Drug repurposing strategy targeting serotonin-gated ion channels

Autores
Rodriguez Araujo, Noelia; Hernando, Guillermina Silvana; Bouzat, Cecilia Beatriz
Año de publicación
2022
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The need to achieve a greater understanding of the diverse array of medical problems imposes a kind of conducting force capable of pushing this continuously shifting exploration border towards areas of greater confidence. The science and the medical practice digging their backgrounds through hypotheses, experimental verifications, and subsequent interpretations are presently getting the input of Translational Medicine viewed as a goal of biomedical research aimed at offering better control tools. Something that is closely linked to the origins of the very medicine. The transition between basic and clinical research is complex requiring appropriate crosstalk helpful enough for the input/output relationship to become fruitful. Partly because the in vitro experiments and preclinical studies do not necessarily mirror the clinical situation to sensibly translate the “truth” emerging from laboratory data. This is particularly relevant when trying to develop new biomarkers, potentially predictive scoring systems, biostatistical procedures for combined endpoints, and mostly, the efforts towards the availability of novel therapeutic approaches. Regardless of the precise situation, intermingled communication between players from different fields is necessary, if we are about to establish new conceptual and methodological frameworks likely to facilitate a better theoretical/practical approach. To some extent, it constitutes a sort of burst of the biomedical sciences into the clinical scenario aimed at validating the knowledge arising in the laboratory to become part of some clinical practice or guidelines for health policies, with all the implications therein. Conversely, many clinical observations raise questions that can be elucidated from the experimental ground, as a valuable way of affording some feedback on this interactive process. The way ahead appears as long as challenging, given that the bulk of the investigative work carried out in our setting has been mostly performed in self-confined compartments (biomedical, clinical, and public health). Purportedly, we have lastly realized that field-specific speeches concentrated on themselves end up hindering the portrayal of problems in their different facets, as well as the way of formulating investigative designs addressed to provide improved alternatives
Fil: Rodriguez Araujo, Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Hernando, Guillermina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología y Reunión Anual 2022 de la Sociedad Argentina de Fisiología
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
Materia
FARMACOLOGÍA
SEROTONIN-GATED ION CHANNELS
DRUG REPURPOSING
Piperazine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226054
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Drug repurposing strategy targeting serotonin-gated ion channelsRodriguez Araujo, NoeliaHernando, Guillermina SilvanaBouzat, Cecilia BeatrizFARMACOLOGÍASEROTONIN-GATED ION CHANNELSDRUG REPURPOSINGPiperazinehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The need to achieve a greater understanding of the diverse array of medical problems imposes a kind of conducting force capable of pushing this continuously shifting exploration border towards areas of greater confidence. The science and the medical practice digging their backgrounds through hypotheses, experimental verifications, and subsequent interpretations are presently getting the input of Translational Medicine viewed as a goal of biomedical research aimed at offering better control tools. Something that is closely linked to the origins of the very medicine. The transition between basic and clinical research is complex requiring appropriate crosstalk helpful enough for the input/output relationship to become fruitful. Partly because the in vitro experiments and preclinical studies do not necessarily mirror the clinical situation to sensibly translate the “truth” emerging from laboratory data. This is particularly relevant when trying to develop new biomarkers, potentially predictive scoring systems, biostatistical procedures for combined endpoints, and mostly, the efforts towards the availability of novel therapeutic approaches. Regardless of the precise situation, intermingled communication between players from different fields is necessary, if we are about to establish new conceptual and methodological frameworks likely to facilitate a better theoretical/practical approach. To some extent, it constitutes a sort of burst of the biomedical sciences into the clinical scenario aimed at validating the knowledge arising in the laboratory to become part of some clinical practice or guidelines for health policies, with all the implications therein. Conversely, many clinical observations raise questions that can be elucidated from the experimental ground, as a valuable way of affording some feedback on this interactive process. The way ahead appears as long as challenging, given that the bulk of the investigative work carried out in our setting has been mostly performed in self-confined compartments (biomedical, clinical, and public health). Purportedly, we have lastly realized that field-specific speeches concentrated on themselves end up hindering the portrayal of problems in their different facets, as well as the way of formulating investigative designs addressed to provide improved alternativesFil: Rodriguez Araujo, Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Hernando, Guillermina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaLXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología y Reunión Anual 2022 de la Sociedad Argentina de FisiologíaMar del PlataArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226054Drug repurposing strategy targeting serotonin-gated ion channels; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología y Reunión Anual 2022 de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 94-940025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://medicinabuenosaires.com/revistas/vol82-22/s5/1s5.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:59Zoai:ri.conicet.gov.ar:11336/226054instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:00.265CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Drug repurposing strategy targeting serotonin-gated ion channels
title Drug repurposing strategy targeting serotonin-gated ion channels
spellingShingle Drug repurposing strategy targeting serotonin-gated ion channels
Rodriguez Araujo, Noelia
FARMACOLOGÍA
SEROTONIN-GATED ION CHANNELS
DRUG REPURPOSING
Piperazine
