Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease
- Autores
- Perez Lloret, Santiago; Negre Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Paul; Destée, Alain; Meissner, Wassilios G.; Schelosky, Ludwig; Tison, Francois; Rascol, Olivier
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- IMPORTANCE: Freezing of gait (FOG) is a common axial symptom of Parkinson disease (PD). OBJECTIVE: To determine the prevalence of FOG in a large group of PD patients, assess its relationship with quality of life and clinical and pharmacological factors, and explore its changes from the off to on conditions in patients with motor fluctuations. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional survey of 683 patients with idiopathic PD. Scores for FOG were missing in 11 patients who were not included in the analysis. Patients were recruited from referral centers and general neurology clinics in public or private institutions in France. EXPOSURE: Patients with FOG were identified as those with a score of 1 or greater on item 14 of the Unified Parkinson's Disease Rating Scale (UPDRS) in the on condition. Item 14 scores for FOG in the off condition were also collected in patients with fluctuating motor symptoms. MAIN OUTCOMES AND MEASURES: Quality of life (measured by the 39-item Parkinson's Disease Questionnaire and 36-Item Short Form Health Survey), anxiety and depression (Hospital Anxiety and Depression Scale), clinical features (UPDRS), and drug consumption. RESULTS: Of 672 PD patients, 257 reported FOG during the onstate (38.2%), which was significantly related to lower quality of life scores (P < .01). Freezing of gait was also correlated with longer PD duration (odds ratio, 1.92 [95% CI, 1.28-2.86]), higher UPDRS parts II and III scores (4.67 [3.21-6.78]), the presence of apathy (UPDRS item 4) (1.94 [1.33-2.82]), a higher levodopa equivalent daily dose (1.63 [1.09-2.43]), and more frequent exposure to antimuscarinics (3.07 [1.35-6.97]) (logistic regression). The FOG score improved from the off to on states in 148 of 174 patients with motor fluctuations (85.1%) and showed no change in 13.8%. The FOG score improved by more than 50% in 43.7% of patients. Greater improvement in the on state was observed in younger patients (r = -0.25; P < .01) with lower UPDRS II and III scores (r = -0.50; P < .01) and no antimuscarinic use (r = -0.21; P < .01). CONCLUSIONS AND RELEVANCE: Freezing of gait in PD patients correlates with poor quality of life, disease severity, apathy, and exposure to antimuscarinics. Dopaminergic therapy improved FOG in most patients with motor fluctuations, especially younger ones with less severe disease and no antimuscarinic use. This finding suggests that quality of life is impaired in PD patients with FOG and that optimizing dopaminergic therapy and avoiding antimuscarinics should be considered.
Fil: Perez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. University of Toulouse; Argentina. Inserm; Francia
Fil: Negre Pages, Laurence. LN Pharma; Francia
Fil: Damier, Philippe. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Nantes; Francia
Fil: Delval, Arnaud. Centre Hospitalier Universitaire (CHU) Lille; Francia
Fil: Derkinderen, Paul. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Nantes; Francia
Fil: Destée, Alain. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Lille; Francia
Fil: Meissner, Wassilios G.. Centre National de la Recherche Scientifique; Francia. Centre Hospitalier Universitaire (CHU) Bordeaux; Francia. Universite de Bordeaux; Francia
Fil: Schelosky, Ludwig. Kantonsspital Münsterlingen; Suiza
Fil: Tison, Francois. Universite de Bordeaux; Francia. Centre National de la Recherche Scientifique; Francia. Centre Hospitalier Universitaire (CHU) Bordeaux; Francia
Fil: Rascol, Olivier. Inserm; Francia - Materia
-
Parkinson disease
Movement disorders
Quality of life
Medical Treatment - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/16126
