Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons

Autores
González Domínguez, José Miguel; Gutierrez, Fabiana Andrea; Hernández Ferrer, Javier; Anson Casaos, Alejandro; Rubianes, María Dolores; Rivas, Gustavo Adolfo; Martinez, Maria Teresa
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Peptide-based biomaterials are being studied actively in a variety of applications in materials science and biointerface engineering. Likewise, there has been ongoing exploration over the last few decades into the potential biological applications of carbon nanomaterials, motivated by their size, shape, structure and their unique physical and chemical properties. In recent years, the functionalization of carbon nanotubes and graphene has led to the preparation of bioactive carbon nanomaterials that are being used in biomedicine as structural elements and in gene therapy and biosensing. The present study proposes different strategies for the bonding of L-tyrosine and the homopolypeptide poly-L-tyrosine to graphene oxide nanoribbons (GONRs). The covalent attachment of L-tyrosine was undertaken by amidation of the α-amine group of tyrosine with the existing carboxylic groups in GONR and by means of esterification through phenol nucleophiles contained in their side chains. In both cases use was made of protective groups to address the functionalization with the desired reactive groups. The linking of GONRs to the PTyr was attempted according to two different strategies: either by ester bonding of commercial PTyr through its phenol side groups or by in situ ring-opening polymerization of an N-carboxyanhydride tyrosine derivative (NCA-Tyr) with Tyr-functionalized GONRs. These biofunctionalized nanomaterials were characterized by Raman and infrared spectroscopies, X-ray photoelectron spectroscopy, thermogravimetric analysis, transmission electron microscopy, fluorescence and electrochemical techniques. On the basis of their properties, prospects for the potential utilization of the prepared hybrid nanomaterials in different applications are also given.
Fil: González Domínguez, José Miguel. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Gutierrez, Fabiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Hernández Ferrer, Javier. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Anson Casaos, Alejandro. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Martinez, Maria Teresa. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Materia
Graphene Nanoribbons
L-Tyrosine
Poly-L-Tyrosine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47132
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47132
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbonsGonzález Domínguez, José MiguelGutierrez, Fabiana AndreaHernández Ferrer, JavierAnson Casaos, AlejandroRubianes, María DoloresRivas, Gustavo AdolfoMartinez, Maria TeresaGraphene NanoribbonsL-TyrosinePoly-L-Tyrosinehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Peptide-based biomaterials are being studied actively in a variety of applications in materials science and biointerface engineering. Likewise, there has been ongoing exploration over the last few decades into the potential biological applications of carbon nanomaterials, motivated by their size, shape, structure and their unique physical and chemical properties. In recent years, the functionalization of carbon nanotubes and graphene has led to the preparation of bioactive carbon nanomaterials that are being used in biomedicine as structural elements and in gene therapy and biosensing. The present study proposes different strategies for the bonding of L-tyrosine and the homopolypeptide poly-L-tyrosine to graphene oxide nanoribbons (GONRs). The covalent attachment of L-tyrosine was undertaken by amidation of the α-amine group of tyrosine with the existing carboxylic groups in GONR and by means of esterification through phenol nucleophiles contained in their side chains. In both cases use was made of protective groups to address the functionalization with the desired reactive groups. The linking of GONRs to the PTyr was attempted according to two different strategies: either by ester bonding of commercial PTyr through its phenol side groups or by in situ ring-opening polymerization of an N-carboxyanhydride tyrosine derivative (NCA-Tyr) with Tyr-functionalized GONRs. These biofunctionalized nanomaterials were characterized by Raman and infrared spectroscopies, X-ray photoelectron spectroscopy, thermogravimetric analysis, transmission electron microscopy, fluorescence and electrochemical techniques. On the basis of their properties, prospects for the potential utilization of the prepared hybrid nanomaterials in different applications are also given.Fil: González Domínguez, José Miguel. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Gutierrez, Fabiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Hernández Ferrer, Javier. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Anson Casaos, Alejandro. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Martinez, Maria Teresa. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaRoyal Society of Chemistry2015-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47132González Domínguez, José Miguel; Gutierrez, Fabiana Andrea; Hernández Ferrer, Javier; Anson Casaos, Alejandro; Rubianes, María Dolores; et al.; Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons; Royal Society of Chemistry; Journal Of Materials Chemistry; 3; 18; 31-3-2015; 3870-38842050-750X2050-7518CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://rsc.li/2LYwd8jinfo:eu-repo/semantics/altIdentifier/doi/10.1039/c4tb02122cinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:41:01Zoai:ri.conicet.gov.ar:11336/47132instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:41:01.815CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
title Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
spellingShingle Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
González Domínguez, José Miguel
Graphene Nanoribbons
L-Tyrosine
Poly-L-Tyrosine
title_short Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