title_short Drug repurposing strategy targeting serotonin-gated ion channels
title_full Drug repurposing strategy targeting serotonin-gated ion channels
title_fullStr Drug repurposing strategy targeting serotonin-gated ion channels
title_full_unstemmed Drug repurposing strategy targeting serotonin-gated ion channels
title_sort Drug repurposing strategy targeting serotonin-gated ion channels
dc.creator.none.fl_str_mv Rodriguez Araujo, Noelia
Hernando, Guillermina Silvana
Bouzat, Cecilia Beatriz
author Rodriguez Araujo, Noelia
author_facet Rodriguez Araujo, Noelia
Hernando, Guillermina Silvana
Bouzat, Cecilia Beatriz
author_role author
author2 Hernando, Guillermina Silvana
Bouzat, Cecilia Beatriz
author2_role author
author
dc.subject.none.fl_str_mv FARMACOLOGÍA
SEROTONIN-GATED ION CHANNELS
DRUG REPURPOSING
Piperazine
topic FARMACOLOGÍA
SEROTONIN-GATED ION CHANNELS
DRUG REPURPOSING
Piperazine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The need to achieve a greater understanding of the diverse array of medical problems imposes a kind of conducting force capable of pushing this continuously shifting exploration border towards areas of greater confidence. The science and the medical practice digging their backgrounds through hypotheses, experimental verifications, and subsequent interpretations are presently getting the input of Translational Medicine viewed as a goal of biomedical research aimed at offering better control tools. Something that is closely linked to the origins of the very medicine. The transition between basic and clinical research is complex requiring appropriate crosstalk helpful enough for the input/output relationship to become fruitful. Partly because the in vitro experiments and preclinical studies do not necessarily mirror the clinical situation to sensibly translate the “truth” emerging from laboratory data. This is particularly relevant when trying to develop new biomarkers, potentially predictive scoring systems, biostatistical procedures for combined endpoints, and mostly, the efforts towards the availability of novel therapeutic approaches. Regardless of the precise situation, intermingled communication between players from different fields is necessary, if we are about to establish new conceptual and methodological frameworks likely to facilitate a better theoretical/practical approach. To some extent, it constitutes a sort of burst of the biomedical sciences into the clinical scenario aimed at validating the knowledge arising in the laboratory to become part of some clinical practice or guidelines for health policies, with all the implications therein. Conversely, many clinical observations raise questions that can be elucidated from the experimental ground, as a valuable way of affording some feedback on this interactive process. The way ahead appears as long as challenging, given that the bulk of the investigative work carried out in our setting has been mostly performed in self-confined compartments (biomedical, clinical, and public health). Purportedly, we have lastly realized that field-specific speeches concentrated on themselves end up hindering the portrayal of problems in their different facets, as well as the way of formulating investigative designs addressed to provide improved alternatives
Fil: Rodriguez Araujo, Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Hernando, Guillermina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología y Reunión Anual 2022 de la Sociedad Argentina de Fisiología
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
description The need to achieve a greater understanding of the diverse array of medical problems imposes a kind of conducting force capable of pushing this continuously shifting exploration border towards areas of greater confidence. The science and the medical practice digging their backgrounds through hypotheses, experimental verifications, and subsequent interpretations are presently getting the input of Translational Medicine viewed as a goal of biomedical research aimed at offering better control tools. Something that is closely linked to the origins of the very medicine. The transition between basic and clinical research is complex requiring appropriate crosstalk helpful enough for the input/output relationship to become fruitful. Partly because the in vitro experiments and preclinical studies do not necessarily mirror the clinical situation to sensibly translate the “truth” emerging from laboratory data. This is particularly relevant when trying to develop new biomarkers, potentially predictive scoring systems, biostatistical procedures for combined endpoints, and mostly, the efforts towards the availability of novel therapeutic approaches. Regardless of the precise situation, intermingled communication between players from different fields is necessary, if we are about to establish new conceptual and methodological frameworks likely to facilitate a better theoretical/practical approach. To some extent, it constitutes a sort of burst of the biomedical sciences into the clinical scenario aimed at validating the knowledge arising in the laboratory to become part of some clinical practice or guidelines for health policies, with all the implications therein. Conversely, many clinical observations raise questions that can be elucidated from the experimental ground, as a valuable way of affording some feedback on this interactive process. The way ahead appears as long as challenging, given that the bulk of the investigative work carried out in our setting has been mostly performed in self-confined compartments (biomedical, clinical, and public health). Purportedly, we have lastly realized that field-specific speeches concentrated on themselves end up hindering the portrayal of problems in their different facets, as well as the way of formulating investigative designs addressed to provide improved alternatives
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226054
Drug repurposing strategy targeting serotonin-gated ion channels; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología y Reunión Anual 2022 de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 94-94
0025-7680
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226054
identifier_str_mv Drug repurposing strategy targeting serotonin-gated ion channels; LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXX Reunión Anual de la Sociedad Argentina de Inmunología & 3er Congreso Franco Argentino de Inmunología y Reunión Anual 2022 de la Sociedad Argentina de Fisiología; Mar del Plata; Argentina; 2022; 94-94
0025-7680
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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publisher.none.fl_str_mv Fundación Revista Medicina
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