Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses

Autores
Miño, Orlando Samuel; Barrandeguy, María; Parreño, Gladys Viviana; Parra, Gabriel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rotavirus virions are formed by three concentric protein layers that enclose the 11 dsRNA genome segments and the viral proteins VP1 and VP3. Interactions amongst the capsid proteins (VP2, VP6, VP7 and VP4) have been described to play a major role in viral fitness, whilst restricting the reassortment of the genomic segments during co-infection with different rotavirus strains. In this work we describe and characterize the linkage between VP6 and VP7 proteins based on structural and genomic analyses of group A rotavirus strains circulating in Argentinean horses. Strains with the VP7 genotype G3 showed a strong association with the VP6 genotype I6, whilst strains with G14 were associated with the I2 genotype. Most of the differences on the VP6 and VP7 proteins were observed in interactive regions between the two proteins, suggesting that VP6: VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments.
Fil: Miño, Orlando Samuel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Barrandeguy, María. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Universidad del Salvador. Escuela de Veterinaria; Argentina
Fil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Parra, Gabriel. Universidad Nacional de Asunción; Paraguay. National Institutes of Health; Estados Unidos
Materia
GENETIC LINKAGE
ROTAVIRUS
STRUCTURAL BIOLOGY
EQUINE DIARRHEA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89481
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetic linkage of capsid protein-encoding RNA segments in group A equine rotavirusesMiño, Orlando SamuelBarrandeguy, MaríaParreño, Gladys VivianaParra, GabrielGENETIC LINKAGEROTAVIRUSSTRUCTURAL BIOLOGYEQUINE DIARRHEAhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Rotavirus virions are formed by three concentric protein layers that enclose the 11 dsRNA genome segments and the viral proteins VP1 and VP3. Interactions amongst the capsid proteins (VP2, VP6, VP7 and VP4) have been described to play a major role in viral fitness, whilst restricting the reassortment of the genomic segments during co-infection with different rotavirus strains. In this work we describe and characterize the linkage between VP6 and VP7 proteins based on structural and genomic analyses of group A rotavirus strains circulating in Argentinean horses. Strains with the VP7 genotype G3 showed a strong association with the VP6 genotype I6, whilst strains with G14 were associated with the I2 genotype. Most of the differences on the VP6 and VP7 proteins were observed in interactive regions between the two proteins, suggesting that VP6: VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments.Fil: Miño, Orlando Samuel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; ArgentinaFil: Barrandeguy, María. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Universidad del Salvador. Escuela de Veterinaria; ArgentinaFil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; ArgentinaFil: Parra, Gabriel. Universidad Nacional de Asunción; Paraguay. National Institutes of Health; Estados UnidosSociety for General Microbiology2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89481Miño, Orlando Samuel; Barrandeguy, María; Parreño, Gladys Viviana; Parra, Gabriel; Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses; Society for General Microbiology; Journal of General Virology; 97; 4; 4-2016; 912-9210022-1317CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000397info:eu-repo/semantics/altIdentifier/doi/10.1099/jgv.0.000397info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:44:22Zoai:ri.conicet.gov.ar:11336/89481instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:44:22.37CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
title Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
spellingShingle Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
Miño, Orlando Samuel
GENETIC LINKAGE
ROTAVIRUS
STRUCTURAL BIOLOGY
EQUINE DIARRHEA
title_short Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
title_full Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
title_fullStr Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
title_full_unstemmed Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
title_sort Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses
dc.creator.none.fl_str_mv Miño, Orlando Samuel
Barrandeguy, María
Parreño, Gladys Viviana
Parra, Gabriel
author Miño, Orlando Samuel
author_facet Miño, Orlando Samuel
Barrandeguy, María
Parreño, Gladys Viviana
Parra, Gabriel
author_role author
author2 Barrandeguy, María
Parreño, Gladys Viviana
Parra, Gabriel
author2_role author
author
author
dc.subject.none.fl_str_mv GENETIC LINKAGE
ROTAVIRUS
STRUCTURAL BIOLOGY
EQUINE DIARRHEA
topic GENETIC LINKAGE
ROTAVIRUS
STRUCTURAL BIOLOGY
EQUINE DIARRHEA
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Rotavirus virions are formed by three concentric protein layers that enclose the 11 dsRNA genome segments and the viral proteins VP1 and VP3. Interactions amongst the capsid proteins (VP2, VP6, VP7 and VP4) have been described to play a major role in viral fitness, whilst restricting the reassortment of the genomic segments during co-infection with different rotavirus strains. In this work we describe and characterize the linkage between VP6 and VP7 proteins based on structural and genomic analyses of group A rotavirus strains circulating in Argentinean horses. Strains with the VP7 genotype G3 showed a strong association with the VP6 genotype I6, whilst strains with G14 were associated with the I2 genotype. Most of the differences on the VP6 and VP7 proteins were observed in interactive regions between the two proteins, suggesting that VP6: VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments.
Fil: Miño, Orlando Samuel. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Barrandeguy, María. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Universidad del Salvador. Escuela de Veterinaria; Argentina
Fil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Parra, Gabriel. Universidad Nacional de Asunción; Paraguay. National Institutes of Health; Estados Unidos
description Rotavirus virions are formed by three concentric protein layers that enclose the 11 dsRNA genome segments and the viral proteins VP1 and VP3. Interactions amongst the capsid proteins (VP2, VP6, VP7 and VP4) have been described to play a major role in viral fitness, whilst restricting the reassortment of the genomic segments during co-infection with different rotavirus strains. In this work we describe and characterize the linkage between VP6 and VP7 proteins based on structural and genomic analyses of group A rotavirus strains circulating in Argentinean horses. Strains with the VP7 genotype G3 showed a strong association with the VP6 genotype I6, whilst strains with G14 were associated with the I2 genotype. Most of the differences on the VP6 and VP7 proteins were observed in interactive regions between the two proteins, suggesting that VP6: VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89481
Miño, Orlando Samuel; Barrandeguy, María; Parreño, Gladys Viviana; Parra, Gabriel; Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses; Society for General Microbiology; Journal of General Virology; 97; 4; 4-2016; 912-921
0022-1317
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89481
identifier_str_mv Miño, Orlando Samuel; Barrandeguy, María; Parreño, Gladys Viviana; Parra, Gabriel; Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses; Society for General Microbiology; Journal of General Virology; 97; 4; 4-2016; 912-921
0022-1317
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000397
info:eu-repo/semantics/altIdentifier/doi/10.1099/jgv.0.000397
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for General Microbiology
publisher.none.fl_str_mv Society for General Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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