The stressed life of a lipid in the Zika virus membrane

Autores
Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.
Fil: Soñora, Martín. Instituto Pasteur de Montevideo; Uruguay
Fil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay
Materia
COARSE-GRAIN
FLAVIVIRUS
MOLECULAR DYNAMICS
SIMULATION
SIRAH
VLP
ZIKA VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/205669
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/205669
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The stressed life of a lipid in the Zika virus membraneSoñora, MartínBarrera Guisasola, Exequiel ErnestoPantano, SergioCOARSE-GRAINFLAVIVIRUSMOLECULAR DYNAMICSSIMULATIONSIRAHVLPZIKA VIRUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.Fil: Soñora, Martín. Instituto Pasteur de Montevideo; UruguayFil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Pantano, Sergio. Instituto Pasteur de Montevideo; UruguayElsevier Science2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/205669Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-110005-2736CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0005273621002522info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbamem.2021.183804info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:07:47Zoai:ri.conicet.gov.ar:11336/205669instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:07:47.606CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The stressed life of a lipid in the Zika virus membrane
title The stressed life of a lipid in the Zika virus membrane
spellingShingle The stressed life of a lipid in the Zika virus membrane
Soñora, Martín
COARSE-GRAIN
FLAVIVIRUS
MOLECULAR DYNAMICS
SIMULATION
SIRAH
VLP
ZIKA VIRUS
title_short The stressed life of a lipid in the Zika virus membrane
title_full The stressed life of a lipid in the Zika virus membrane
title_fullStr The stressed life of a lipid in the Zika virus membrane
title_full_unstemmed The stressed life of a lipid in the Zika virus membrane
title_sort The stressed life of a lipid in the Zika virus membrane
dc.creator.none.fl_str_mv Soñora, Martín
Barrera Guisasola, Exequiel Ernesto
Pantano, Sergio
author Soñora, Martín
author_facet Soñora, Martín
Barrera Guisasola, Exequiel Ernesto
Pantano, Sergio
author_role author
author2 Barrera Guisasola, Exequiel Ernesto
Pantano, Sergio
author2_role author
author
dc.subject.none.fl_str_mv COARSE-GRAIN
FLAVIVIRUS
MOLECULAR DYNAMICS
SIMULATION
SIRAH
VLP
ZIKA VIRUS
topic COARSE-GRAIN
FLAVIVIRUS
MOLECULAR DYNAMICS
SIMULATION
SIRAH
VLP
ZIKA VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.
Fil: Soñora, Martín. Instituto Pasteur de Montevideo; Uruguay
Fil: Barrera Guisasola, Exequiel Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay
description Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because the intrinsically small dimensions of the molecular systems escape to the current resolution of experimental techniques. However, coarse-grained and multiscale simulations may fill that niche, providing nearly atomistic resolution at an affordable computational price. Here we use multiscale simulations to characterize the lipid-protein interactions in the envelope of the Zika Virus, a prominent member of the Flavivirus genus. Comparisons between the viral envelope and simpler molecular systems indicate that the viral membrane is under extreme pressures and asymmetric forces. Furthermore, the dense net of protein-protein contacts established by the envelope proteins creates poorly solvated regions that destabilize the external leaflet leading to a decoupled dynamics between both membrane layers. These findings lead to the idea that the Flaviviral membrane may store a significant amount of elastic energy, playing an active role in the membrane fusion process.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/205669
Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-11
0005-2736
CONICET Digital
CONICET
url http://hdl.handle.net/11336/205669
identifier_str_mv Soñora, Martín; Barrera Guisasola, Exequiel Ernesto; Pantano, Sergio; The stressed life of a lipid in the Zika virus membrane; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 1; 2-2022; 1-11
0005-2736
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0005273621002522
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbamem.2021.183804
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.928904

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