Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages
- Autores
- Souriant, Shanti; Balboa, Luciana; Dupont, Maeva; Pingris, Karine; Kviatcovsky, Denise; Cougoule, Céline; Lastrucci, Claire; Bah, Aicha; Gasser, Romain; Poincloux, Renaud; Raynaud Messina, Brigitte; Al Saati, Talal; Inwentarz, Sandra; Poggi, Susana; Moraña, Eduardo Jose; González Montaner, Pablo; Corti, Marcelo; Lagane, Bernard; Vergne, Isabelle; Allers, Carolina; Kaushal, Deepak; Kuroda, Marcelo J.; Sasiain, Maria del Carmen; Neyrolles, Olivier; Maridonneau Parini, Isabelle; Lugo Villarino, Geanncarlo; Vérollet, Christel
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present in TB-associated microenvironment, produce high levels of HIV-1. In vivo, M(IL-10) macrophages are expanded in lungs of co-infected non-human primates, which correlates with disease severity. Furthermore, HIV-1/Mtb co-infected patients display an accumulation of M(IL-10) macrophage markers (soluble CD163 and MerTK). These M(IL-10) macrophages form direct cell-to-cell bridges, which we identified as tunneling nanotubes (TNTs) involved in viral transfer. TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages. Our study reveals that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics. Tuberculosis is a clear, yet confounding, risk factor for HIV-1-induced morbidity and mortality. In this issue, Souriant et al. reveal that a tuberculosis-associated microenvironment triggers IL-10/STAT3-dependent tunneling nanotube formation in M(IL-10) macrophages, which promotes HIV-1 exacerbation during co-infection. M(IL-10) macrophage accumulation is also observed in vivo in co-infected subjects.
Fil: Souriant, Shanti. Université Paul Sabatier; Francia
Fil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Dupont, Maeva. Centre National de la Recherche Scientifique; Francia
Fil: Pingris, Karine. Centre National de la Recherche Scientifique; Francia
Fil: Kviatcovsky, Denise. Centre National de la Recherche Scientifique; Francia
Fil: Cougoule, Céline. Centre National de la Recherche Scientifique; Francia
Fil: Lastrucci, Claire. Centro de Regulación Genómica; España
Fil: Bah, Aicha. Université Paul Sabatier; Francia
Fil: Gasser, Romain. Centre National de la Recherche Scientifique; Francia
Fil: Poincloux, Renaud. Centre National de la Recherche Scientifique; Francia
Fil: Raynaud Messina, Brigitte. Université de Toulouse; Francia
Fil: Al Saati, Talal. Centro de Regulación Genómica; España
Fil: Inwentarz, Sandra. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: Poggi, Susana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: Moraña, Eduardo Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: González Montaner, Pablo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: Corti, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Lagane, Bernard. Université Paul Sabatier; Francia
Fil: Vergne, Isabelle. Centre National de la Recherche Scientifique; Francia
Fil: Allers, Carolina. University of Tulane; Estados Unidos
Fil: Kaushal, Deepak. University of Tulane; Estados Unidos
Fil: Kuroda, Marcelo J.. University of Tulane; Estados Unidos
Fil: Sasiain, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Neyrolles, Olivier. Centre National de la Recherche Scientifique; Francia
Fil: Maridonneau Parini, Isabelle. Université de Toulouse; ; Francia
Fil: Lugo Villarino, Geanncarlo. No especifíca;
Fil: Vérollet, Christel. Centre National de la Recherche Scientifique; Francia - Materia
-
AIDS
BIOMARKER
CO-INFECTION
HIV-1
IL-10
MACROPHAGE
MONOCYTE
MYCOBACTERIUM TUBERCULOSIS
STAT3
TUBERCULOSIS
TUNNELING NANOTUBES
VIRAL SPREAD - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/183500
Ver los metadatos del registro completo