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Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson diseasePerez Lloret, SantiagoNegre Pages, LaurenceDamier, PhilippeDelval, ArnaudDerkinderen, PaulDestée, AlainMeissner, Wassilios G.Schelosky, LudwigTison, FrancoisRascol, OlivierParkinson diseaseMovement disordersQuality of lifeMedical Treatmenthttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3IMPORTANCE: Freezing of gait (FOG) is a common axial symptom of Parkinson disease (PD). OBJECTIVE: To determine the prevalence of FOG in a large group of PD patients, assess its relationship with quality of life and clinical and pharmacological factors, and explore its changes from the off to on conditions in patients with motor fluctuations. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional survey of 683 patients with idiopathic PD. Scores for FOG were missing in 11 patients who were not included in the analysis. Patients were recruited from referral centers and general neurology clinics in public or private institutions in France. EXPOSURE: Patients with FOG were identified as those with a score of 1 or greater on item 14 of the Unified Parkinson's Disease Rating Scale (UPDRS) in the on condition. Item 14 scores for FOG in the off condition were also collected in patients with fluctuating motor symptoms. MAIN OUTCOMES AND MEASURES: Quality of life (measured by the 39-item Parkinson's Disease Questionnaire and 36-Item Short Form Health Survey), anxiety and depression (Hospital Anxiety and Depression Scale), clinical features (UPDRS), and drug consumption. RESULTS: Of 672 PD patients, 257 reported FOG during the onstate (38.2%), which was significantly related to lower quality of life scores (P < .01). Freezing of gait was also correlated with longer PD duration (odds ratio, 1.92 [95% CI, 1.28-2.86]), higher UPDRS parts II and III scores (4.67 [3.21-6.78]), the presence of apathy (UPDRS item 4) (1.94 [1.33-2.82]), a higher levodopa equivalent daily dose (1.63 [1.09-2.43]), and more frequent exposure to antimuscarinics (3.07 [1.35-6.97]) (logistic regression). The FOG score improved from the off to on states in 148 of 174 patients with motor fluctuations (85.1%) and showed no change in 13.8%. The FOG score improved by more than 50% in 43.7% of patients. Greater improvement in the on state was observed in younger patients (r = -0.25; P < .01) with lower UPDRS II and III scores (r = -0.50; P < .01) and no antimuscarinic use (r = -0.21; P < .01). CONCLUSIONS AND RELEVANCE: Freezing of gait in PD patients correlates with poor quality of life, disease severity, apathy, and exposure to antimuscarinics. Dopaminergic therapy improved FOG in most patients with motor fluctuations, especially younger ones with less severe disease and no antimuscarinic use. This finding suggests that quality of life is impaired in PD patients with FOG and that optimizing dopaminergic therapy and avoiding antimuscarinics should be considered.Fil: Perez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. University of Toulouse; Argentina. Inserm; FranciaFil: Negre Pages, Laurence. LN Pharma; FranciaFil: Damier, Philippe. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Nantes; FranciaFil: Delval, Arnaud. Centre Hospitalier Universitaire (CHU) Lille; FranciaFil: Derkinderen, Paul. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Nantes; FranciaFil: Destée, Alain. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Lille; FranciaFil: Meissner, Wassilios G.. Centre National de la Recherche Scientifique; Francia. Centre Hospitalier Universitaire (CHU) Bordeaux; Francia. Universite de Bordeaux; FranciaFil: Schelosky, Ludwig. Kantonsspital Münsterlingen; SuizaFil: Tison, Francois. Universite de Bordeaux; Francia. Centre National de la Recherche Scientifique; Francia. Centre Hospitalier Universitaire (CHU) Bordeaux; FranciaFil: Rascol, Olivier. Inserm; FranciaAmer Medical Assoc2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16126Perez Lloret, Santiago; Negre Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Paul; et al.; Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease; Amer Medical Assoc; JAMA Neurology; 71; 7; 7-2014; 884-8902168-61492168-6157enginfo:eu-repo/semantics/altIdentifier/doi/10.1001/jamaneurol.2014.753info:eu-repo/semantics/altIdentifier/url/http://jamanetwork.com/journals/jamaneurology/fullarticle/1871698info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:33Zoai:ri.conicet.gov.ar:11336/16126instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:33.485CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