title_full Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
title_fullStr Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
title_full_unstemmed Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
title_sort Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons
dc.creator.none.fl_str_mv González Domínguez, José Miguel
Gutierrez, Fabiana Andrea
Hernández Ferrer, Javier
Anson Casaos, Alejandro
Rubianes, María Dolores
Rivas, Gustavo Adolfo
Martinez, Maria Teresa
author González Domínguez, José Miguel
author_facet González Domínguez, José Miguel
Gutierrez, Fabiana Andrea
Hernández Ferrer, Javier
Anson Casaos, Alejandro
Rubianes, María Dolores
Rivas, Gustavo Adolfo
Martinez, Maria Teresa
author_role author
author2 Gutierrez, Fabiana Andrea
Hernández Ferrer, Javier
Anson Casaos, Alejandro
Rubianes, María Dolores
Rivas, Gustavo Adolfo
Martinez, Maria Teresa
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Graphene Nanoribbons
L-Tyrosine
Poly-L-Tyrosine
topic Graphene Nanoribbons
L-Tyrosine
Poly-L-Tyrosine
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Peptide-based biomaterials are being studied actively in a variety of applications in materials science and biointerface engineering. Likewise, there has been ongoing exploration over the last few decades into the potential biological applications of carbon nanomaterials, motivated by their size, shape, structure and their unique physical and chemical properties. In recent years, the functionalization of carbon nanotubes and graphene has led to the preparation of bioactive carbon nanomaterials that are being used in biomedicine as structural elements and in gene therapy and biosensing. The present study proposes different strategies for the bonding of L-tyrosine and the homopolypeptide poly-L-tyrosine to graphene oxide nanoribbons (GONRs). The covalent attachment of L-tyrosine was undertaken by amidation of the α-amine group of tyrosine with the existing carboxylic groups in GONR and by means of esterification through phenol nucleophiles contained in their side chains. In both cases use was made of protective groups to address the functionalization with the desired reactive groups. The linking of GONRs to the PTyr was attempted according to two different strategies: either by ester bonding of commercial PTyr through its phenol side groups or by in situ ring-opening polymerization of an N-carboxyanhydride tyrosine derivative (NCA-Tyr) with Tyr-functionalized GONRs. These biofunctionalized nanomaterials were characterized by Raman and infrared spectroscopies, X-ray photoelectron spectroscopy, thermogravimetric analysis, transmission electron microscopy, fluorescence and electrochemical techniques. On the basis of their properties, prospects for the potential utilization of the prepared hybrid nanomaterials in different applications are also given.
Fil: González Domínguez, José Miguel. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Gutierrez, Fabiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Hernández Ferrer, Javier. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Anson Casaos, Alejandro. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Martinez, Maria Teresa. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
description Peptide-based biomaterials are being studied actively in a variety of applications in materials science and biointerface engineering. Likewise, there has been ongoing exploration over the last few decades into the potential biological applications of carbon nanomaterials, motivated by their size, shape, structure and their unique physical and chemical properties. In recent years, the functionalization of carbon nanotubes and graphene has led to the preparation of bioactive carbon nanomaterials that are being used in biomedicine as structural elements and in gene therapy and biosensing. The present study proposes different strategies for the bonding of L-tyrosine and the homopolypeptide poly-L-tyrosine to graphene oxide nanoribbons (GONRs). The covalent attachment of L-tyrosine was undertaken by amidation of the α-amine group of tyrosine with the existing carboxylic groups in GONR and by means of esterification through phenol nucleophiles contained in their side chains. In both cases use was made of protective groups to address the functionalization with the desired reactive groups. The linking of GONRs to the PTyr was attempted according to two different strategies: either by ester bonding of commercial PTyr through its phenol side groups or by in situ ring-opening polymerization of an N-carboxyanhydride tyrosine derivative (NCA-Tyr) with Tyr-functionalized GONRs. These biofunctionalized nanomaterials were characterized by Raman and infrared spectroscopies, X-ray photoelectron spectroscopy, thermogravimetric analysis, transmission electron microscopy, fluorescence and electrochemical techniques. On the basis of their properties, prospects for the potential utilization of the prepared hybrid nanomaterials in different applications are also given.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-31
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47132
González Domínguez, José Miguel; Gutierrez, Fabiana Andrea; Hernández Ferrer, Javier; Anson Casaos, Alejandro; Rubianes, María Dolores; et al.; Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons; Royal Society of Chemistry; Journal Of Materials Chemistry; 3; 18; 31-3-2015; 3870-3884
2050-750X
2050-7518
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47132
identifier_str_mv González Domínguez, José Miguel; Gutierrez, Fabiana Andrea; Hernández Ferrer, Javier; Anson Casaos, Alejandro; Rubianes, María Dolores; et al.; Peptide-based biomaterials. Linking l -tyrosine and poly l -tyrosine to graphene oxide nanoribbons; Royal Society of Chemistry; Journal Of Materials Chemistry; 3; 18; 31-3-2015; 3870-3884
2050-750X
2050-7518
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://rsc.li/2LYwd8j
info:eu-repo/semantics/altIdentifier/doi/10.1039/c4tb02122c
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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