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Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in MacrophagesSouriant, ShantiBalboa, LucianaDupont, MaevaPingris, KarineKviatcovsky, DeniseCougoule, CélineLastrucci, ClaireBah, AichaGasser, RomainPoincloux, RenaudRaynaud Messina, BrigitteAl Saati, TalalInwentarz, SandraPoggi, SusanaMoraña, Eduardo JoseGonzález Montaner, PabloCorti, MarceloLagane, BernardVergne, IsabelleAllers, CarolinaKaushal, DeepakKuroda, Marcelo J.Sasiain, Maria del CarmenNeyrolles, OlivierMaridonneau Parini, IsabelleLugo Villarino, GeanncarloVérollet, ChristelAIDSBIOMARKERCO-INFECTIONHIV-1IL-10MACROPHAGEMONOCYTEMYCOBACTERIUM TUBERCULOSISSTAT3TUBERCULOSISTUNNELING NANOTUBESVIRAL SPREADhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present in TB-associated microenvironment, produce high levels of HIV-1. In vivo, M(IL-10) macrophages are expanded in lungs of co-infected non-human primates, which correlates with disease severity. Furthermore, HIV-1/Mtb co-infected patients display an accumulation of M(IL-10) macrophage markers (soluble CD163 and MerTK). These M(IL-10) macrophages form direct cell-to-cell bridges, which we identified as tunneling nanotubes (TNTs) involved in viral transfer. TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages. Our study reveals that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics. Tuberculosis is a clear, yet confounding, risk factor for HIV-1-induced morbidity and mortality. In this issue, Souriant et al. reveal that a tuberculosis-associated microenvironment triggers IL-10/STAT3-dependent tunneling nanotube formation in M(IL-10) macrophages, which promotes HIV-1 exacerbation during co-infection. M(IL-10) macrophage accumulation is also observed in vivo in co-infected subjects.Fil: Souriant, Shanti. Université Paul Sabatier; FranciaFil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Dupont, Maeva. Centre National de la Recherche Scientifique; FranciaFil: Pingris, Karine. Centre National de la Recherche Scientifique; FranciaFil: Kviatcovsky, Denise. Centre National de la Recherche Scientifique; FranciaFil: Cougoule, Céline. Centre National de la Recherche Scientifique; FranciaFil: Lastrucci, Claire. Centro de Regulación Genómica; EspañaFil: Bah, Aicha. Université Paul Sabatier; FranciaFil: Gasser, Romain. Centre National de la Recherche Scientifique; FranciaFil: Poincloux, Renaud. Centre National de la Recherche Scientifique; FranciaFil: Raynaud Messina, Brigitte. Université de Toulouse; FranciaFil: Al Saati, Talal. Centro de Regulación Genómica; EspañaFil: Inwentarz, Sandra. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; ArgentinaFil: Poggi, Susana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; ArgentinaFil: Moraña, Eduardo Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; ArgentinaFil: González Montaner, Pablo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; ArgentinaFil: Corti, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Lagane, Bernard. Université Paul Sabatier; FranciaFil: Vergne, Isabelle. Centre National de la Recherche Scientifique; FranciaFil: Allers, Carolina. University of Tulane; Estados UnidosFil: Kaushal, Deepak. University of Tulane; Estados UnidosFil: Kuroda, Marcelo J.. University of Tulane; Estados UnidosFil: Sasiain, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Neyrolles, Olivier. Centre National de la Recherche Scientifique; FranciaFil: Maridonneau Parini, Isabelle. Université de Toulouse; ; FranciaFil: Lugo Villarino, Geanncarlo. No especifíca;Fil: Vérollet, Christel. Centre National de la Recherche Scientifique; FranciaElsevier2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/183500Souriant, Shanti; Balboa, Luciana; Dupont, Maeva; Pingris, Karine; Kviatcovsky, Denise; et al.; Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages; Elsevier; Cell Reports; 26; 13; 3-2019; 3586-3599.e72211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/url/https://ri.conicet.gov.ar/admin/retrieve/c4a7dd62-7247-424b-9f38-5d47f507b999/CONICET_Digital_Nro.72b81aa2-765a-4413-8fb4-74ba5081b044_D.