Exercise heart rates in patients with hypertrophic cardiomyopathy

Autores
Luo, Hong-Chang; Dimaano, Veronica L.; Kembro, Jackelyn Melissa; Hilser, Alex; Hurtado-De-Mendoza, David; Pozios, Iraklis; Tomas, Miguel S.; Yalcin, Hulya; Dolores-Cerna, Ketty; Mormontoy, Wilfredo; Aon, Miguel A.; Cameron, Duke; Bluemke, David A.; Stewart, Kerry J.; Russell, Stuart D.; Cordova, Jorge G.; Abraham, Theodore P.; Abraham, M. Roselle
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.
Fil: Luo, Hong-Chang. Tongji Hospital; China. University Johns Hopkins; Estados Unidos
Fil: Dimaano, Veronica L.. University Johns Hopkins; Estados Unidos
Fil: Kembro, Jackelyn Melissa. University Johns Hopkins; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Hilser, Alex. University Johns Hopkins; Estados Unidos
Fil: Hurtado-De-Mendoza, David. University Johns Hopkins; Estados Unidos
Fil: Pozios, Iraklis. University Johns Hopkins; Estados Unidos
Fil: Tomas, Miguel S.. University Johns Hopkins; Estados Unidos
Fil: Yalcin, Hulya. University Johns Hopkins; Estados Unidos
Fil: Dolores-Cerna, Ketty. University Johns Hopkins; Estados Unidos
Fil: Mormontoy, Wilfredo. University Johns Hopkins; Estados Unidos
Fil: Aon, Miguel A.. University Johns Hopkins; Estados Unidos
Fil: Cameron, Duke. Universidad Peruana Cayetano Heredia; Perú
Fil: Bluemke, David A.. National Institute Of Biomedical Imaging And Bioengineering;
Fil: Stewart, Kerry J.. University Johns Hopkins; Estados Unidos
Fil: Russell, Stuart D.. University Johns Hopkins; Estados Unidos
Fil: Cordova, Jorge G.. University Johns Hopkins; Estados Unidos
Fil: Abraham, Theodore P.. University Johns Hopkins; Estados Unidos
Fil: Abraham, M. Roselle. University Johns Hopkins; Estados Unidos
Materia
Heart Rate Recovery
Chronotropic Response
Hypertrophic Cardiomyopathy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40341
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/40341
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exercise heart rates in patients with hypertrophic cardiomyopathyLuo, Hong-ChangDimaano, Veronica L.Kembro, Jackelyn MelissaHilser, AlexHurtado-De-Mendoza, DavidPozios, IraklisTomas, Miguel S.Yalcin, HulyaDolores-Cerna, KettyMormontoy, WilfredoAon, Miguel A.Cameron, DukeBluemke, David A.Stewart, Kerry J.Russell, Stuart D.Cordova, Jorge G.Abraham, Theodore P.Abraham, M. RoselleHeart Rate RecoveryChronotropic ResponseHypertrophic Cardiomyopathyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.Fil: Luo, Hong-Chang. Tongji Hospital; China. University Johns Hopkins; Estados UnidosFil: Dimaano, Veronica L.. University Johns Hopkins; Estados UnidosFil: Kembro, Jackelyn Melissa. University Johns Hopkins; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Hilser, Alex. University Johns Hopkins; Estados UnidosFil: Hurtado-De-Mendoza, David. University Johns Hopkins; Estados UnidosFil: Pozios, Iraklis. University Johns Hopkins; Estados UnidosFil: Tomas, Miguel S.. University Johns Hopkins; Estados UnidosFil: Yalcin, Hulya. University Johns Hopkins; Estados UnidosFil: Dolores-Cerna, Ketty. University Johns Hopkins; Estados UnidosFil: Mormontoy, Wilfredo. University Johns Hopkins; Estados UnidosFil: Aon, Miguel A.. University Johns Hopkins; Estados UnidosFil: Cameron, Duke. Universidad Peruana Cayetano Heredia; PerúFil: Bluemke, David A.. National Institute Of Biomedical Imaging And Bioengineering;Fil: Stewart, Kerry J.. University Johns Hopkins; Estados UnidosFil: Russell, Stuart D.. University Johns Hopkins; Estados UnidosFil: Cordova, Jorge G.. University Johns Hopkins; Estados UnidosFil: Abraham, Theodore P.. University Johns Hopkins; Estados UnidosFil: Abraham, M. Roselle. University Johns Hopkins; Estados UnidosExcerpta Medica Inc-elsevier Science Inc2015-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40341Luo, Hong-Chang; Dimaano, Veronica L.; Kembro, Jackelyn Melissa; Hilser, Alex; Hurtado-De-Mendoza, David; et al.; Exercise heart rates in patients with hypertrophic cardiomyopathy; Excerpta Medica Inc-elsevier Science Inc; American Journal Of Cardiology; 115; 8; 15-4-2015; 1144-11500002-9149CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.amjcard.2015.01.548info:eu-repo/semantics/altIdentifier/url/http://www.ajconline.org/article/S0002-9149(15)00643-8/fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:52Zoai:ri.conicet.gov.ar:11336/40341instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:52.502CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exercise heart rates in patients with hypertrophic cardiomyopathy
title Exercise heart rates in patients with hypertrophic cardiomyopathy
spellingShingle Exercise heart rates in patients with hypertrophic cardiomyopathy
Luo, Hong-Chang
Heart Rate Recovery
Chronotropic Response
Hypertrophic Cardiomyopathy
title_short Exercise heart rates in patients with hypertrophic cardiomyopathy
title_full Exercise heart rates in patients with hypertrophic cardiomyopathy
title_fullStr Exercise heart rates in patients with hypertrophic cardiomyopathy
title_full_unstemmed Exercise heart rates in patients with hypertrophic cardiomyopathy
title_sort Exercise heart rates in patients with hypertrophic cardiomyopathy
dc.creator.none.fl_str_mv Luo, Hong-Chang
Dimaano, Veronica L.
