Establishment and development of intestinal microbiota in preterm neonates

Autores
Arboleya, Silvia; Binetti, Ana Griselda; Salazar, Nuria; Fernández, Nuria; Solís, Gonzalo; Hernández Barranco, Ana; Margolles, Abelardo; de los Reyes Gavilán, Clara G.; Gueimonde, Miguel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Microbial colonization of the infant gut is essential for the development of the intestine and the immune system. The profile of intestinal microbiota in the full-term, vaginally delivered, breast-fed infant is considered as ideally healthy. However, in preterm infants this process is challenging, mainly because of organ immaturity, antibiotics use, and hospital stay. To assist in a proper microbiota development in these infants, a detailed knowledge of the colonization process, and the differences from that of full-term breast-fed infants, is needed. We assessed the establishment of the gut microbiota and its metabolic activity in preterm neonates (n = 21) during the first 3 months of life and compared it with that of vaginally delivered, exclusively breast-fed full-term infants (n = 20) using qualitative and quantitative culture-independent methods. Differences in the gut microbiota composition between both groups were observed. Preterm infants showed higher levels of facultative anaerobic microorganisms and reduced levels of strict anaerobes such as Bifidobacterium, Bacteroides, and Atopobium. Short-chain fatty acids concentrations were lower in preterm infants during the first days of life. Alterations occur in the process of microbiota establishment in preterm infants, indicating the need for intervention strategies to counteract them.
Fil: Arboleya, Silvia. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Binetti, Ana Griselda. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Salazar, Nuria. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Fernández, Nuria. Hospital de Cabueñes; Estados Unidos
Fil: Solís, Gonzalo. Hospital Universitario Central de Asturias; España
Fil: Hernández Barranco, Ana. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Margolles, Abelardo. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: de los Reyes Gavilán, Clara G.. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Gueimonde, Miguel. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Materia
Infants
Intestinal Microbiota
Preterm Neonates
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/70886
Acceder
id CONICETDig_62cf4cecfce4bae9970609b6d58386ae
oai_identifier_str oai:ri.conicet.gov.ar:11336/70886
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Establishment and development of intestinal microbiota in preterm neonatesArboleya, SilviaBinetti, Ana GriseldaSalazar, NuriaFernández, NuriaSolís, GonzaloHernández Barranco, AnaMargolles, Abelardode los Reyes Gavilán, Clara G.Gueimonde, MiguelInfantsIntestinal MicrobiotaPreterm Neonateshttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Microbial colonization of the infant gut is essential for the development of the intestine and the immune system. The profile of intestinal microbiota in the full-term, vaginally delivered, breast-fed infant is considered as ideally healthy. However, in preterm infants this process is challenging, mainly because of organ immaturity, antibiotics use, and hospital stay. To assist in a proper microbiota development in these infants, a detailed knowledge of the colonization process, and the differences from that of full-term breast-fed infants, is needed. We assessed the establishment of the gut microbiota and its metabolic activity in preterm neonates (n = 21) during the first 3 months of life and compared it with that of vaginally delivered, exclusively breast-fed full-term infants (n = 20) using qualitative and quantitative culture-independent methods. Differences in the gut microbiota composition between both groups were observed. Preterm infants showed higher levels of facultative anaerobic microorganisms and reduced levels of strict anaerobes such as Bifidobacterium, Bacteroides, and Atopobium. Short-chain fatty acids concentrations were lower in preterm infants during the first days of life. Alterations occur in the process of microbiota establishment in preterm infants, indicating the need for intervention strategies to counteract them.Fil: Arboleya, Silvia. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; EspañaFil: Binetti, Ana Griselda. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Salazar, Nuria. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; EspañaFil: Fernández, Nuria. Hospital de Cabueñes; Estados UnidosFil: Solís, Gonzalo. Hospital Universitario Central de Asturias; EspañaFil: Hernández Barranco, Ana. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; EspañaFil: Margolles, Abelardo. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; EspañaFil: de los Reyes Gavilán, Clara G.. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; EspañaFil: Gueimonde, Miguel. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; EspañaOxford University Press2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70886Arboleya, Silvia; Binetti, Ana Griselda; Salazar, Nuria; Fernández, Nuria; Solís, Gonzalo; et al.; Establishment and development of intestinal microbiota in preterm neonates; Oxford University Press; Fems Microbiology Ecology; 79; 3; 3-2012; 763-7720168-6496CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-6941.2011.01261.xinfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsec/article/79/3/763/492968info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:55Zoai:ri.conicet.gov.ar:11336/70886instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:56.143CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Establishment and development of intestinal microbiota in preterm neonates
title Establishment and development of intestinal microbiota in preterm neonates
spellingShingle Establishment and development of intestinal microbiota in preterm neonates
Arboleya, Silvia
Infants
Intestinal Microbiota
Preterm Neonates
title_short Establishment and development of intestinal microbiota in preterm neonates
title_full Establishment and development of intestinal microbiota in preterm neonates
title_fullStr Establishment and development of intestinal microbiota in preterm neonates
title_full_unstemmed Establishment and development of intestinal microbiota in preterm neonates
title_sort Establishment and development of intestinal microbiota in preterm neonates
dc.creator.none.fl_str_mv Arboleya, Silvia
Binetti, Ana Griselda
Salazar, Nuria
Fernández, Nuria
Solís, Gonzalo
Hernández Barranco, Ana
Margolles, Abelardo
de los Reyes Gavilán, Clara G.