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2019.02.091info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/admin/retrieve/4657a939-dd0f-4d93-9ccf-3dc1c491cd6e/CONICET_Digital_Nro.72b81aa2-765a-4413-8fb4-74ba5081b044_A.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:22Zoai:ri.conicet.gov.ar:11336/183500instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:23.527CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| title |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| spellingShingle |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages Souriant, Shanti AIDS BIOMARKER CO-INFECTION HIV-1 IL-10 MACROPHAGE MONOCYTE MYCOBACTERIUM TUBERCULOSIS STAT3 TUBERCULOSIS TUNNELING NANOTUBES VIRAL SPREAD |
| title_short |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| title_full |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| title_fullStr |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| title_full_unstemmed |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| title_sort |
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages |
| dc.creator.none.fl_str_mv |
Souriant, Shanti Balboa, Luciana Dupont, Maeva Pingris, Karine Kviatcovsky, Denise Cougoule, Céline Lastrucci, Claire Bah, Aicha Gasser, Romain Poincloux, Renaud Raynaud Messina, Brigitte Al Saati, Talal Inwentarz, Sandra Poggi, Susana Moraña, Eduardo Jose González Montaner, Pablo Corti, Marcelo Lagane, Bernard Vergne, Isabelle Allers, Carolina Kaushal, Deepak Kuroda, Marcelo J. Sasiain, Maria del Carmen Neyrolles, Olivier Maridonneau Parini, Isabelle Lugo Villarino, Geanncarlo Vérollet, Christel |
| author |
Souriant, Shanti |
| author_facet |
Souriant, Shanti Balboa, Luciana Dupont, Maeva Pingris, Karine Kviatcovsky, Denise Cougoule, Céline Lastrucci, Claire Bah, Aicha Gasser, Romain Poincloux, Renaud Raynaud Messina, Brigitte Al Saati, Talal Inwentarz, Sandra Poggi, Susana Moraña, Eduardo Jose González Montaner, Pablo Corti, Marcelo Lagane, Bernard Vergne, Isabelle Allers, Carolina Kaushal, Deepak Kuroda, Marcelo J. Sasiain, Maria del Carmen Neyrolles, Olivier Maridonneau Parini, Isabelle Lugo Villarino, Geanncarlo Vérollet, Christel |
| author_role |
author |
| author2 |
Balboa, Luciana Dupont, Maeva Pingris, Karine Kviatcovsky, Denise Cougoule, Céline Lastrucci, Claire Bah, Aicha Gasser, Romain Poincloux, Renaud Raynaud Messina, Brigitte Al Saati, Talal Inwentarz, Sandra Poggi, Susana Moraña, Eduardo Jose González Montaner, Pablo Corti, Marcelo Lagane, Bernard Vergne, Isabelle Allers, Carolina Kaushal, Deepak Kuroda, Marcelo J. Sasiain, Maria del Carmen Neyrolles, Olivier Maridonneau Parini, Isabelle Lugo Villarino, Geanncarlo Vérollet, Christel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
AIDS BIOMARKER CO-INFECTION HIV-1 IL-10 MACROPHAGE MONOCYTE MYCOBACTERIUM TUBERCULOSIS STAT3 TUBERCULOSIS TUNNELING NANOTUBES VIRAL SPREAD |
| topic |
AIDS BIOMARKER CO-INFECTION HIV-1 IL-10 MACROPHAGE MONOCYTE MYCOBACTERIUM TUBERCULOSIS STAT3 TUBERCULOSIS TUNNELING NANOTUBES VIRAL SPREAD |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present in TB-associated microenvironment, produce high levels of HIV-1. In vivo, M(IL-10) macrophages are expanded in lungs of co-infected non-human primates, which correlates with disease severity. Furthermore, HIV-1/Mtb co-infected patients display an accumulation of M(IL-10) macrophage markers (soluble CD163 and MerTK). These M(IL-10) macrophages form direct cell-to-cell bridges, which we identified as tunneling nanotubes (TNTs) involved in viral transfer. TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages. Our study reveals that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics. Tuberculosis is a clear, yet confounding, risk factor for HIV-1-induced morbidity and mortality. In this issue, Souriant et al. reveal that a tuberculosis-associated microenvironment triggers IL-10/STAT3-dependent tunneling nanotube formation