRCP3, integral protein of capacitative Ca 2+ entry (CCE), suggesting an association between both proteins and a functional role of the VDR in 1α,25(OH) 2D 3 activation of CCE. Stimulation of tyrosine phosphorylation cascades by 1α,25(OH) 2D 3 have demonstrated the formation of complexes between Src and the VDR. Through these mechanisms, 1α,25(OH) 2D 3 plays an important function in contractility and myogenesis. © 2011 Elsevier Ireland Ltd.
Fil: Boland, Ricardo Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
description The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1α,25(OH) 2-vitamin D 3 [1α,25(OH) 2D 3], focusing on the role of the vitamin D receptor (VDR). The hormone induces fast, non transcriptional responses, involving stimulation of the transmembrane second messenger systems adenylyl cyclase/cAMP/PKA, PLC/DAG+IP 3/PKC, Ca 2+ messenger system and MAPK cascades. Short treatment with 1α,25(OH) 2D 3 induces reverse translocation of the VDR from the nucleus to plasma membranes. Accordingly, a complex is formed in the caveolae between the VDR and TRCP3, integral protein of capacitative Ca 2+ entry (CCE), suggesting an association between both proteins and a functional role of the VDR in 1α,25(OH) 2D 3 activation of CCE. Stimulation of tyrosine phosphorylation cascades by 1α,25(OH) 2D 3 have demonstrated the formation of complexes between Src and the VDR. Through these mechanisms, 1α,25(OH) 2D 3 plays an important function in contractility and myogenesis. © 2011 Elsevier Ireland Ltd.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66903
Boland, Ricardo Leopoldo; VDR activation of intracellular signaling pathways in skeletal muscle; Elsevier Ireland; Molecular and Cellular Endocrinology; 347; 1-2; 12-2011; 11-16
0303-7207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66903
identifier_str_mv Boland, Ricardo Leopoldo; VDR activation of intracellular signaling pathways in skeletal muscle; Elsevier Ireland; Molecular and Cellular Endocrinology; 347; 1-2; 12-2011; 11-16
0303-7207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720711002735
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2011.05.021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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