Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves

Autores
Méndez Maldonado, Karla; Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Velasco, Iván
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The neural crest (NC) is a transient multipotent cell population that originates in the dorsal neural tube. Cells of the NC are highly migratory, as they travel considerable distances through the body to reach their final sites. Derivatives of the NC are neurons and glia of the peripheral nervous system (PNS) and the enteric nervous system as well as non-neural cells. Different signaling pathways triggered by Bone Morphogenetic Proteins (BMPs), Fibroblast Growth Factors (FGFs), Wnt proteins, Notch ligands, retinoic acid (RA), and Receptor Tyrosine Kinases (RTKs) participate in the processes of induction, specification, cell migration and neural differentiation of the NC. A specific set of signaling pathways and transcription factors are initially expressed in the neural plate border and then in the NC cell precursors to the formation of cranial nerves. The molecular mechanisms of control during embryonic development have been gradually elucidated, pointing to an important role of transcriptional regulators when neural differentiation occurs. However, some of these proteins have an important participation in malformations of the cranial portion and their mutation results in aberrant neurogenesis. This review aims to give an overview of the role of cell signaling and of the function of transcription factors involved in the specification of ganglia precursors and neurogenesis to form the NC-derived cranial nerves during organogenesis.
Fil: Méndez Maldonado, Karla. Universidad Nacional Autónoma de México; México
Fil: Vega López, Guillermo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Aybar, Manuel Javier. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Velasco, Iván. Universidad Nacional Autónoma de México; México
Materia
CELL SIGNALING
CRANIAL NERVE
FACIAL NERVE
HINDBRAIN
PERIPHERAL NERVOUS SYSTEM
TRANSCRIPTIONAL REGULATORY NETWORK
TRIGEMINAL NERVE
VAGUS NERVE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184042
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/184042
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nervesMéndez Maldonado, KarlaVega López, Guillermo AlfredoAybar, Manuel JavierVelasco, IvánCELL SIGNALINGCRANIAL NERVEFACIAL NERVEHINDBRAINPERIPHERAL NERVOUS SYSTEMTRANSCRIPTIONAL REGULATORY NETWORKTRIGEMINAL NERVEVAGUS NERVEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The neural crest (NC) is a transient multipotent cell population that originates in the dorsal neural tube. Cells of the NC are highly migratory, as they travel considerable distances through the body to reach their final sites. Derivatives of the NC are neurons and glia of the peripheral nervous system (PNS) and the enteric nervous system as well as non-neural cells. Different signaling pathways triggered by Bone Morphogenetic Proteins (BMPs), Fibroblast Growth Factors (FGFs), Wnt proteins, Notch ligands, retinoic acid (RA), and Receptor Tyrosine Kinases (RTKs) participate in the processes of induction, specification, cell migration and neural differentiation of the NC. A specific set of signaling pathways and transcription factors are initially expressed in the neural plate border and then in the NC cell precursors to the formation of cranial nerves. The molecular mechanisms of control during embryonic development have been gradually elucidated, pointing to an important role of transcriptional regulators when neural differentiation occurs. However, some of these proteins have an important participation in malformations of the cranial portion and their mutation results in aberrant neurogenesis. This review aims to give an overview of the role of cell signaling and of the function of transcription factors involved in the specification of ganglia precursors and neurogenesis to form the NC-derived cranial nerves during organogenesis.Fil: Méndez Maldonado, Karla. Universidad Nacional Autónoma de México; MéxicoFil: Vega López, Guillermo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Aybar, Manuel Javier. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Velasco, Iván. Universidad Nacional Autónoma de México; MéxicoFrontiers Media2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184042Méndez Maldonado, Karla; Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Velasco, Iván; Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves; Frontiers Media; Frontiers in Cell and Developmental Biology; 8; 8-2020; 1-262296-634XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2020.00635/info:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2020.00635info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:18Zoai:ri.conicet.gov.ar:11336/184042instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:19.076CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
title Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
spellingShingle Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
Méndez Maldonado, Karla
CELL SIGNALING
CRANIAL NERVE
FACIAL NERVE
HINDBRAIN
PERIPHERAL NERVOUS SYSTEM
TRANSCRIPTIONAL REGULATORY NETWORK
