Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues

Autores
Facciuto, Florencia Natalia; Cavatorta, Ana Laura; Bugnon Valdano, Marina Paula; Marziali, Federico Emanuel; Gardiol, Daniela Nora
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The general features of the PDZ domain structure and functions have beenextensively studied during the last decade. PDZ domains are generally pres-ent in proteins that are involved in multiple interactions to assemble func-tional protein complexes that control key cellular processes. One of thebest characterized functions of PDZ domain-containing proteins is controlof epithelial cell polarity and cell?cell contacts. In the present review, wesummarize the current knowledge on regulation of expression of certainPDZ polarity proteins localized at the intercellular junctions. In addition,we provide a critical overview of recent findings regarding the role of theseproteins during development of human diseases. Complete understandingof these issues is valuable for the design of novel therapeutic interventionfor common pathologies, such as cancer.
Fil: Facciuto, Florencia Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Cavatorta, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Bugnon Valdano, Marina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Marziali, Federico Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Gardiol, Daniela Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Materia
PDZ PROTEINS
REGULATION
EXPRESSION
CANCER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/270858
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/270858
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issuesFacciuto, Florencia NataliaCavatorta, Ana LauraBugnon Valdano, Marina PaulaMarziali, Federico EmanuelGardiol, Daniela NoraPDZ PROTEINSREGULATIONEXPRESSIONCANCERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The general features of the PDZ domain structure and functions have beenextensively studied during the last decade. PDZ domains are generally pres-ent in proteins that are involved in multiple interactions to assemble func-tional protein complexes that control key cellular processes. One of thebest characterized functions of PDZ domain-containing proteins is controlof epithelial cell polarity and cell?cell contacts. In the present review, wesummarize the current knowledge on regulation of expression of certainPDZ polarity proteins localized at the intercellular junctions. In addition,we provide a critical overview of recent findings regarding the role of theseproteins during development of human diseases. Complete understandingof these issues is valuable for the design of novel therapeutic interventionfor common pathologies, such as cancer.Fil: Facciuto, Florencia Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Cavatorta, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Bugnon Valdano, Marina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Marziali, Federico Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Gardiol, Daniela Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaWiley Blackwell Publishing, Inc2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270858Facciuto, Florencia Natalia; Cavatorta, Ana Laura; Bugnon Valdano, Marina Paula; Marziali, Federico Emanuel; Gardiol, Daniela Nora; Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues; Wiley Blackwell Publishing, Inc; Febs Journal; 279; 19; 8-2012; 3538-35481742-464XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2012.08699.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1742-4658.2012.08699.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:34Zoai:ri.conicet.gov.ar:11336/270858instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:35.204CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
title Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
spellingShingle Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
Facciuto, Florencia Natalia
PDZ PROTEINS
REGULATION
EXPRESSION
CANCER
title_short Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
title_full Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
title_fullStr Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
title_full_unstemmed Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
title_sort Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues
dc.creator.none.fl_str_mv Facciuto, Florencia Natalia
Cavatorta, Ana Laura
Bugnon Valdano, Marina Paula
Marziali, Federico Emanuel
Gardiol, Daniela Nora
author Facciuto, Florencia Natalia
author_facet Facciuto, Florencia Natalia
Cavatorta, Ana Laura
Bugnon Valdano, Marina Paula
Marziali, Federico Emanuel
Gardiol, Daniela Nora
author_role author
author2 Cavatorta, Ana Laura
Bugnon Valdano, Marina Paula
Marziali, Federico Emanuel
Gardiol, Daniela Nora
author2_role author
author
author
author
dc.subject.none.fl_str_mv PDZ PROTEINS
REGULATION
EXPRESSION
CANCER
topic PDZ PROTEINS
REGULATION
EXPRESSION
CANCER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The general features of the PDZ domain structure and functions have beenextensively studied during the last decade. PDZ domains are generally pres-ent in proteins that are involved in multiple interactions to assemble func-tional protein complexes that control key cellular processes. One of thebest characterized functions of PDZ domain-containing proteins is controlof epithelial cell polarity and cell?cell contacts. In the present review, wesummarize the current knowledge on regulation of expression of certainPDZ polarity proteins localized at the intercellular junctions. In addition,we provide a critical overview of recent findings regarding the role of theseproteins during development of human diseases. Complete understandingof these issues is valuable for the design of novel therapeutic interventionfor common pathologies, such as cancer.
Fil: Facciuto, Florencia Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Cavatorta, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Bugnon Valdano, Marina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Marziali, Federico Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Gardiol, Daniela Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
description The general features of the PDZ domain structure and functions have beenextensively studied during the last decade. PDZ domains are generally pres-ent in proteins that are involved in multiple interactions to assemble func-tional protein complexes that control key cellular processes. One of thebest characterized functions of PDZ domain-containing proteins is controlof epithelial cell polarity and cell?cell contacts. In the present review, wesummarize the current knowledge on regulation of expression of certainPDZ polarity proteins localized at the intercellular junctions. In addition,we provide a critical overview of recent findings regarding the role of theseproteins during development of human diseases. Complete understandingof these issues is valuable for the design of novel therapeutic interventionfor common pathologies, such as cancer.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/270858
Facciuto, Florencia Natalia; Cavatorta, Ana Laura; Bugnon Valdano, Marina Paula; Marziali, Federico Emanuel; Gardiol, Daniela Nora; Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues; Wiley Blackwell Publishing, Inc; Febs Journal; 279; 19; 8-2012; 3538-3548
1742-464X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/270858
identifier_str_mv Facciuto, Florencia Natalia; Cavatorta, Ana Laura; Bugnon Valdano, Marina Paula; Marziali, Federico Emanuel; Gardiol, Daniela Nora; Differential expression of PDZ domain‐containing proteins in human diseases – challenging topics and novel issues; Wiley Blackwell Publishing, Inc; Febs Journal; 279; 19; 8-2012; 3538-3548
1742-464X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2012.08699.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1742-4658.2012.08699.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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