Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success

Autores
Jaworski, Juan Pablo; Vendrell, Alejandrina; Chiavenna, Sebastián Matias
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.
Fil: Jaworski, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires; Argentina
Fil: Vendrell, Alejandrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Chiavenna, Sebastián Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ferrer Advanced Biotherapeutics; España
Materia
Human Immunodeficiency Virus
Neutralizing Antibodies
Prophylaxis
Reservoir
Treatment
Vaccine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78376
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of successJaworski, Juan PabloVendrell, AlejandrinaChiavenna, Sebastián MatiasHuman Immunodeficiency VirusNeutralizing AntibodiesProphylaxisReservoirTreatmentVaccinehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.Fil: Jaworski, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires; ArgentinaFil: Vendrell, Alejandrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Chiavenna, Sebastián Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ferrer Advanced Biotherapeutics; EspañaFrontiers Media S.A.2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78376Jaworski, Juan Pablo; Vendrell, Alejandrina; Chiavenna, Sebastián Matias; Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success; Frontiers Media S.A.; Frontiers in Immunology; 7; JAN; 1-20171664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225137/info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2016.00661info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2016.00661info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:49Zoai:ri.conicet.gov.ar:11336/78376instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:49.606CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
title Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
spellingShingle Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
Jaworski, Juan Pablo
Human Immunodeficiency Virus
Neutralizing Antibodies
Prophylaxis
Reservoir
Treatment
Vaccine
title_short Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
title_full Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
title_fullStr Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
title_full_unstemmed Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
title_sort Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success
dc.creator.none.fl_str_mv Jaworski, Juan Pablo
Vendrell, Alejandrina
Chiavenna, Sebastián Matias
author Jaworski, Juan Pablo
author_facet Jaworski, Juan Pablo
Vendrell, Alejandrina
Chiavenna, Sebastián Matias
author_role author
author2 Vendrell, Alejandrina
Chiavenna, Sebastián Matias
author2_role author
author
dc.subject.none.fl_str_mv Human Immunodeficiency Virus
Neutralizing Antibodies
Prophylaxis
Reservoir
Treatment
Vaccine
topic Human Immunodeficiency Virus
Neutralizing Antibodies
Prophylaxis
Reservoir
Treatment
Vaccine
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.
Fil: Jaworski, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires; Argentina
Fil: Vendrell, Alejandrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Chiavenna, Sebastián Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ferrer Advanced Biotherapeutics; España
description Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78376
Jaworski, Juan Pablo; Vendrell, Alejandrina; Chiavenna, Sebastián Matias; Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success; Frontiers Media S.A.; Frontiers in Immunology; 7; JAN; 1-2017
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78376
identifier_str_mv Jaworski, Juan Pablo; Vendrell, Alejandrina; Chiavenna, Sebastián Matias; Neutralizing monoclonal antibodies to fight HIV-1: On the threshold of success; Frontiers Media S.A.; Frontiers in Immunology; 7; JAN; 1-2017
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225137/
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2016.00661
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2016.00661
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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