Memory persistence: From fundamental mechanisms to translational opportunities

Autores
Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals.
Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Merlo, Emiliano. University of Sussex; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Materia
Memory persistence
Anxiety disorders
Pharmacological and behavioral interventions
Traslational research
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/261107

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spelling Memory persistence: From fundamental mechanisms to translational opportunitiesMerlo, Santiago AbelBelluscio, Mariano AndresPedreira, Maria EugeniaMerlo, EmilianoMemory persistenceAnxiety disordersPharmacological and behavioral interventionsTraslational researchhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals.Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Merlo, Emiliano. University of Sussex; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaNature Publishing Group2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261107Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano; Memory persistence: From fundamental mechanisms to translational opportunities; Nature Publishing Group; Translational Psychiatry; 14; 1; 2-2024; 1-82158-3188CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41398-024-02808-zinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41398-024-02808-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:04Zoai:ri.conicet.gov.ar:11336/261107instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:04.983CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Memory persistence: From fundamental mechanisms to translational opportunities
title Memory persistence: From fundamental mechanisms to translational opportunities
spellingShingle Memory persistence: From fundamental mechanisms to translational opportunities
Merlo, Santiago Abel
Memory persistence
Anxiety disorders
Pharmacological and behavioral interventions
Traslational research
title_short Memory persistence: From fundamental mechanisms to translational opportunities
title_full Memory persistence: From fundamental mechanisms to translational opportunities
title_fullStr Memory persistence: From fundamental mechanisms to translational opportunities
title_full_unstemmed Memory persistence: From fundamental mechanisms to translational opportunities
title_sort Memory persistence: From fundamental mechanisms to translational opportunities
dc.creator.none.fl_str_mv Merlo, Santiago Abel
Belluscio, Mariano Andres
Pedreira, Maria Eugenia
Merlo, Emiliano
author Merlo, Santiago Abel
author_facet Merlo, Santiago Abel
Belluscio, Mariano Andres
Pedreira, Maria Eugenia
Merlo, Emiliano
author_role author
author2 Belluscio, Mariano Andres
Pedreira, Maria Eugenia
Merlo, Emiliano
author2_role author
author
author
dc.subject.none.fl_str_mv Memory persistence
Anxiety disorders
Pharmacological and behavioral interventions
Traslational research
topic Memory persistence
Anxiety disorders
Pharmacological and behavioral interventions
Traslational research
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals.
Fil: Merlo, Santiago Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Merlo, Emiliano. University of Sussex; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
description Memory is a fundamental attribute of animal cognition that allows individuals to store and retrieve information about past experiences. The interplay between the processes of maintenance and inhibition enables memory to fulfill its primary role, to use previous experiences to optimise decision-making and fitness in a constantly evolving and unpredictable environment [1]. Current hypotheses state that memories are stored through maintenance of synaptic connections between neuronal subgroups and are not immutable. They can be challenged by active forgetting, and retrieval-dependent mechanisms triggered by memory prediction error; as well as subject to decay via inhibitory processes that limit memory persistence. The balance between maintenance and inhibition mechanisms will ultimately determine memory existence, modulating its strength and duration. Here we review the neurobiological mechanism of memory formation, persistence and forgetting with evidence from human and non human animals.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/261107
Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano; Memory persistence: From fundamental mechanisms to translational opportunities; Nature Publishing Group; Translational Psychiatry; 14; 1; 2-2024; 1-8
2158-3188
CONICET Digital
CONICET
url http://hdl.handle.net/11336/261107
identifier_str_mv Merlo, Santiago Abel; Belluscio, Mariano Andres; Pedreira, Maria Eugenia; Merlo, Emiliano; Memory persistence: From fundamental mechanisms to translational opportunities; Nature Publishing Group; Translational Psychiatry; 14; 1; 2-2024; 1-8
2158-3188
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
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