The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis

Autores
Brandon, Mark Thomas; Bustos González, Liliana; Cascallares, Maria Guadalupe; Conejera, Felipe; Ewer, John
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The daily rhythm of adult emergence of holometabolous insects is one of the first circadian rhythms to be studied. In these insects, the circadian clock imposes a daily pattern of emergence by allowing or stimulating eclosion during certain windows of time and inhibiting emergence during others, a process that has been described as “gating.” Although the circadian rhythm of insect emergence provided many of the key concepts of chronobiology, little progress has been made in understanding the bases of the gating process itself, although the term “gating” suggests that it is separate from the developmental process of metamorphosis. Here, we follow the progression through the final stages of Drosophila adult development with single-animal resolution and show that the circadian clock imposes a daily rhythmicity to the pattern of emergence by controlling when the insect initiates the final steps of metamorphosis itself. Circadian rhythmicity of emergence depends on the coupling between the central clock located in the brain and a peripheral clock located in the prothoracic gland (PG), an endocrine gland whose only known function is the production of the molting hormone, ecdysone. Here, we show that the clock exerts its action by regulating not the levels of ecdysone but that of its actions mediated by the ecdysone receptor. Our findings may also provide insights for understanding the mechanisms by which the daily rhythms of glucocorticoids are produced in mammals, which result from the coupling between the central clock in the suprachiasmatic nucleus and a peripheral clock located in the suprarenal gland.
Fil: Brandon, Mark Thomas. Universidad de Valparaíso; Chile. University of Washington; Estados Unidos
Fil: Bustos González, Liliana. Universidad de Valparaíso; Chile
Fil: Cascallares, Maria Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Subsede Instituto Nacional de Investigación y Desarrollo Pesquero; Argentina. Universidad de Valparaíso; Chile
Fil: Conejera, Felipe. Universidad de Valparaíso; Chile
Fil: Ewer, John. Universidad de Valparaíso; Chile
Materia
ADULT ECDYSIS
ECDYSONE ACTION
ECLOSION
INSECT EMERGENCE
METAMORPHOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167582
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosisBrandon, Mark ThomasBustos González, LilianaCascallares, Maria GuadalupeConejera, FelipeEwer, JohnADULT ECDYSISECDYSONE ACTIONECLOSIONINSECT EMERGENCEMETAMORPHOSIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The daily rhythm of adult emergence of holometabolous insects is one of the first circadian rhythms to be studied. In these insects, the circadian clock imposes a daily pattern of emergence by allowing or stimulating eclosion during certain windows of time and inhibiting emergence during others, a process that has been described as “gating.” Although the circadian rhythm of insect emergence provided many of the key concepts of chronobiology, little progress has been made in understanding the bases of the gating process itself, although the term “gating” suggests that it is separate from the developmental process of metamorphosis. Here, we follow the progression through the final stages of Drosophila adult development with single-animal resolution and show that the circadian clock imposes a daily rhythmicity to the pattern of emergence by controlling when the insect initiates the final steps of metamorphosis itself. Circadian rhythmicity of emergence depends on the coupling between the central clock located in the brain and a peripheral clock located in the prothoracic gland (PG), an endocrine gland whose only known function is the production of the molting hormone, ecdysone. Here, we show that the clock exerts its action by regulating not the levels of ecdysone but that of its actions mediated by the ecdysone receptor. Our findings may also provide insights for understanding the mechanisms by which the daily rhythms of glucocorticoids are produced in mammals, which result from the coupling between the central clock in the suprachiasmatic nucleus and a peripheral clock located in the suprarenal gland.Fil: Brandon, Mark Thomas. Universidad de Valparaíso; Chile. University of Washington; Estados UnidosFil: Bustos González, Liliana. Universidad de Valparaíso; ChileFil: Cascallares, Maria Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Subsede Instituto Nacional de Investigación y Desarrollo Pesquero; Argentina. Universidad de Valparaíso; ChileFil: Conejera, Felipe. Universidad de Valparaíso; ChileFil: Ewer, John. Universidad de Valparaíso; ChileNational Academy of Sciences2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167582Brandon, Mark Thomas; Bustos González, Liliana; Cascallares, Maria Guadalupe; Conejera, Felipe; Ewer, John; The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 118; 27; 7-2021; 1-100027-84241091-6490CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2023249118info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/full/10.1073/pnas.2023249118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:02Zoai:ri.conicet.gov.ar:11336/167582instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:02.77CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
title The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
spellingShingle The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
Brandon, Mark Thomas
