Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism

Autores
Ash, Ryan T.; Palagina, Ganna; Fernandez Leon, Jose Alberto; Park, Jiyoung; Seilheimer, Rob; Lee, Sangkyun; Sabharwal, Jasdeep; Reyes, Fredy; Wang, Jing; Lu, Dylan; Sarfraz, Muhammad; Froudarakis, Emmanouil; Tolias, Andreas S.; Wu, Samuel M.; Smirnakis, Stelios M.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Atypical sensory processing is now thought to be a core feature of the autism spectrum. Influential theories have proposed that both increased and decreased neural response reliability within sensory systems could underlie altered sensory processing in autism. Here, we report evidence for abnormally increased reliability of visual-evoked responses in layer 2/3 neurons of adult male and female primary visual cortex in the MECP2-duplication syndrome animal model of autism. Increased response reliability was due in part to decreased response amplitude, decreased fluctuations in endogenous activity, and an abnormal decoupling of visual-evoked activity from endogenous activity. Similar to what was observed neuronally, the optokinetic reflex occurred more reliably at low contrasts in mutant mice compared with controls. Retinal responses did not explain our observations. These data suggest that the circuit mechanisms for combining sensory-evoked and endogenous signal and noise processes may be altered in this form of syndromic autism.
Fil: Ash, Ryan T.. Baylor College of Medicine; Estados Unidos. Harvard Medical School; Estados Unidos. University of Stanford; Estados Unidos
Fil: Palagina, Ganna. Harvard Medical School; Estados Unidos
Fil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Park, Jiyoung. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos
Fil: Seilheimer, Rob. University of Pennsylvania; Estados Unidos. Baylor College of Medicine; Estados Unidos
Fil: Lee, Sangkyun. Harvard Medical School; Estados Unidos
Fil: Sabharwal, Jasdeep. Baylor College of Medicine; Estados Unidos. University Johns Hopkins; Estados Unidos
Fil: Reyes, Fredy. Baylor College of Medicine; Estados Unidos
Fil: Wang, Jing. Baylor College of Medicine; Estados Unidos
Fil: Lu, Dylan. Harvard Medical School; Estados Unidos
Fil: Sarfraz, Muhammad. Harvard Medical School; Estados Unidos
Fil: Froudarakis, Emmanouil. Baylor College of Medicine; Estados Unidos. Foundation For Research And Technology; Grecia
Fil: Tolias, Andreas S.. Baylor College of Medicine; Estados Unidos
Fil: Wu, Samuel M.. Baylor College of Medicine; Estados Unidos
Fil: Smirnakis, Stelios M.. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos
Materia
ASD
AUTISM
CALCIUM IMAGING
MECP2
MOUSE
VISUAL CORTEX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/215639
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of AutismAsh, Ryan T.Palagina, GannaFernandez Leon, Jose AlbertoPark, JiyoungSeilheimer, RobLee, SangkyunSabharwal, JasdeepReyes, FredyWang, JingLu, DylanSarfraz, MuhammadFroudarakis, EmmanouilTolias, Andreas S.Wu, Samuel M.Smirnakis, Stelios M.ASDAUTISMCALCIUM IMAGINGMECP2MOUSEVISUAL CORTEXhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Atypical sensory processing is now thought to be a core feature of the autism spectrum. Influential theories have proposed that both increased and decreased neural response reliability within sensory systems could underlie altered sensory processing in autism. Here, we report evidence for abnormally increased reliability of visual-evoked responses in layer 2/3 neurons of adult male and female primary visual cortex in the MECP2-duplication syndrome animal model of autism. Increased response reliability was due in part to decreased response amplitude, decreased fluctuations in endogenous activity, and an abnormal decoupling of visual-evoked activity from endogenous activity. Similar to what was observed neuronally, the optokinetic reflex occurred more reliably at low contrasts in mutant mice compared with controls. Retinal responses did not explain our observations. These data suggest that the circuit mechanisms for combining sensory-evoked and endogenous signal and noise processes may be altered in this form of syndromic autism.Fil: Ash, Ryan T.. Baylor College of Medicine; Estados Unidos. Harvard Medical School; Estados Unidos. University of Stanford; Estados UnidosFil: Palagina, Ganna. Harvard Medical School; Estados UnidosFil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Park, Jiyoung. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados UnidosFil: Seilheimer, Rob. University of Pennsylvania; Estados Unidos. Baylor College of Medicine; Estados UnidosFil: Lee, Sangkyun. Harvard Medical School; Estados UnidosFil: Sabharwal, Jasdeep. Baylor College of Medicine; Estados Unidos. University Johns Hopkins; Estados UnidosFil: Reyes, Fredy. Baylor College of Medicine; Estados UnidosFil: Wang, Jing. Baylor College of Medicine; Estados UnidosFil: Lu, Dylan. Harvard Medical School; Estados UnidosFil: Sarfraz, Muhammad. Harvard Medical School; Estados UnidosFil: Froudarakis, Emmanouil. Baylor College of Medicine; Estados Unidos. Foundation For Research And Technology; GreciaFil: Tolias, Andreas S.. Baylor College of Medicine; Estados UnidosFil: Wu, Samuel M.. Baylor College of Medicine; Estados UnidosFil: Smirnakis, Stelios M.. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados UnidosSociety for Neuroscience2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/215639Ash, Ryan T.; Palagina, Ganna; Fernandez Leon, Jose Alberto; Park, Jiyoung; Seilheimer, Rob; et al.; Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism; Society for Neuroscience; Journal of Neuroscience; 42; 33; 8-2022; 6469-64820270-6474CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.0654-22.2022info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/42/33/6469info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:24:21Zoai:ri.conicet.gov.ar:11336/215639instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:24:21.975CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
title Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
spellingShingle Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
Ash, Ryan T.
