The stressed life of a lipid in the Zika virus membrane
- Autores
- Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.
Fil: Soñora, Martín. Instituto Pasteur de Montevideo; Uruguay
Fil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay - Materia
-
COARSE-GRAIN
FLAVIVIRUS
MOLECULAR DYNAMICS
SIMULATION
SIRAH
VLP
ZIKA VIRUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/205669
Ver los metadatos del registro completo
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The stressed life of a lipid in the Zika virus membraneSoñora, MartínBarrera Guisasola, Exequiel ErnestoPantano, SergioCOARSE-GRAINFLAVIVIRUSMOLECULAR DYNAMICSSIMULATIONSIRAHVLPZIKA VIRUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.Fil: Soñora, Martín. Instituto Pasteur de Montevideo; UruguayFil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Pantano, Sergio. Instituto Pasteur de Montevideo; UruguayElsevier Science2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/205669Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-110005-2736CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0005273621002522info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbamem.2021.183804info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:07:47Zoai:ri.conicet.gov.ar:11336/205669instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:07:47.606CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The stressed life of a lipid in the Zika virus membrane |
title |
The stressed life of a lipid in the Zika virus membrane |
spellingShingle |
The stressed life of a lipid in the Zika virus membrane Soñora, Martín COARSE-GRAIN FLAVIVIRUS MOLECULAR DYNAMICS SIMULATION SIRAH VLP ZIKA VIRUS |
title_short |
The stressed life of a lipid in the Zika virus membrane |
title_full |
The stressed life of a lipid in the Zika virus membrane |
title_fullStr |
The stressed life of a lipid in the Zika virus membrane |
title_full_unstemmed |
The stressed life of a lipid in the Zika virus membrane |
title_sort |
The stressed life of a lipid in the Zika virus membrane |
dc.creator.none.fl_str_mv |
Soñora, Martín Barrera Guisasola, Exequiel Ernesto Pantano, Sergio |
author |
Soñora, Martín |
author_facet |
Soñora, Martín Barrera Guisasola, Exequiel Ernesto Pantano, Sergio |
author_role |
author |
author2 |
Barrera Guisasola, Exequiel Ernesto Pantano, Sergio |
author2_role |
author author |
dc.subject.none.fl_str_mv |
COARSE-GRAIN FLAVIVIRUS MOLECULAR DYNAMICS SIMULATION SIRAH VLP ZIKA VIRUS |
topic |
COARSE-GRAIN FLAVIVIRUS MOLECULAR DYNAMICS SIMULATION SIRAH VLP ZIKA VIRUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process. Fil: Soñora, Martín. Instituto Pasteur de Montevideo; Uruguay Fil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay |
description |
Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/205669 Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-11 0005-2736 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/205669 |
identifier_str_mv |
Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-11 0005-2736 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0005273621002522 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbamem.2021.183804 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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12.928904 |