ADULT ECDYSIS
ECDYSONE ACTION
ECLOSION
INSECT EMERGENCE
METAMORPHOSIS
title_short The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
title_full The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
title_fullStr The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
title_full_unstemmed The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
title_sort The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis
dc.creator.none.fl_str_mv Brandon, Mark Thomas
Bustos González, Liliana
Cascallares, Maria Guadalupe
Conejera, Felipe
Ewer, John
author Brandon, Mark Thomas
author_facet Brandon, Mark Thomas
Bustos González, Liliana
Cascallares, Maria Guadalupe
Conejera, Felipe
Ewer, John
author_role author
author2 Bustos González, Liliana
Cascallares, Maria Guadalupe
Conejera, Felipe
Ewer, John
author2_role author
author
author
author
dc.subject.none.fl_str_mv ADULT ECDYSIS
ECDYSONE ACTION
ECLOSION
INSECT EMERGENCE
METAMORPHOSIS
topic ADULT ECDYSIS
ECDYSONE ACTION
ECLOSION
INSECT EMERGENCE
METAMORPHOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The daily rhythm of adult emergence of holometabolous insects is one of the first circadian rhythms to be studied. In these insects, the circadian clock imposes a daily pattern of emergence by allowing or stimulating eclosion during certain windows of time and inhibiting emergence during others, a process that has been described as “gating.” Although the circadian rhythm of insect emergence provided many of the key concepts of chronobiology, little progress has been made in understanding the bases of the gating process itself, although the term “gating” suggests that it is separate from the developmental process of metamorphosis. Here, we follow the progression through the final stages of Drosophila adult development with single-animal resolution and show that the circadian clock imposes a daily rhythmicity to the pattern of emergence by controlling when the insect initiates the final steps of metamorphosis itself. Circadian rhythmicity of emergence depends on the coupling between the central clock located in the brain and a peripheral clock located in the prothoracic gland (PG), an endocrine gland whose only known function is the production of the molting hormone, ecdysone. Here, we show that the clock exerts its action by regulating not the levels of ecdysone but that of its actions mediated by the ecdysone receptor. Our findings may also provide insights for understanding the mechanisms by which the daily rhythms of glucocorticoids are produced in mammals, which result from the coupling between the central clock in the suprachiasmatic nucleus and a peripheral clock located in the suprarenal gland.
Fil: Brandon, Mark Thomas. Universidad de Valparaíso; Chile. University of Washington; Estados Unidos
Fil: Bustos González, Liliana. Universidad de Valparaíso; Chile
Fil: Cascallares, Maria Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Subsede Instituto Nacional de Investigación y Desarrollo Pesquero; Argentina. Universidad de Valparaíso; Chile
Fil: Conejera, Felipe. Universidad de Valparaíso; Chile
Fil: Ewer, John. Universidad de Valparaíso; Chile
description The daily rhythm of adult emergence of holometabolous insects is one of the first circadian rhythms to be studied. In these insects, the circadian clock imposes a daily pattern of emergence by allowing or stimulating eclosion during certain windows of time and inhibiting emergence during others, a process that has been described as “gating.” Although the circadian rhythm of insect emergence provided many of the key concepts of chronobiology, little progress has been made in understanding the bases of the gating process itself, although the term “gating” suggests that it is separate from the developmental process of metamorphosis. Here, we follow the progression through the final stages of Drosophila adult development with single-animal resolution and show that the circadian clock imposes a daily rhythmicity to the pattern of emergence by controlling when the insect initiates the final steps of metamorphosis itself. Circadian rhythmicity of emergence depends on the coupling between the central clock located in the brain and a peripheral clock located in the prothoracic gland (PG), an endocrine gland whose only known function is the production of the molting hormone, ecdysone. Here, we show that the clock exerts its action by regulating not the levels of ecdysone but that of its actions mediated by the ecdysone receptor. Our findings may also provide insights for understanding the mechanisms by which the daily rhythms of glucocorticoids are produced in mammals, which result from the coupling between the central clock in the suprachiasmatic nucleus and a peripheral clock located in the suprarenal gland.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167582
Brandon, Mark Thomas; Bustos González, Liliana; Cascallares, Maria Guadalupe; Conejera, Felipe; Ewer, John; The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 118; 27; 7-2021; 1-10
0027-8424
1091-6490
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167582
identifier_str_mv Brandon, Mark Thomas; Bustos González, Liliana; Cascallares, Maria Guadalupe; Conejera, Felipe; Ewer, John; The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 118; 27; 7-2021; 1-10
0027-8424
1091-6490
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2023249118
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/full/10.1073/pnas.2023249118
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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