Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite

Autores
Albano, Maria Patricia; Calambas Pulgarin, Heydy Lorena; Garrido, Liliana Beatriz; Ferraz, Emanuela Prado; Rosa, Adalberto L.; De Oliveira, Paulo Tambasco
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two commercial 3 mol% yttria-partially stabilized zirconia powders, with 0.3 wt% Al2O3 (YZA) and without Al2O3 (YZ), were used to produce alumina (Al2O3)-zirconia (ZrO2) slip cast composites. The influence of the ZrO2 content and the ZrO2 grain size on the ageing behavior of the different Al2O3-ZrO2 composites was investigated. In addition, the in vitro biocompatibility and osteogenic cell differentiation of Al2O3-ZrO2 surfaces were evaluated before ageing (ba) and after ageing (aa) using the rat bone marrow-derived osteoblast cell culture model; the osteogenic potential of preosteoblast MC3T3-E1 cells on the same surfaces was also assessed. The ageing susceptibility of the composites significantly increased with increasing the ZrO2 content over 22 vol%. For ZrO2 contents ≤22 vol%, the grain size did not influence the transformability of tetragonal ZrO2 under ageing conditions; however, in the composites with 50 vol%, the greater grain size of 50 vol% YZ with respect to 50 vol% YZA enhanced the ageing degradation. Overall, the cell culture experiments revealed no significant differences among the composites before ageing in terms of osteogenic cell differentiation, except for the higher mineralization of bone marrow-derived osteoblast cells grown on 50 vol% YZ ba compared with the ones grown on 50 vol% YZA ba. The ageing process tended to rescue the osteogenic potential of these cells grown on 50 vol% YZA while inhibiting the one on 50 vol% YZ. In conclusion, the low ageing sensitive of the composites with ZrO2 contents ≤22 vol% did not change the osteoblast biocompatibility, whereas the greater ageing degradation of the composites with 50 vol% ZrO2 seemed to alter the osteogenic potential of bone marrow-derived osteoblast cells.
Fil: Albano, Maria Patricia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Calambas Pulgarin, Heydy Lorena. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Ferraz, Emanuela Prado. Universidade de Sao Paulo; Brasil
Fil: Rosa, Adalberto L.. Universidade de Sao Paulo; Brasil
Fil: De Oliveira, Paulo Tambasco. Universidade de Sao Paulo; Brasil
Materia
AGEING BEHAVIOR
AL2O3-ZRO2
MINERALIZATION
OSTEOBLAST CELL CULTURES
PHASE TRANSFORMATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/100484
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/100484
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 compositeAlbano, Maria PatriciaCalambas Pulgarin, Heydy LorenaGarrido, Liliana BeatrizFerraz, Emanuela PradoRosa, Adalberto L.De Oliveira, Paulo TambascoAGEING BEHAVIORAL2O3-ZRO2MINERALIZATIONOSTEOBLAST CELL CULTURESPHASE TRANSFORMATIONhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Two commercial 3 mol% yttria-partially stabilized zirconia powders, with 0.3 wt% Al2O3 (YZA) and without Al2O3 (YZ), were used to produce alumina (Al2O3)-zirconia (ZrO2) slip cast composites. The influence of the ZrO2 content and the ZrO2 grain size on the ageing behavior of the different Al2O3-ZrO2 composites was investigated. In addition, the in vitro biocompatibility and osteogenic cell differentiation of Al2O3-ZrO2 surfaces were evaluated before ageing (ba) and after ageing (aa) using the rat bone marrow-derived osteoblast cell culture model; the osteogenic potential of preosteoblast MC3T3-E1 cells on the same surfaces was also assessed. The ageing susceptibility of the composites significantly increased with increasing the ZrO2 content over 22 vol%. For ZrO2 contents ≤22 vol%, the grain size did not influence the transformability of tetragonal ZrO2 under ageing conditions; however, in the composites with 50 vol%, the greater grain size of 50 vol% YZ with respect to 50 vol% YZA enhanced the ageing degradation. Overall, the cell culture experiments revealed no significant differences among the composites before ageing in terms of osteogenic cell differentiation, except for the higher mineralization of bone marrow-derived osteoblast cells grown on 50 vol% YZ ba compared with the ones grown on 50 vol% YZA ba. The ageing process tended to rescue the osteogenic potential of these cells grown on 50 vol% YZA while inhibiting the one on 50 vol% YZ. In conclusion, the low ageing sensitive of the composites with ZrO2 contents ≤22 vol% did not change the osteoblast biocompatibility, whereas the greater ageing degradation of the composites with 50 vol% ZrO2 seemed to alter the osteogenic potential of bone marrow-derived osteoblast cells.Fil: Albano, Maria Patricia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Calambas Pulgarin, Heydy Lorena. