Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

Autores
Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; Palermo, Jorge Alejandro; Meijer, Laurent
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed.
Fil: Gompel, Marie. Centre National de la Recherche Scientifique; Francia
Fil: Leost, Maryse. Centre National de la Recherche Scientifique; Francia
Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Hernandez Franco, Laura. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Palermo, Jorge Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Meijer, Laurent. Centre National de la Recherche Scientifique; Francia
Materia
CANCER
CDK
CYCLIN-DEPENDENT KINASE
GLYCOGEN SYNTHASE KINASE
GLYCOGEN SYNTHASE KINASE-3
GSK-3
KINASE INHIBITOR
MEM
MERIDIANIN
MODIFIED EAGLE MEDIUM
MTT
NEURODEGENERATIVE DISEASES
PROTEIN KINASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85359
Acceder
id CONICETDig_691f305b338e2da20a3519d76d31f7b3
oai_identifier_str oai:ri.conicet.gov.ar:11336/85359
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianumGompel, MarieLeost, MaryseBal, Elisa DoraPuricelli, Lydia InesHernandez Franco, LauraPalermo, Jorge AlejandroMeijer, LaurentCANCERCDKCYCLIN-DEPENDENT KINASEGLYCOGEN SYNTHASE KINASEGLYCOGEN SYNTHASE KINASE-3GSK-3KINASE INHIBITORMEMMERIDIANINMODIFIED EAGLE MEDIUMMTTNEURODEGENERATIVE DISEASESPROTEIN KINASEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed.Fil: Gompel, Marie. Centre National de la Recherche Scientifique; FranciaFil: Leost, Maryse. Centre National de la Recherche Scientifique; FranciaFil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Hernandez Franco, Laura. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Palermo, Jorge Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Meijer, Laurent. Centre National de la Recherche Scientifique; FranciaPergamon-Elsevier Science Ltd2004-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85359Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; et al.; Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 7; 4-2004; 1703-17070960-894XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.01.050info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X04001301info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:53:38Zoai:ri.conicet.gov.ar:11336/85359instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:53:38.288CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
spellingShingle Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
Gompel, Marie
CANCER
CDK
CYCLIN-DEPENDENT KINASE
GLYCOGEN SYNTHASE KINASE
GLYCOGEN SYNTHASE KINASE-3
GSK-3
KINASE INHIBITOR
MEM
MERIDIANIN
MODIFIED EAGLE MEDIUM
MTT
NEURODEGENERATIVE DISEASES
PROTEIN KINASE
title_short Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_full Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_fullStr Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_full_unstemmed Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_sort Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
dc.creator.none.fl_str_mv Gompel, Marie
Leost, Maryse
Bal, Elisa Dora
Puricelli, Lydia Ines
Hernandez Franco, Laura
Palermo, Jorge Alejandro
Meijer, Laurent
author Gompel, Marie
author_facet Gompel, Marie
Leost, Maryse
Bal, Elisa Dora
Puricelli, Lydia Ines
Hernandez Franco, Laura
Palermo, Jorge Alejandro
Meijer, Laurent
author_role author
author2 Leost, Maryse
Bal, Elisa Dora
Puricelli, Lydia Ines
Hernandez Franco, Laura
Palermo, Jorge Alejandro
Meijer, Laurent
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER
CDK
CYCLIN-DEPENDENT KINASE
GLYCOGEN SYNTHASE KINASE
GLYCOGEN SYNTHASE KINASE-3
GSK-3
KINASE INHIBITOR
MEM
MERIDIANIN
MODIFIED EAGLE MEDIUM
MTT
NEURODEGENERATIVE DISEASES
PROTEIN KINASE
topic CANCER
CDK
CYCLIN-DEPENDENT KINASE
GLYCOGEN SYNTHASE KINASE
GLYCOGEN SYNTHASE KINASE-3
GSK-3
KINASE INHIBITOR
MEM
MERIDIANIN
MODIFIED EAGLE MEDIUM
MTT
NEURODEGENERATIVE DISEASES
PROTEIN KINASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed.
Fil: Gompel, Marie. Centre National de la Recherche Scientifique; Francia
Fil: Leost, Maryse. Centre National de la Recherche Scientifique; Francia
Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Hernandez Franco, Laura. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Palermo, Jorge Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Meijer, Laurent. Centre National de la Recherche Scientifique; Francia
description Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed.
publishDate 2004
dc.date.none.fl_str_mv 2004-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85359
Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; et al.; Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 7; 4-2004; 1703-1707
0960-894X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85359
identifier_str_mv Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; et al.; Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 7; 4-2004; 1703-1707
0960-894X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.01.050
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X04001301
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848598227212828672
score 13.24909

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