TRIGEMINAL NERVE
VAGUS NERVE
title_short Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
title_full Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
title_fullStr Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
title_full_unstemmed Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
title_sort Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves
dc.creator.none.fl_str_mv Méndez Maldonado, Karla
Vega López, Guillermo Alfredo
Aybar, Manuel Javier
Velasco, Iván
author Méndez Maldonado, Karla
author_facet Méndez Maldonado, Karla
Vega López, Guillermo Alfredo
Aybar, Manuel Javier
Velasco, Iván
author_role author
author2 Vega López, Guillermo Alfredo
Aybar, Manuel Javier
Velasco, Iván
author2_role author
author
author
dc.subject.none.fl_str_mv CELL SIGNALING
CRANIAL NERVE
FACIAL NERVE
HINDBRAIN
PERIPHERAL NERVOUS SYSTEM
TRANSCRIPTIONAL REGULATORY NETWORK
TRIGEMINAL NERVE
VAGUS NERVE
topic CELL SIGNALING
CRANIAL NERVE
FACIAL NERVE
HINDBRAIN
PERIPHERAL NERVOUS SYSTEM
TRANSCRIPTIONAL REGULATORY NETWORK
TRIGEMINAL NERVE
VAGUS NERVE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The neural crest (NC) is a transient multipotent cell population that originates in the dorsal neural tube. Cells of the NC are highly migratory, as they travel considerable distances through the body to reach their final sites. Derivatives of the NC are neurons and glia of the peripheral nervous system (PNS) and the enteric nervous system as well as non-neural cells. Different signaling pathways triggered by Bone Morphogenetic Proteins (BMPs), Fibroblast Growth Factors (FGFs), Wnt proteins, Notch ligands, retinoic acid (RA), and Receptor Tyrosine Kinases (RTKs) participate in the processes of induction, specification, cell migration and neural differentiation of the NC. A specific set of signaling pathways and transcription factors are initially expressed in the neural plate border and then in the NC cell precursors to the formation of cranial nerves. The molecular mechanisms of control during embryonic development have been gradually elucidated, pointing to an important role of transcriptional regulators when neural differentiation occurs. However, some of these proteins have an important participation in malformations of the cranial portion and their mutation results in aberrant neurogenesis. This review aims to give an overview of the role of cell signaling and of the function of transcription factors involved in the specification of ganglia precursors and neurogenesis to form the NC-derived cranial nerves during organogenesis.
Fil: Méndez Maldonado, Karla. Universidad Nacional Autónoma de México; México
Fil: Vega López, Guillermo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Aybar, Manuel Javier. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Velasco, Iván. Universidad Nacional Autónoma de México; México
description The neural crest (NC) is a transient multipotent cell population that originates in the dorsal neural tube. Cells of the NC are highly migratory, as they travel considerable distances through the body to reach their final sites. Derivatives of the NC are neurons and glia of the peripheral nervous system (PNS) and the enteric nervous system as well as non-neural cells. Different signaling pathways triggered by Bone Morphogenetic Proteins (BMPs), Fibroblast Growth Factors (FGFs), Wnt proteins, Notch ligands, retinoic acid (RA), and Receptor Tyrosine Kinases (RTKs) participate in the processes of induction, specification, cell migration and neural differentiation of the NC. A specific set of signaling pathways and transcription factors are initially expressed in the neural plate border and then in the NC cell precursors to the formation of cranial nerves. The molecular mechanisms of control during embryonic development have been gradually elucidated, pointing to an important role of transcriptional regulators when neural differentiation occurs. However, some of these proteins have an important participation in malformations of the cranial portion and their mutation results in aberrant neurogenesis. This review aims to give an overview of the role of cell signaling and of the function of transcription factors involved in the specification of ganglia precursors and neurogenesis to form the NC-derived cranial nerves during organogenesis.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184042
Méndez Maldonado, Karla; Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Velasco, Iván; Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves; Frontiers Media; Frontiers in Cell and Developmental Biology; 8; 8-2020; 1-26
2296-634X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184042
identifier_str_mv Méndez Maldonado, Karla; Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Velasco, Iván; Neurogenesis from neural crest cells: regulation and differentiation to produce cranial nerves; Frontiers Media; Frontiers in Cell and Developmental Biology; 8; 8-2020; 1-26
2296-634X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcell.2020.00635/
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcell.2020.00635
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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