in M(IL-10) macrophages, which promotes HIV-1 exacerbation during co-infection. M(IL-10) macrophage accumulation is also observed in vivo in co-infected subjects. Fil: Souriant, Shanti. Université Paul Sabatier; Francia Fil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Dupont, Maeva. Centre National de la Recherche Scientifique; Francia Fil: Pingris, Karine. Centre National de la Recherche Scientifique; Francia Fil: Kviatcovsky, Denise. Centre National de la Recherche Scientifique; Francia Fil: Cougoule, Céline. Centre National de la Recherche Scientifique; Francia Fil: Lastrucci, Claire. Centro de Regulación Genómica; España Fil: Bah, Aicha. Université Paul Sabatier; Francia Fil: Gasser, Romain. Centre National de la Recherche Scientifique; Francia Fil: Poincloux, Renaud. Centre National de la Recherche Scientifique; Francia Fil: Raynaud Messina, Brigitte. Université de Toulouse; Francia Fil: Al Saati, Talal. Centro de Regulación Genómica; España Fil: Inwentarz, Sandra. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina Fil: Poggi, Susana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina Fil: Moraña, Eduardo Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina Fil: González Montaner, Pablo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina Fil: Corti, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina Fil: Lagane, Bernard. Université Paul Sabatier; Francia Fil: Vergne, Isabelle. Centre National de la Recherche Scientifique; Francia Fil: Allers, Carolina. University of Tulane; Estados Unidos Fil: Kaushal, Deepak. University of Tulane; Estados Unidos Fil: Kuroda, Marcelo J.. University of Tulane; Estados Unidos Fil: Sasiain, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Neyrolles, Olivier. Centre National de la Recherche Scientifique; Francia Fil: Maridonneau Parini, Isabelle. Université de Toulouse; ; Francia Fil: Lugo Villarino, Geanncarlo. No especifíca; Fil: Vérollet, Christel. Centre National de la Recherche Scientifique; Francia |
| description |
The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present in TB-associated microenvironment, produce high levels of HIV-1. In vivo, M(IL-10) macrophages are expanded in lungs of co-infected non-human primates, which correlates with disease severity. Furthermore, HIV-1/Mtb co-infected patients display an accumulation of M(IL-10) macrophage markers (soluble CD163 and MerTK). These M(IL-10) macrophages form direct cell-to-cell bridges, which we identified as tunneling nanotubes (TNTs) involved in viral transfer. TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages. Our study reveals that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics. Tuberculosis is a clear, yet confounding, risk factor for HIV-1-induced morbidity and mortality. In this issue, Souriant et al. reveal that a tuberculosis-associated microenvironment triggers IL-10/STAT3-dependent tunneling nanotube formation in M(IL-10) macrophages, which promotes HIV-1 exacerbation during co-infection. M(IL-10) macrophage accumulation is also observed in vivo in co-infected subjects. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-03 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/183500 Souriant, Shanti; Balboa, Luciana; Dupont, Maeva; Pingris, Karine; Kviatcovsky, Denise; et al.; Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages; Elsevier; Cell Reports; 26; 13; 3-2019; 3586-3599.e7 2211-1247 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/183500 |
| identifier_str_mv |
Souriant, Shanti; Balboa, Luciana; Dupont, Maeva; Pingris, Karine; Kviatcovsky, Denise; et al.; Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages; Elsevier; Cell Reports; 26; 13; 3-2019; 3586-3599.e7 2211-1247 CONICET Digital CONICET |
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eng |
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eng |
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