title |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
spellingShingle |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease Perez Lloret, Santiago Parkinson disease Movement disorders Quality of life Medical Treatment |
title_short |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
title_full |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
title_fullStr |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
title_full_unstemmed |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
title_sort |
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease |
dc.creator.none.fl_str_mv |
Perez Lloret, Santiago Negre Pages, Laurence Damier, Philippe Delval, Arnaud Derkinderen, Paul Destée, Alain Meissner, Wassilios G. Schelosky, Ludwig Tison, Francois Rascol, Olivier |
author |
Perez Lloret, Santiago |
author_facet |
Perez Lloret, Santiago Negre Pages, Laurence Damier, Philippe Delval, Arnaud Derkinderen, Paul Destée, Alain Meissner, Wassilios G. Schelosky, Ludwig Tison, Francois Rascol, Olivier |
author_role |
author |
author2 |
Negre Pages, Laurence Damier, Philippe Delval, Arnaud Derkinderen, Paul Destée, Alain Meissner, Wassilios G. Schelosky, Ludwig Tison, Francois Rascol, Olivier |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Parkinson disease Movement disorders Quality of life Medical Treatment |
topic |
Parkinson disease Movement disorders Quality of life Medical Treatment |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
IMPORTANCE: Freezing of gait (FOG) is a common axial symptom of Parkinson disease (PD). OBJECTIVE: To determine the prevalence of FOG in a large group of PD patients, assess its relationship with quality of life and clinical and pharmacological factors, and explore its changes from the off to on conditions in patients with motor fluctuations. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional survey of 683 patients with idiopathic PD. Scores for FOG were missing in 11 patients who were not included in the analysis. Patients were recruited from referral centers and general neurology clinics in public or private institutions in France. EXPOSURE: Patients with FOG were identified as those with a score of 1 or greater on item 14 of the Unified Parkinson's Disease Rating Scale (UPDRS) in the on condition. Item 14 scores for FOG in the off condition were also collected in patients with fluctuating motor symptoms. MAIN OUTCOMES AND MEASURES: Quality of life (measured by the 39-item Parkinson's Disease Questionnaire and 36-Item Short Form Health Survey), anxiety and depression (Hospital Anxiety and Depression Scale), clinical features (UPDRS), and drug consumption. RESULTS: Of 672 PD patients, 257 reported FOG during the onstate (38.2%), which was significantly related to lower quality of life scores (P < .01). Freezing of gait was also correlated with longer PD duration (odds ratio, 1.92 [95% CI, 1.28-2.86]), higher UPDRS parts II and III scores (4.67 [3.21-6.78]), the presence of apathy (UPDRS item 4) (1.94 [1.33-2.82]), a higher levodopa equivalent daily dose (1.63 [1.09-2.43]), and more frequent exposure to antimuscarinics (3.07 [1.35-6.97]) (logistic regression). The FOG score improved from the off to on states in 148 of 174 patients with motor fluctuations (85.1%) and showed no change in 13.8%. The FOG score improved by more than 50% in 43.7% of patients. Greater improvement in the on state was observed in younger patients (r = -0.25; P < .01) with lower UPDRS II and III scores (r = -0.50; P < .01) and no antimuscarinic use (r = -0.21; P < .01). CONCLUSIONS AND RELEVANCE: Freezing of gait in PD patients correlates with poor quality of life, disease severity, apathy, and exposure to antimuscarinics. Dopaminergic therapy improved FOG in most patients with motor fluctuations, especially younger ones with less severe disease and no antimuscarinic use. This finding suggests that quality of life is impaired in PD patients with FOG and that optimizing dopaminergic therapy and avoiding antimuscarinics should be considered. Fil: Perez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. University of Toulouse; Argentina. Inserm; Francia Fil: Negre Pages, Laurence. LN Pharma; Francia Fil: Damier, Philippe. