Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus

Autores
Sartori, César Renato; Pelágio, Fernanda Campos; Teixeira, Simone Aparecida; Valentinuzzi, Verónica Sandra; Nascimento, André Luiz; Rogério, Fábio; Muscará, Marcelo Nicolás; Ferrari, Elenice Aparecida de Moraes; Langone, Francesco
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Voluntary physical activity improves memory and learning ability in rodents, whereas status epilepticus has been associated with memory impairment. Physical activity and seizures have been associated with enhanced hippocampal expression of BDNF, indicating that this protein may have a dual role in epilepsy. The influence of voluntary physical activity on memory and BDNF expression has been poorly studied in experimental models of epilepsy. In this paper, we have investigated the effect of voluntary physical activity on memory and BDNF expression in mice with pilocarpine-induced epilepsy. Male Swiss mice were assigned to four experimental groups: pilocarpine sedentary (PS), pilocarpine runners (PRs), saline sedentary (SS) and saline runners (SRs). Two days after pilocarpine-induced status epilepticus, the affected mice (PR) and their running controls (SR) were housed with access to a running wheel for 28 days. After that, the spatial memory and the expression of the precursor and mature forms of hippocampal BDNF were assessed. PR mice performed better than PS mice in the water maze test. In addition, PR mice had a higher amount of mature BDNF (14 kDa) relative to the total BDNF (14 kDa + 28 kDa + 32 kDa forms) content when compared with PS mice. These results show that voluntary physical activity improved the spatial memory and increased the hippocampal content of mature BDNF of mice with pilocarpine-induced status epilepticus,
Fil: Sartori, César Renato. Universidade Estadual de Campinas; Brasil
Fil: Pelágio, Fernanda Campos. Universidade Estadual de Campinas; Brasil
Fil: Teixeira, Simone Aparecida. Universidade de Sao Paulo; Brasil
Fil: Valentinuzzi, Verónica Sandra. Universidade Estadual de Campinas; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Secretaría de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; Argentina
Fil: Nascimento, André Luiz. Universidade Estadual de Campinas; Brasil
Fil: Rogério, Fábio. Universidade Estadual de Campinas; Brasil
Fil: Muscará, Marcelo Nicolás. Universidade de Sao Paulo; Brasil
Fil: Ferrari, Elenice Aparecida de Moraes. Universidade Estadual de Campinas; Brasil
Fil: Langone, Francesco. Universidade Estadual de Campinas; Brasil
Materia
Bdnf
Epilepsy
Exercise
Mice
Physical Activity
Pilocarpine
Spatial Memory
Water Maze
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81030
Acceder
id CONICETDig_6748bf7852f5a0ce3efb7b6c8aaf1deb
oai_identifier_str oai:ri.conicet.gov.ar:11336/81030
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticusSartori, César RenatoPelágio, Fernanda CamposTeixeira, Simone AparecidaValentinuzzi, Verónica SandraNascimento, André LuizRogério, FábioMuscará, Marcelo NicolásFerrari, Elenice Aparecida de MoraesLangone, FrancescoBdnfEpilepsyExerciseMicePhysical ActivityPilocarpineSpatial MemoryWater Mazehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Voluntary physical activity improves memory and learning ability in rodents, whereas status epilepticus has been associated with memory impairment. Physical activity and seizures have been associated with enhanced hippocampal expression of BDNF, indicating that this protein may have a dual role in epilepsy. The influence of voluntary physical activity on memory and BDNF expression has been poorly studied in experimental models of epilepsy. In this paper, we have investigated the effect of voluntary physical activity on memory and BDNF expression in mice with pilocarpine-induced epilepsy. Male Swiss mice were assigned to four experimental groups: pilocarpine sedentary (PS), pilocarpine runners (PRs), saline sedentary (SS) and saline runners (SRs). Two days after pilocarpine-induced status epilepticus, the affected mice (PR) and their running controls (SR) were housed with access to a running wheel for 28 days. After that, the spatial memory and the expression of the precursor and mature forms of hippocampal BDNF were assessed. PR mice performed better than PS mice in the water maze test. In addition, PR mice had a higher amount of mature BDNF (14 kDa) relative to the total BDNF (14 kDa + 28 kDa + 32 kDa forms) content when compared with PS mice. These results show that voluntary physical activity improved the spatial memory and increased the hippocampal content of mature BDNF of mice with pilocarpine-induced status epilepticus,Fil: Sartori, César Renato. Universidade Estadual de Campinas; BrasilFil: Pelágio, Fernanda Campos. Universidade Estadual de Campinas; BrasilFil: Teixeira, Simone Aparecida. Universidade de Sao Paulo; BrasilFil: Valentinuzzi, Verónica Sandra. Universidade Estadual de Campinas; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Secretaría de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; ArgentinaFil: Nascimento, André Luiz. Universidade Estadual de Campinas; BrasilFil: Rogério, Fábio. Universidade Estadual de Campinas; BrasilFil: Muscará, Marcelo Nicolás. Universidade de Sao Paulo; BrasilFil: Ferrari, Elenice Aparecida de Moraes. Universidade Estadual de Campinas; BrasilFil: Langone, Francesco. Universidade Estadual de Campinas; BrasilElsevier Science2009-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81030Sartori, César Renato; Pelágio, Fernanda Campos; Teixeira, Simone Aparecida; Valentinuzzi, Verónica Sandra; Nascimento, André Luiz; et al.; Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus; Elsevier Science; Behavioural Brain Research; 203; 2; 11-2009; 165-1720166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432809002575info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2009.04.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:20:34Zoai:ri.conicet.gov.ar:11336/81030instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:20:35.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
title Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