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Ferraz, Emanuela Prado. Universidade de Sao Paulo; BrasilFil: Rosa, Adalberto L.. Universidade de Sao Paulo; BrasilFil: De Oliveira, Paulo Tambasco. Universidade de Sao Paulo; BrasilElsevier2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100484Albano, Maria Patricia; Calambas Pulgarin, Heydy Lorena; Garrido, Liliana Beatriz; Ferraz, Emanuela Prado; Rosa, Adalberto L.; et al.; Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite; Elsevier; Ceramics International; 42; 9; 7-2016; 11363-113720272-8842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0272884216304576info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceramint.2016.04.063info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:14Zoai:ri.conicet.gov.ar:11336/100484instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:14.709CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
title Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
spellingShingle Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
Albano, Maria Patricia
AGEING BEHAVIOR
AL2O3-ZRO2
MINERALIZATION
OSTEOBLAST CELL CULTURES
PHASE TRANSFORMATION
title_short Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
title_full Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
title_fullStr Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
title_full_unstemmed Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
title_sort Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite
dc.creator.none.fl_str_mv Albano, Maria Patricia
Calambas Pulgarin, Heydy Lorena
Garrido, Liliana Beatriz
Ferraz, Emanuela Prado
Rosa, Adalberto L.
De Oliveira, Paulo Tambasco
author Albano, Maria Patricia
author_facet Albano, Maria Patricia
Calambas Pulgarin, Heydy Lorena
Garrido, Liliana Beatriz
Ferraz, Emanuela Prado
Rosa, Adalberto L.
De Oliveira, Paulo Tambasco
author_role author
author2 Calambas Pulgarin, Heydy Lorena
Garrido, Liliana Beatriz
Ferraz, Emanuela Prado
Rosa, Adalberto L.
De Oliveira, Paulo Tambasco
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AGEING BEHAVIOR
AL2O3-ZRO2
MINERALIZATION
OSTEOBLAST CELL CULTURES
PHASE TRANSFORMATION
topic AGEING BEHAVIOR
AL2O3-ZRO2
MINERALIZATION
OSTEOBLAST CELL CULTURES
PHASE TRANSFORMATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Two commercial 3 mol% yttria-partially stabilized zirconia powders, with 0.3 wt% Al2O3 (YZA) and without Al2O3 (YZ), were used to produce alumina (Al2O3)-zirconia (ZrO2) slip cast composites. The influence of the ZrO2 content and the ZrO2 grain size on the ageing behavior of the different Al2O3-ZrO2 composites was investigated. In addition, the in vitro biocompatibility and osteogenic cell differentiation of Al2O3-ZrO2 surfaces were evaluated before ageing (ba) and after ageing (aa) using the rat bone marrow-derived osteoblast cell culture model; the osteogenic potential of preosteoblast MC3T3-E1 cells on the same surfaces was also assessed. The ageing susceptibility of the composites significantly increased with increasing the ZrO2 content over 22 vol%. For ZrO2 contents ≤22 vol%, the grain size did not influence the transformability of tetragonal ZrO2 under ageing conditions; however, in the composites with 50 vol%, the greater grain size of 50 vol% YZ with respect to 50 vol% YZA enhanced the ageing degradation. Overall, the cell culture experiments revealed no significant differences among the composites before ageing in terms of osteogenic cell differentiation, except for the higher mineralization of bone marrow-derived osteoblast cells grown on 50 vol% YZ ba compared with the ones grown on 50 vol% YZA ba. The ageing process tended to rescue the osteogenic potential of these cells grown on 50 vol% YZA while inhibiting the one on 50 vol% YZ. In conclusion, the low ageing sensitive of the composites with ZrO2 contents ≤22 vol% did not change the osteoblast biocompatibility, whereas the greater ageing degradation of the composites with 50 vol% ZrO2 seemed to alter the osteogenic potential of bone marrow-derived osteoblast cells.