Kembro, Jackelyn Melissa
Hilser, Alex
Hurtado-De-Mendoza, David
Pozios, Iraklis
Tomas, Miguel S.
Yalcin, Hulya
Dolores-Cerna, Ketty
Mormontoy, Wilfredo
Aon, Miguel A.
Cameron, Duke
Bluemke, David A.
Stewart, Kerry J.
Russell, Stuart D.
Cordova, Jorge G.
Abraham, Theodore P.
Abraham, M. Roselle
author Luo, Hong-Chang
author_facet Luo, Hong-Chang
Dimaano, Veronica L.
Kembro, Jackelyn Melissa
Hilser, Alex
Hurtado-De-Mendoza, David
Pozios, Iraklis
Tomas, Miguel S.
Yalcin, Hulya
Dolores-Cerna, Ketty
Mormontoy, Wilfredo
Aon, Miguel A.
Cameron, Duke
Bluemke, David A.
Stewart, Kerry J.
Russell, Stuart D.
Cordova, Jorge G.
Abraham, Theodore P.
Abraham, M. Roselle
author_role author
author2 Dimaano, Veronica L.
Kembro, Jackelyn Melissa
Hilser, Alex
Hurtado-De-Mendoza, David
Pozios, Iraklis
Tomas, Miguel S.
Yalcin, Hulya
Dolores-Cerna, Ketty
Mormontoy, Wilfredo
Aon, Miguel A.
Cameron, Duke
Bluemke, David A.
Stewart, Kerry J.
Russell, Stuart D.
Cordova, Jorge G.
Abraham, Theodore P.
Abraham, M. Roselle
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Heart Rate Recovery
Chronotropic Response
Hypertrophic Cardiomyopathy
topic Heart Rate Recovery
Chronotropic Response
Hypertrophic Cardiomyopathy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.
Fil: Luo, Hong-Chang. Tongji Hospital; China. University Johns Hopkins; Estados Unidos
Fil: Dimaano, Veronica L.. University Johns Hopkins; Estados Unidos
Fil: Kembro, Jackelyn Melissa. University Johns Hopkins; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Hilser, Alex. University Johns Hopkins; Estados Unidos
Fil: Hurtado-De-Mendoza, David. University Johns Hopkins; Estados Unidos
Fil: Pozios, Iraklis. University Johns Hopkins; Estados Unidos
Fil: Tomas, Miguel S.. University Johns Hopkins; Estados Unidos
Fil: Yalcin, Hulya. University Johns Hopkins; Estados Unidos
Fil: Dolores-Cerna, Ketty. University Johns Hopkins; Estados Unidos
Fil: Mormontoy, Wilfredo. University Johns Hopkins; Estados Unidos
Fil: Aon, Miguel A.. University Johns Hopkins; Estados Unidos
Fil: Cameron, Duke. Universidad Peruana Cayetano Heredia; Perú
Fil: Bluemke, David A.. National Institute Of Biomedical Imaging And Bioengineering;
Fil: Stewart, Kerry J.. University Johns Hopkins; Estados Unidos
Fil: Russell, Stuart D.. University Johns Hopkins; Estados Unidos
Fil: Cordova, Jorge G.. University Johns Hopkins; Estados Unidos
Fil: Abraham, Theodore P.. University Johns Hopkins; Estados Unidos
Fil: Abraham, M. Roselle. University Johns Hopkins; Estados Unidos
description The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40341
Luo, Hong-Chang; Dimaano, Veronica L.; Kembro, Jackelyn Melissa; Hilser, Alex; Hurtado-De-Mendoza, David; et al.; Exercise heart rates in patients with hypertrophic cardiomyopathy; Excerpta Medica Inc-elsevier Science Inc; American Journal Of Cardiology; 115; 8; 15-4-2015; 1144-1150
0002-9149
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40341
identifier_str_mv Luo, Hong-Chang; Dimaano, Veronica L.; Kembro, Jackelyn Melissa; Hilser, Alex; Hurtado-De-Mendoza, David; et al.; Exercise heart rates in patients with hypertrophic cardiomyopathy; Excerpta Medica Inc-elsevier Science Inc; American Journal Of Cardiology; 115; 8; 15-4-2015; 1144-1150
0002-9149
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.amjcard.2015.01.548
info:eu-repo/semantics/altIdentifier/url/http://www.ajconline.org/article/S0002-9149(15)00643-8/fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Excerpta Medica Inc-elsevier Science Inc
publisher.none.fl_str_mv Excerpta Medica Inc-elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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