spellingShingle Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
Sartori, César Renato
Bdnf
Epilepsy
Exercise
Mice
Physical Activity
Pilocarpine
Spatial Memory
Water Maze
title_short Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
title_full Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
title_fullStr Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
title_full_unstemmed Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
title_sort Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
dc.creator.none.fl_str_mv Sartori, César Renato
Pelágio, Fernanda Campos
Teixeira, Simone Aparecida
Valentinuzzi, Verónica Sandra
Nascimento, André Luiz
Rogério, Fábio
Muscará, Marcelo Nicolás
Ferrari, Elenice Aparecida de Moraes
Langone, Francesco
author Sartori, César Renato
author_facet Sartori, César Renato
Pelágio, Fernanda Campos
Teixeira, Simone Aparecida
Valentinuzzi, Verónica Sandra
Nascimento, André Luiz
Rogério, Fábio
Muscará, Marcelo Nicolás
Ferrari, Elenice Aparecida de Moraes
Langone, Francesco
author_role author
author2 Pelágio, Fernanda Campos
Teixeira, Simone Aparecida
Valentinuzzi, Verónica Sandra
Nascimento, André Luiz
Rogério, Fábio
Muscará, Marcelo Nicolás
Ferrari, Elenice Aparecida de Moraes
Langone, Francesco
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bdnf
Epilepsy
Exercise
Mice
Physical Activity
Pilocarpine
Spatial Memory
Water Maze
topic Bdnf
Epilepsy
Exercise
Mice
Physical Activity
Pilocarpine
Spatial Memory
Water Maze
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Voluntary physical activity improves memory and learning ability in rodents, whereas status epilepticus has been associated with memory impairment. Physical activity and seizures have been associated with enhanced hippocampal expression of BDNF, indicating that this protein may have a dual role in epilepsy. The influence of voluntary physical activity on memory and BDNF expression has been poorly studied in experimental models of epilepsy. In this paper, we have investigated the effect of voluntary physical activity on memory and BDNF expression in mice with pilocarpine-induced epilepsy. Male Swiss mice were assigned to four experimental groups: pilocarpine sedentary (PS), pilocarpine runners (PRs), saline sedentary (SS) and saline runners (SRs). Two days after pilocarpine-induced status epilepticus, the affected mice (PR) and their running controls (SR) were housed with access to a running wheel for 28 days. After that, the spatial memory and the expression of the precursor and mature forms of hippocampal BDNF were assessed. PR mice performed better than PS mice in the water maze test. In addition, PR mice had a higher amount of mature BDNF (14 kDa) relative to the total BDNF (14 kDa + 28 kDa + 32 kDa forms) content when compared with PS mice. These results show that voluntary physical activity improved the spatial memory and increased the hippocampal content of mature BDNF of mice with pilocarpine-induced status epilepticus,
Fil: Sartori, César Renato. Universidade Estadual de Campinas; Brasil
Fil: Pelágio, Fernanda Campos. Universidade Estadual de Campinas; Brasil
Fil: Teixeira, Simone Aparecida. Universidade de Sao Paulo; Brasil
Fil: Valentinuzzi, Verónica Sandra. Universidade Estadual de Campinas; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Secretaría de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; Argentina
Fil: Nascimento, André Luiz. Universidade Estadual de Campinas; Brasil
Fil: Rogério, Fábio. Universidade Estadual de Campinas; Brasil
Fil: Muscará, Marcelo Nicolás. Universidade de Sao Paulo; Brasil
Fil: Ferrari, Elenice Aparecida de Moraes. Universidade Estadual de Campinas; Brasil
Fil: Langone, Francesco. Universidade Estadual de Campinas; Brasil
description Voluntary physical activity improves memory and learning ability in rodents, whereas status epilepticus has been associated with memory impairment. Physical activity and seizures have been associated with enhanced hippocampal expression of BDNF, indicating that this protein may have a dual role in epilepsy. The influence of voluntary physical activity on memory and BDNF expression has been poorly studied in experimental models of epilepsy. In this paper, we have investigated the effect of voluntary physical activity on memory and BDNF expression in mice with pilocarpine-induced epilepsy. Male Swiss mice were assigned to four experimental groups: pilocarpine sedentary (PS), pilocarpine runners (PRs), saline sedentary (SS) and saline runners (SRs). Two days after pilocarpine-induced status epilepticus, the affected mice (PR) and their running controls (SR) were housed with access to a running wheel for 28 days. After that, the spatial memory and the expression of the precursor and mature forms of hippocampal BDNF were assessed. PR mice performed better than PS mice in the water maze test. In addition, PR mice had a higher amount of mature BDNF (14 kDa) relative to the total BDNF (14 kDa + 28 kDa + 32 kDa forms) content when compared with PS mice. These results show that voluntary physical activity improved the spatial memory and increased the hippocampal content of mature BDNF of mice with pilocarpine-induced status epilepticus,
publishDate 2009
dc.date.none.fl_str_mv 2009-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81030
Sartori, César Renato; Pelágio, Fernanda Campos; Teixeira, Simone Aparecida; Valentinuzzi, Verónica Sandra; Nascimento, André Luiz; et al.; Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus; Elsevier Science; Behavioural Brain Research; 203; 2; 11-2009; 165-172
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81030
identifier_str_mv Sartori, César Renato; Pelágio, Fernanda Campos; Teixeira, Simone Aparecida; Valentinuzzi, Verónica Sandra; Nascimento, André Luiz; et al.; Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus; Elsevier Science; Behavioural Brain Research; 203; 2; 11-2009; 165-172
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432809002575
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2009.04.022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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