Gueimonde, Miguel
author Arboleya, Silvia
author_facet Arboleya, Silvia
Binetti, Ana Griselda
Salazar, Nuria
Fernández, Nuria
Solís, Gonzalo
Hernández Barranco, Ana
Margolles, Abelardo
de los Reyes Gavilán, Clara G.
Gueimonde, Miguel
author_role author
author2 Binetti, Ana Griselda
Salazar, Nuria
Fernández, Nuria
Solís, Gonzalo
Hernández Barranco, Ana
Margolles, Abelardo
de los Reyes Gavilán, Clara G.
Gueimonde, Miguel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infants
Intestinal Microbiota
Preterm Neonates
topic Infants
Intestinal Microbiota
Preterm Neonates
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Microbial colonization of the infant gut is essential for the development of the intestine and the immune system. The profile of intestinal microbiota in the full-term, vaginally delivered, breast-fed infant is considered as ideally healthy. However, in preterm infants this process is challenging, mainly because of organ immaturity, antibiotics use, and hospital stay. To assist in a proper microbiota development in these infants, a detailed knowledge of the colonization process, and the differences from that of full-term breast-fed infants, is needed. We assessed the establishment of the gut microbiota and its metabolic activity in preterm neonates (n = 21) during the first 3 months of life and compared it with that of vaginally delivered, exclusively breast-fed full-term infants (n = 20) using qualitative and quantitative culture-independent methods. Differences in the gut microbiota composition between both groups were observed. Preterm infants showed higher levels of facultative anaerobic microorganisms and reduced levels of strict anaerobes such as Bifidobacterium, Bacteroides, and Atopobium. Short-chain fatty acids concentrations were lower in preterm infants during the first days of life. Alterations occur in the process of microbiota establishment in preterm infants, indicating the need for intervention strategies to counteract them.
Fil: Arboleya, Silvia. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Binetti, Ana Griselda. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Salazar, Nuria. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Fernández, Nuria. Hospital de Cabueñes; Estados Unidos
Fil: Solís, Gonzalo. Hospital Universitario Central de Asturias; España
Fil: Hernández Barranco, Ana. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Margolles, Abelardo. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: de los Reyes Gavilán, Clara G.. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
Fil: Gueimonde, Miguel. Consejo Superior de Investigaciones Científicas. Instituto Superior de Productos Lacteos de Asturias; España
description Microbial colonization of the infant gut is essential for the development of the intestine and the immune system. The profile of intestinal microbiota in the full-term, vaginally delivered, breast-fed infant is considered as ideally healthy. However, in preterm infants this process is challenging, mainly because of organ immaturity, antibiotics use, and hospital stay. To assist in a proper microbiota development in these infants, a detailed knowledge of the colonization process, and the differences from that of full-term breast-fed infants, is needed. We assessed the establishment of the gut microbiota and its metabolic activity in preterm neonates (n = 21) during the first 3 months of life and compared it with that of vaginally delivered, exclusively breast-fed full-term infants (n = 20) using qualitative and quantitative culture-independent methods. Differences in the gut microbiota composition between both groups were observed. Preterm infants showed higher levels of facultative anaerobic microorganisms and reduced levels of strict anaerobes such as Bifidobacterium, Bacteroides, and Atopobium. Short-chain fatty acids concentrations were lower in preterm infants during the first days of life. Alterations occur in the process of microbiota establishment in preterm infants, indicating the need for intervention strategies to counteract them.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/70886
Arboleya, Silvia; Binetti, Ana Griselda; Salazar, Nuria; Fernández, Nuria; Solís, Gonzalo; et al.; Establishment and development of intestinal microbiota in preterm neonates; Oxford University Press; Fems Microbiology Ecology; 79; 3; 3-2012; 763-772
0168-6496
CONICET Digital
CONICET
url http://hdl.handle.net/11336/70886
identifier_str_mv Arboleya, Silvia; Binetti, Ana Griselda; Salazar, Nuria; Fernández, Nuria; Solís, Gonzalo; et al.; Establishment and development of intestinal microbiota in preterm neonates; Oxford University Press; Fems Microbiology Ecology; 79; 3; 3-2012; 763-772
0168-6496
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-6941.2011.01261.x
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsec/article/79/3/763/492968
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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