Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks

Autores
Caravajal, Pedro; Carlini, Valeria Paola; Schiöth, Helgi B.; Rubiales, Susana Elizabeth; Salvatierra, Nancy Alicia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly, on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect. Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr immediately after training showed an impairment of memory retention. However, there were no significant effects on the number of pecks during the pretraining, training, retention and discrimination. In addition, different doses of Ghr produced an inhibition in food intake at different times after injection. Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the first time that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an important role in the processes of memory retention in birds.
Fil: Caravajal, Pedro. Universidad Nacional de Córdoba; Argentina
Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Departamento de Farmacología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schiöth, Helgi B.. Uppsala University; Suecia
Fil: Rubiales, Susana Elizabeth. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Departamento de Farmacología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salvatierra, Nancy Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina
Materia
Anxiety
Food Intake
Gallus Gallus Domesticus
Memory Retention
One-Trial Passive Avoidance
Open Field Test
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57432
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/57432
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicksCaravajal, PedroCarlini, Valeria PaolaSchiöth, Helgi B.Rubiales, Susana ElizabethSalvatierra, Nancy AliciaAnxietyFood IntakeGallus Gallus DomesticusMemory RetentionOne-Trial Passive AvoidanceOpen Field Testhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly, on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect. Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr immediately after training showed an impairment of memory retention. However, there were no significant effects on the number of pecks during the pretraining, training, retention and discrimination. In addition, different doses of Ghr produced an inhibition in food intake at different times after injection. Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the first time that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an important role in the processes of memory retention in birds.Fil: Caravajal, Pedro. Universidad Nacional de Córdoba; ArgentinaFil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Departamento de Farmacología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schiöth, Helgi B.. Uppsala University; SueciaFil: Rubiales, Susana Elizabeth. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Departamento de Farmacología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salvatierra, Nancy Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; ArgentinaAcademic Press Inc Elsevier Science2009-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57432Caravajal, Pedro; Carlini, Valeria Paola; Schiöth, Helgi B.; Rubiales, Susana Elizabeth; Salvatierra, Nancy Alicia; Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 91; 4; 1-5-2009; 402-4071074-7427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2008.12.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:16Zoai:ri.conicet.gov.ar:11336/57432instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:16.31CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
title Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
spellingShingle Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
Caravajal, Pedro
Anxiety
Food Intake
Gallus Gallus Domesticus
Memory Retention
One-Trial Passive Avoidance
Open Field Test
title_short Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
title_full Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
title_fullStr Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
title_full_unstemmed Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
title_sort Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
dc.creator.none.fl_str_mv Caravajal, Pedro
Carlini, Valeria Paola
Schiöth, Helgi B.
Rubiales, Susana Elizabeth
Salvatierra, Nancy Alicia
author Caravajal, Pedro
author_facet Caravajal, Pedro
Carlini, Valeria Paola
Schiöth, Helgi B.
Rubiales, Susana Elizabeth
Salvatierra, Nancy Alicia
author_role author
author2 Carlini, Valeria Paola
Schiöth, Helgi B.
Rubiales, Susana Elizabeth
Salvatierra, Nancy Alicia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Anxiety
Food Intake
Gallus Gallus Domesticus
Memory Retention
One-Trial Passive Avoidance
Open Field Test
topic Anxiety
Food Intake
Gallus Gallus Domesticus
Memory Retention
One-Trial Passive Avoidance
Open Field Test
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly, on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect. Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr immediately after training showed an impairment of memory retention. However, there were no significant effects on the number of pecks during the pretraining, training, retention and discrimination. In addition, different doses of Ghr produced an inhibition in food intake at different times after injection. Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the first time that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an important role in the processes of memory retention in birds.
Fil: Caravajal, Pedro. Universidad Nacional de Córdoba; Argentina
Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Departamento de Farmacología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schiöth, Helgi B.. Uppsala University; Suecia
Fil: Rubiales, Susana Elizabeth. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Departamento de Farmacología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salvatierra, Nancy Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina
description Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly, on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect. Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr immediately after training showed an impairment of memory retention. However, there were no significant effects on the number of pecks during the pretraining, training, retention and discrimination. In addition, different doses of Ghr produced an inhibition in food intake at different times after injection. Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the first time that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an important role in the processes of memory retention in birds.
publishDate 2009
dc.date.none.fl_str_mv 2009-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57432
Caravajal, Pedro; Carlini, Valeria Paola; Schiöth, Helgi B.; Rubiales, Susana Elizabeth; Salvatierra, Nancy Alicia; Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 91; 4; 1-5-2009; 402-407
1074-7427
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57432
identifier_str_mv Caravajal, Pedro; Carlini, Valeria Paola; Schiöth, Helgi B.; Rubiales, Susana Elizabeth; Salvatierra, Nancy Alicia; Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 91; 4; 1-5-2009; 402-407
1074-7427
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2008.12.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.221938

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