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Nantes; Francia Fil: Delval, Arnaud. Centre Hospitalier Universitaire (CHU) Lille; Francia Fil: Derkinderen, Paul. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Nantes; Francia Fil: Destée, Alain. Inserm; Francia. Centre Hospitalier Universitaire (CHU) Lille; Francia Fil: Meissner, Wassilios G.. Centre National de la Recherche Scientifique; Francia. Centre Hospitalier Universitaire (CHU) Bordeaux; Francia. Universite de Bordeaux; Francia Fil: Schelosky, Ludwig. Kantonsspital Münsterlingen; Suiza Fil: Tison, Francois. Universite de Bordeaux; Francia. Centre National de la Recherche Scientifique; Francia. Centre Hospitalier Universitaire (CHU) Bordeaux; Francia Fil: Rascol, Olivier. Inserm; Francia |
description |
IMPORTANCE: Freezing of gait (FOG) is a common axial symptom of Parkinson disease (PD). OBJECTIVE: To determine the prevalence of FOG in a large group of PD patients, assess its relationship with quality of life and clinical and pharmacological factors, and explore its changes from the off to on conditions in patients with motor fluctuations. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional survey of 683 patients with idiopathic PD. Scores for FOG were missing in 11 patients who were not included in the analysis. Patients were recruited from referral centers and general neurology clinics in public or private institutions in France. EXPOSURE: Patients with FOG were identified as those with a score of 1 or greater on item 14 of the Unified Parkinson's Disease Rating Scale (UPDRS) in the on condition. Item 14 scores for FOG in the off condition were also collected in patients with fluctuating motor symptoms. MAIN OUTCOMES AND MEASURES: Quality of life (measured by the 39-item Parkinson's Disease Questionnaire and 36-Item Short Form Health Survey), anxiety and depression (Hospital Anxiety and Depression Scale), clinical features (UPDRS), and drug consumption. RESULTS: Of 672 PD patients, 257 reported FOG during the onstate (38.2%), which was significantly related to lower quality of life scores (P < .01). Freezing of gait was also correlated with longer PD duration (odds ratio, 1.92 [95% CI, 1.28-2.86]), higher UPDRS parts II and III scores (4.67 [3.21-6.78]), the presence of apathy (UPDRS item 4) (1.94 [1.33-2.82]), a higher levodopa equivalent daily dose (1.63 [1.09-2.43]), and more frequent exposure to antimuscarinics (3.07 [1.35-6.97]) (logistic regression). The FOG score improved from the off to on states in 148 of 174 patients with motor fluctuations (85.1%) and showed no change in 13.8%. The FOG score improved by more than 50% in 43.7% of patients. Greater improvement in the on state was observed in younger patients (r = -0.25; P < .01) with lower UPDRS II and III scores (r = -0.50; P < .01) and no antimuscarinic use (r = -0.21; P < .01). CONCLUSIONS AND RELEVANCE: Freezing of gait in PD patients correlates with poor quality of life, disease severity, apathy, and exposure to antimuscarinics. Dopaminergic therapy improved FOG in most patients with motor fluctuations, especially younger ones with less severe disease and no antimuscarinic use. This finding suggests that quality of life is impaired in PD patients with FOG and that optimizing dopaminergic therapy and avoiding antimuscarinics should be considered. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/16126 Perez Lloret, Santiago; Negre Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Paul; et al.; Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease; Amer Medical Assoc; JAMA Neurology; 71; 7; 7-2014; 884-890 2168-6149 2168-6157 |
url |
http://hdl.handle.net/11336/16126 |
identifier_str_mv |
Perez Lloret, Santiago; Negre Pages, Laurence; Damier, Philippe; Delval, Arnaud; Derkinderen, Paul; et al.; Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease; Amer Medical Assoc; JAMA Neurology; 71; 7; 7-2014; 884-890 2168-6149 2168-6157 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1001/jamaneurol.2014.753 info:eu-repo/semantics/altIdentifier/url/http://jamanetwork.com/journals/jamaneurology/fullarticle/1871698 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Amer Medical Assoc |
publisher.none.fl_str_mv |
Amer Medical Assoc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614495799869440 |
score |
13.070432 |