Memory persistence: From fundamental mechanisms to translational opportunities
- Autores
- Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals.
Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Merlo, Emiliano. University of Sussex; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina - Materia
-
Memory persistence
Anxiety disorders
Pharmacological and behavioral interventions
Traslational research - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/261107
Ver los metadatos del registro completo
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Memory persistence: From fundamental mechanisms to translational opportunitiesMerlo, Santiago AbelBelluscio, Mariano AndresPedreira, Maria EugeniaMerlo, EmilianoMemory persistenceAnxiety disordersPharmacological and behavioral interventionsTraslational researchhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals.Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Merlo, Emiliano. University of Sussex; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaNature Publishing Group2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261107Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano; Memory persistence: From fundamental mechanisms to translational opportunities; Nature Publishing Group; Translational Psychiatry; 14; 1; 2-2024; 1-82158-3188CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41398-024-02808-zinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41398-024-02808-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:04Zoai:ri.conicet.gov.ar:11336/261107instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:04.983CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Memory persistence: From fundamental mechanisms to translational opportunities |
title |
Memory persistence: From fundamental mechanisms to translational opportunities |
spellingShingle |
Memory persistence: From fundamental mechanisms to translational opportunities Merlo, Santiago Abel Memory persistence Anxiety disorders Pharmacological and behavioral interventions Traslational research |
title_short |
Memory persistence: From fundamental mechanisms to translational opportunities |
title_full |
Memory persistence: From fundamental mechanisms to translational opportunities |
title_fullStr |
Memory persistence: From fundamental mechanisms to translational opportunities |
title_full_unstemmed |
Memory persistence: From fundamental mechanisms to translational opportunities |
title_sort |
Memory persistence: From fundamental mechanisms to translational opportunities |
dc.creator.none.fl_str_mv |
Merlo, Santiago Abel Belluscio, Mariano Andres Pedreira, Maria Eugenia Merlo, Emiliano |
author |
Merlo, Santiago Abel |
author_facet |
Merlo, Santiago Abel Belluscio, Mariano Andres Pedreira, Maria Eugenia Merlo, Emiliano |
author_role |
author |
author2 |
Belluscio, Mariano Andres Pedreira, Maria Eugenia Merlo, Emiliano |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Memory persistence Anxiety disorders Pharmacological and behavioral interventions Traslational research |
topic |
Memory persistence Anxiety disorders Pharmacological and behavioral interventions Traslational research |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals. Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina Fil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Merlo, Emiliano. University of Sussex; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina |
description |
Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/261107 Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano; Memory persistence: From fundamental mechanisms to translational opportunities; Nature Publishing Group; Translational Psychiatry; 14; 1; 2-2024; 1-8 2158-3188 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/261107 |
identifier_str_mv |
Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano; Memory persistence: From fundamental mechanisms to translational opportunities; Nature Publishing Group; Translational Psychiatry; 14; 1; 2-2024; 1-8 2158-3188 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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