ASD
AUTISM
CALCIUM IMAGING
MECP2
MOUSE
VISUAL CORTEX
title_short Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
title_full Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
title_fullStr Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
title_full_unstemmed Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
title_sort Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism
dc.creator.none.fl_str_mv Ash, Ryan T.
Palagina, Ganna
Fernandez Leon, Jose Alberto
Park, Jiyoung
Seilheimer, Rob
Lee, Sangkyun
Sabharwal, Jasdeep
Reyes, Fredy
Wang, Jing
Lu, Dylan
Sarfraz, Muhammad
Froudarakis, Emmanouil
Tolias, Andreas S.
Wu, Samuel M.
Smirnakis, Stelios M.
author Ash, Ryan T.
author_facet Ash, Ryan T.
Palagina, Ganna
Fernandez Leon, Jose Alberto
Park, Jiyoung
Seilheimer, Rob
Lee, Sangkyun
Sabharwal, Jasdeep
Reyes, Fredy
Wang, Jing
Lu, Dylan
Sarfraz, Muhammad
Froudarakis, Emmanouil
Tolias, Andreas S.
Wu, Samuel M.
Smirnakis, Stelios M.
author_role author
author2 Palagina, Ganna
Fernandez Leon, Jose Alberto
Park, Jiyoung
Seilheimer, Rob
Lee, Sangkyun
Sabharwal, Jasdeep
Reyes, Fredy
Wang, Jing
Lu, Dylan
Sarfraz, Muhammad
Froudarakis, Emmanouil
Tolias, Andreas S.
Wu, Samuel M.
Smirnakis, Stelios M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ASD
AUTISM
CALCIUM IMAGING
MECP2
MOUSE
VISUAL CORTEX
topic ASD
AUTISM
CALCIUM IMAGING
MECP2
MOUSE
VISUAL CORTEX
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Atypical sensory processing is now thought to be a core feature of the autism spectrum. Influential theories have proposed that both increased and decreased neural response reliability within sensory systems could underlie altered sensory processing in autism. Here, we report evidence for abnormally increased reliability of visual-evoked responses in layer 2/3 neurons of adult male and female primary visual cortex in the MECP2-duplication syndrome animal model of autism. Increased response reliability was due in part to decreased response amplitude, decreased fluctuations in endogenous activity, and an abnormal decoupling of visual-evoked activity from endogenous activity. Similar to what was observed neuronally, the optokinetic reflex occurred more reliably at low contrasts in mutant mice compared with controls. Retinal responses did not explain our observations. These data suggest that the circuit mechanisms for combining sensory-evoked and endogenous signal and noise processes may be altered in this form of syndromic autism.
Fil: Ash, Ryan T.. Baylor College of Medicine; Estados Unidos. Harvard Medical School; Estados Unidos. University of Stanford; Estados Unidos
Fil: Palagina, Ganna. Harvard Medical School; Estados Unidos
Fil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Park, Jiyoung. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos
Fil: Seilheimer, Rob. University of Pennsylvania; Estados Unidos. Baylor College of Medicine; Estados Unidos
Fil: Lee, Sangkyun. Harvard Medical School; Estados Unidos
Fil: Sabharwal, Jasdeep. Baylor College of Medicine; Estados Unidos. University Johns Hopkins; Estados Unidos
Fil: Reyes, Fredy. Baylor College of Medicine; Estados Unidos
Fil: Wang, Jing. Baylor College of Medicine; Estados Unidos
Fil: Lu, Dylan. Harvard Medical School; Estados Unidos
Fil: Sarfraz, Muhammad. Harvard Medical School; Estados Unidos
Fil: Froudarakis, Emmanouil. Baylor College of Medicine; Estados Unidos. Foundation For Research And Technology; Grecia
Fil: Tolias, Andreas S.. Baylor College of Medicine; Estados Unidos
Fil: Wu, Samuel M.. Baylor College of Medicine; Estados Unidos
Fil: Smirnakis, Stelios M.. Harvard Medical School; Estados Unidos. Baylor College of Medicine; Estados Unidos
description Atypical sensory processing is now thought to be a core feature of the autism spectrum. Influential theories have proposed that both increased and decreased neural response reliability within sensory systems could underlie altered sensory processing in autism. Here, we report evidence for abnormally increased reliability of visual-evoked responses in layer 2/3 neurons of adult male and female primary visual cortex in the MECP2-duplication syndrome animal model of autism. Increased response reliability was due in part to decreased response amplitude, decreased fluctuations in endogenous activity, and an abnormal decoupling of visual-evoked activity from endogenous activity. Similar to what was observed neuronally, the optokinetic reflex occurred more reliably at low contrasts in mutant mice compared with controls. Retinal responses did not explain our observations. These data suggest that the circuit mechanisms for combining sensory-evoked and endogenous signal and noise processes may be altered in this form of syndromic autism.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/215639
Ash, Ryan T.; Palagina, Ganna; Fernandez Leon, Jose Alberto; Park, Jiyoung; Seilheimer, Rob; et al.; Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism; Society for Neuroscience; Journal of Neuroscience; 42; 33; 8-2022; 6469-6482
0270-6474
CONICET Digital
CONICET
url http://hdl.handle.net/11336/215639
identifier_str_mv Ash, Ryan T.; Palagina, Ganna; Fernandez Leon, Jose Alberto; Park, Jiyoung; Seilheimer, Rob; et al.; Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism; Society for Neuroscience; Journal of Neuroscience; 42; 33; 8-2022; 6469-6482
0270-6474
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.0654-22.2022
info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/42/33/6469
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781781467987968
score 12.982451

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