Fil: Albano, Maria Patricia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Calambas Pulgarin, Heydy Lorena. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Ferraz, Emanuela Prado. Universidade de Sao Paulo; Brasil
Fil: Rosa, Adalberto L.. Universidade de Sao Paulo; Brasil
Fil: De Oliveira, Paulo Tambasco. Universidade de Sao Paulo; Brasil
description Two commercial 3 mol% yttria-partially stabilized zirconia powders, with 0.3 wt% Al2O3 (YZA) and without Al2O3 (YZ), were used to produce alumina (Al2O3)-zirconia (ZrO2) slip cast composites. The influence of the ZrO2 content and the ZrO2 grain size on the ageing behavior of the different Al2O3-ZrO2 composites was investigated. In addition, the in vitro biocompatibility and osteogenic cell differentiation of Al2O3-ZrO2 surfaces were evaluated before ageing (ba) and after ageing (aa) using the rat bone marrow-derived osteoblast cell culture model; the osteogenic potential of preosteoblast MC3T3-E1 cells on the same surfaces was also assessed. The ageing susceptibility of the composites significantly increased with increasing the ZrO2 content over 22 vol%. For ZrO2 contents ≤22 vol%, the grain size did not influence the transformability of tetragonal ZrO2 under ageing conditions; however, in the composites with 50 vol%, the greater grain size of 50 vol% YZ with respect to 50 vol% YZA enhanced the ageing degradation. Overall, the cell culture experiments revealed no significant differences among the composites before ageing in terms of osteogenic cell differentiation, except for the higher mineralization of bone marrow-derived osteoblast cells grown on 50 vol% YZ ba compared with the ones grown on 50 vol% YZA ba. The ageing process tended to rescue the osteogenic potential of these cells grown on 50 vol% YZA while inhibiting the one on 50 vol% YZ. In conclusion, the low ageing sensitive of the composites with ZrO2 contents ≤22 vol% did not change the osteoblast biocompatibility, whereas the greater ageing degradation of the composites with 50 vol% ZrO2 seemed to alter the osteogenic potential of bone marrow-derived osteoblast cells.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/100484
Albano, Maria Patricia; Calambas Pulgarin, Heydy Lorena; Garrido, Liliana Beatriz; Ferraz, Emanuela Prado; Rosa, Adalberto L.; et al.; Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite; Elsevier; Ceramics International; 42; 9; 7-2016; 11363-11372
0272-8842
CONICET Digital
CONICET
url http://hdl.handle.net/11336/100484
identifier_str_mv Albano, Maria Patricia; Calambas Pulgarin, Heydy Lorena; Garrido, Liliana Beatriz; Ferraz, Emanuela Prado; Rosa, Adalberto L.; et al.; Effect of ZrO2 content on ageing resistance and osteogenic cell differentiation of ZrO2-Al2O3 composite; Elsevier; Ceramics International; 42; 9; 7-2016; 11363-11372
0272-8842
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0272884216304576
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceramint.2016.04.063
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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