Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
- Autores
- Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; Palermo, Jorge Alejandro; Meijer, Laurent
- Año de publicación
- 2004
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed.
Fil: Gompel, Marie. Centre National de la Recherche Scientifique; Francia
Fil: Leost, Maryse. Centre National de la Recherche Scientifique; Francia
Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Hernandez Franco, Laura. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Palermo, Jorge Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Meijer, Laurent. Centre National de la Recherche Scientifique; Francia - Materia
-
CANCER
CDK
CYCLIN-DEPENDENT KINASE
GLYCOGEN SYNTHASE KINASE
GLYCOGEN SYNTHASE KINASE-3
GSK-3
KINASE INHIBITOR
MEM
MERIDIANIN
MODIFIED EAGLE MEDIUM
MTT
NEURODEGENERATIVE DISEASES
PROTEIN KINASE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/85359
Ver los metadatos del registro completo
id |
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oai_identifier_str |
oai:ri.conicet.gov.ar:11336/85359 |
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CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianumGompel, MarieLeost, MaryseBal, Elisa DoraPuricelli, Lydia InesHernandez Franco, LauraPalermo, Jorge AlejandroMeijer, LaurentCANCERCDKCYCLIN-DEPENDENT KINASEGLYCOGEN SYNTHASE KINASEGLYCOGEN SYNTHASE KINASE-3GSK-3KINASE INHIBITORMEMMERIDIANINMODIFIED EAGLE MEDIUMMTTNEURODEGENERATIVE DISEASESPROTEIN KINASEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed.Fil: Gompel, Marie. Centre National de la Recherche Scientifique; FranciaFil: Leost, Maryse. Centre National de la Recherche Scientifique; FranciaFil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Hernandez Franco, Laura. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Palermo, Jorge Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Meijer, Laurent. Centre National de la Recherche Scientifique; FranciaPergamon-Elsevier Science Ltd2004-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85359Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; et al.; Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 7; 4-2004; 1703-17070960-894XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.01.050info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X04001301info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:36Zoai:ri.conicet.gov.ar:11336/85359instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:37.153CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
spellingShingle |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum Gompel, Marie CANCER CDK CYCLIN-DEPENDENT KINASE GLYCOGEN SYNTHASE KINASE GLYCOGEN SYNTHASE KINASE-3 GSK-3 KINASE INHIBITOR MEM MERIDIANIN MODIFIED EAGLE MEDIUM MTT NEURODEGENERATIVE DISEASES PROTEIN KINASE |
title_short |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_full |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_fullStr |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_full_unstemmed |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
title_sort |
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum |
dc.creator.none.fl_str_mv |
Gompel, Marie Leost, Maryse Bal, Elisa Dora Puricelli, Lydia Ines Hernandez Franco, Laura Palermo, Jorge Alejandro Meijer, Laurent |
author |
Gompel, Marie |
author_facet |
Gompel, Marie Leost, Maryse Bal, Elisa Dora Puricelli, Lydia Ines Hernandez Franco, Laura Palermo, Jorge Alejandro Meijer, Laurent |
author_role |
author |
author2 |
Leost, Maryse Bal, Elisa Dora Puricelli, Lydia Ines Hernandez Franco, Laura Palermo, Jorge Alejandro Meijer, Laurent |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
CANCER CDK CYCLIN-DEPENDENT KINASE GLYCOGEN SYNTHASE KINASE GLYCOGEN SYNTHASE KINASE-3 GSK-3 KINASE INHIBITOR MEM MERIDIANIN MODIFIED EAGLE MEDIUM MTT NEURODEGENERATIVE DISEASES PROTEIN KINASE |
topic |
CANCER CDK CYCLIN-DEPENDENT KINASE GLYCOGEN SYNTHASE KINASE GLYCOGEN SYNTHASE KINASE-3 GSK-3 KINASE INHIBITOR MEM MERIDIANIN MODIFIED EAGLE MEDIUM MTT NEURODEGENERATIVE DISEASES PROTEIN KINASE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. Fil: Gompel, Marie. Centre National de la Recherche Scientifique; Francia Fil: Leost, Maryse. Centre National de la Recherche Scientifique; Francia Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina Fil: Hernandez Franco, Laura. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Palermo, Jorge Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina Fil: Meijer, Laurent. Centre National de la Recherche Scientifique; Francia |
description |
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/85359 Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; et al.; Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 7; 4-2004; 1703-1707 0960-894X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/85359 |
identifier_str_mv |
Gompel, Marie; Leost, Maryse; Bal, Elisa Dora; Puricelli, Lydia Ines; Hernandez Franco, Laura; et al.; Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 7; 4-2004; 1703-1707 0960-894X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.01.050 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X04001301 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614242780577792 |
score |
13.070432 |