Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry

Autores
Limandri, Silvina Paola; Visñovezky, Claudia Analía; Pérez, Silvina C.; Schurrer, Clemar Aldino; Wolfenson, Alberto Enrique; Ferro, Maribel; Cuffini, Silvia Lucia; Gonçalves de Souza, Joel; Aguiar, F. Armani; Masetto de Gaitani, C.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pharmaceuticals can exist in many solid forms, which can have different physical and chemical properties. These solid forms include polymorphs, solvates, amorphous, and hydrates. Particularly, hydration process can be quite common since pharmaceutical solids can be in contact with water during manufacturing process and can also be exposed to water during storage. In the present work, it is proved that NQR technique is capable of detecting different hydrated forms not only in the pure raw material but also in the final product (tablets), being in this way a useful technique for quality control. This technique was also used to study the dehydration process from pentahydrate to trihydrate.
Fil: Limandri, Silvina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Visñovezky, Claudia Analía. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Pérez, Silvina C.. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Schurrer, Clemar Aldino. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Wolfenson, Alberto Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Ferro, Maribel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
Fil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Gonçalves de Souza, Joel. Universidade de Sao Paulo; Brasil
Fil: Aguiar, F. Armani. Universidade de Sao Paulo; Brasil
Fil: Masetto de Gaitani, C.. Universidade de Sao Paulo; Brasil
Materia
NUCLEAR QUADRUPOLE RESONANCE
HYDRATATION PROCESSES
PHARMACEUTICALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268446
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical IndustryLimandri, Silvina PaolaVisñovezky, Claudia AnalíaPérez, Silvina C.Schurrer, Clemar AldinoWolfenson, Alberto EnriqueFerro, MaribelCuffini, Silvia LuciaGonçalves de Souza, JoelAguiar, F. ArmaniMasetto de Gaitani, C.NUCLEAR QUADRUPOLE RESONANCEHYDRATATION PROCESSESPHARMACEUTICALShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Pharmaceuticals can exist in many solid forms, which can have different physical and chemical properties. These solid forms include polymorphs, solvates, amorphous, and hydrates. Particularly, hydration process can be quite common since pharmaceutical solids can be in contact with water during manufacturing process and can also be exposed to water during storage. In the present work, it is proved that NQR technique is capable of detecting different hydrated forms not only in the pure raw material but also in the final product (tablets), being in this way a useful technique for quality control. This technique was also used to study the dehydration process from pentahydrate to trihydrate.Fil: Limandri, Silvina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Visñovezky, Claudia Analía. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Pérez, Silvina C.. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Schurrer, Clemar Aldino. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Wolfenson, Alberto Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Ferro, Maribel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; ArgentinaFil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Gonçalves de Souza, Joel. Universidade de Sao Paulo; BrasilFil: Aguiar, F. Armani. Universidade de Sao Paulo; BrasilFil: Masetto de Gaitani, C.. Universidade de Sao Paulo; BrasilAmerican Chemical Society2011-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268446Limandri, Silvina Paola; Visñovezky, Claudia Analía; Pérez, Silvina C.; Schurrer, Clemar Aldino; Wolfenson, Alberto Enrique; et al.; Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry; American Chemical Society; Analytical Chemistry; 83; 5; 2-2011; 1773-17760003-2700CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/ac103106yinfo:eu-repo/semantics/altIdentifier/doi/10.1021/ac103106yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:20Zoai:ri.conicet.gov.ar:11336/268446instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:21.214CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
title Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
spellingShingle Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
Limandri, Silvina Paola
NUCLEAR QUADRUPOLE RESONANCE
HYDRATATION PROCESSES
PHARMACEUTICALS
title_short Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
title_full Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
title_fullStr Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
title_full_unstemmed Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
title_sort Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
dc.creator.none.fl_str_mv Limandri, Silvina Paola
Visñovezky, Claudia Analía
Pérez, Silvina C.
Schurrer, Clemar Aldino
Wolfenson, Alberto Enrique
Ferro, Maribel
Cuffini, Silvia Lucia
Gonçalves de Souza, Joel
Aguiar, F. Armani
Masetto de Gaitani, C.
author Limandri, Silvina Paola
author_facet Limandri, Silvina Paola
Visñovezky, Claudia Analía
Pérez, Silvina C.
Schurrer, Clemar Aldino
Wolfenson, Alberto Enrique
Ferro, Maribel
Cuffini, Silvia Lucia
Gonçalves de Souza, Joel
Aguiar, F. Armani
Masetto de Gaitani, C.
author_role author
author2 Visñovezky, Claudia Analía
Pérez, Silvina C.
Schurrer, Clemar Aldino
Wolfenson, Alberto Enrique
Ferro, Maribel
Cuffini, Silvia Lucia
Gonçalves de Souza, Joel
Aguiar, F. Armani
Masetto de Gaitani, C.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NUCLEAR QUADRUPOLE RESONANCE
HYDRATATION PROCESSES
PHARMACEUTICALS
topic NUCLEAR QUADRUPOLE RESONANCE
HYDRATATION PROCESSES
PHARMACEUTICALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pharmaceuticals can exist in many solid forms, which can have different physical and chemical properties. These solid forms include polymorphs, solvates, amorphous, and hydrates. Particularly, hydration process can be quite common since pharmaceutical solids can be in contact with water during manufacturing process and can also be exposed to water during storage. In the present work, it is proved that NQR technique is capable of detecting different hydrated forms not only in the pure raw material but also in the final product (tablets), being in this way a useful technique for quality control. This technique was also used to study the dehydration process from pentahydrate to trihydrate.
Fil: Limandri, Silvina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Visñovezky, Claudia Analía. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Pérez, Silvina C.. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Schurrer, Clemar Aldino. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Wolfenson, Alberto Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Ferro, Maribel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
Fil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Gonçalves de Souza, Joel. Universidade de Sao Paulo; Brasil
Fil: Aguiar, F. Armani. Universidade de Sao Paulo; Brasil
Fil: Masetto de Gaitani, C.. Universidade de Sao Paulo; Brasil
description Pharmaceuticals can exist in many solid forms, which can have different physical and chemical properties. These solid forms include polymorphs, solvates, amorphous, and hydrates. Particularly, hydration process can be quite common since pharmaceutical solids can be in contact with water during manufacturing process and can also be exposed to water during storage. In the present work, it is proved that NQR technique is capable of detecting different hydrated forms not only in the pure raw material but also in the final product (tablets), being in this way a useful technique for quality control. This technique was also used to study the dehydration process from pentahydrate to trihydrate.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268446
Limandri, Silvina Paola; Visñovezky, Claudia Analía; Pérez, Silvina C.; Schurrer, Clemar Aldino; Wolfenson, Alberto Enrique; et al.; Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry; American Chemical Society; Analytical Chemistry; 83; 5; 2-2011; 1773-1776
0003-2700
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268446
identifier_str_mv Limandri, Silvina Paola; Visñovezky, Claudia Analía; Pérez, Silvina C.; Schurrer, Clemar Aldino; Wolfenson, Alberto Enrique; et al.; Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry; American Chemical Society; Analytical Chemistry; 83; 5; 2-2011; 1773-1776
0003-2700
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/ac103106y
info:eu-repo/semantics/altIdentifier/doi/10.1021/ac103106y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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