Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children

Autores
Gaddi, E.; Laucella, Susana Adriana; Balbaryski, J.; Cantisano, C.; Barboni, G.; Candi, M.; Giraudi, V.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Central events in the host defence system and immune-mediated damage are tightly regulated by celladhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided intogroups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied todetect the presence of soluble intercellular adhesion molecu le-1 (s-ICAM-1). Soluble ICAM-1 levels werefound to be significantly increased in HIV-infected children in comparison with SR children or healthycontrols. Levels of soluble ICAM-1 were higher in patients with severe forms of HIV-infection than in thosewith a milder form of the disease. Significant differences in titers of s-ICAM-1 were recorded between SRchildren and HIV-infected children with mild disease or healthy controls. There was a significant correlationbetween s-ICAM-1 levels and the concentrations of beta 2 microglobulin (b2m) and, to a lesser extend,immunoglobulin A levels (IgA). Soluble ICAM-1 levels didn't change considerably in HIV-infected childrenin stable clini cal conditions, independently of their clinical stage of the disease, during a follow-up period of9±12 months. Conversely, s-ICAM-1 levels increased simultaneously with the appearance of new well-defined clini cal disorders or decreased during the improvement of clinical conditions. A significant negativecorrelation was recorded between the titers of the s-ICAM-1 and the CD41T-cell levels. These resultssuggest that the s-ICAM-1 might be another useful tool to evaluate disease progression.
Fil: Gaddi, E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Laucella, Susana Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Balbaryski, J.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Cantisano, C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Barboni, G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Candi, M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Giraudi, V.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Materia
HIV
CHILDREN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71655
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/71655
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected ChildrenGaddi, E.Laucella, Susana AdrianaBalbaryski, J.Cantisano, C.Barboni, G.Candi, M.Giraudi, V.HIVCHILDRENhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Central events in the host defence system and immune-mediated damage are tightly regulated by celladhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided intogroups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied todetect the presence of soluble intercellular adhesion molecu le-1 (s-ICAM-1). Soluble ICAM-1 levels werefound to be significantly increased in HIV-infected children in comparison with SR children or healthycontrols. Levels of soluble ICAM-1 were higher in patients with severe forms of HIV-infection than in thosewith a milder form of the disease. Significant differences in titers of s-ICAM-1 were recorded between SRchildren and HIV-infected children with mild disease or healthy controls. There was a significant correlationbetween s-ICAM-1 levels and the concentrations of beta 2 microglobulin (b2m) and, to a lesser extend,immunoglobulin A levels (IgA). Soluble ICAM-1 levels didn't change considerably in HIV-infected childrenin stable clini cal conditions, independently of their clinical stage of the disease, during a follow-up period of9±12 months. Conversely, s-ICAM-1 levels increased simultaneously with the appearance of new well-defined clini cal disorders or decreased during the improvement of clinical conditions. A significant negativecorrelation was recorded between the titers of the s-ICAM-1 and the CD41T-cell levels. These resultssuggest that the s-ICAM-1 might be another useful tool to evaluate disease progression.Fil: Gaddi, E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Laucella, Susana Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Balbaryski, J.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Cantisano, C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Barboni, G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Candi, M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Giraudi, V.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaWiley Blackwell Publishing, Inc2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71655Gaddi, E.; Laucella, Susana Adriana; Balbaryski, J.; Cantisano, C.; Barboni, G.; et al.; Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children; Wiley Blackwell Publishing, Inc; Scandinavian Journal Of Immunology; 52; 6; 7-2008; 628-6330300-9475CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-3083.2000.00820.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2000.00820.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:18Zoai:ri.conicet.gov.ar:11336/71655instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:19.044CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
title Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
spellingShingle Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
Gaddi, E.
HIV
CHILDREN
title_short Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
title_full Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
title_fullStr Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
title_full_unstemmed Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
title_sort Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children
dc.creator.none.fl_str_mv Gaddi, E.
Laucella, Susana Adriana
Balbaryski, J.
Cantisano, C.
Barboni, G.
Candi, M.
Giraudi, V.
author Gaddi, E.
author_facet Gaddi, E.
Laucella, Susana Adriana
Balbaryski, J.
Cantisano, C.
Barboni, G.
Candi, M.
Giraudi, V.
author_role author
author2 Laucella, Susana Adriana
Balbaryski, J.
Cantisano, C.
Barboni, G.
Candi, M.
Giraudi, V.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv HIV
CHILDREN
topic HIV
CHILDREN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Central events in the host defence system and immune-mediated damage are tightly regulated by celladhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided intogroups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied todetect the presence of soluble intercellular adhesion molecu le-1 (s-ICAM-1). Soluble ICAM-1 levels werefound to be significantly increased in HIV-infected children in comparison with SR children or healthycontrols. Levels of soluble ICAM-1 were higher in patients with severe forms of HIV-infection than in thosewith a milder form of the disease. Significant differences in titers of s-ICAM-1 were recorded between SRchildren and HIV-infected children with mild disease or healthy controls. There was a significant correlationbetween s-ICAM-1 levels and the concentrations of beta 2 microglobulin (b2m) and, to a lesser extend,immunoglobulin A levels (IgA). Soluble ICAM-1 levels didn't change considerably in HIV-infected childrenin stable clini cal conditions, independently of their clinical stage of the disease, during a follow-up period of9±12 months. Conversely, s-ICAM-1 levels increased simultaneously with the appearance of new well-defined clini cal disorders or decreased during the improvement of clinical conditions. A significant negativecorrelation was recorded between the titers of the s-ICAM-1 and the CD41T-cell levels. These resultssuggest that the s-ICAM-1 might be another useful tool to evaluate disease progression.
Fil: Gaddi, E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Laucella, Susana Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Balbaryski, J.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Cantisano, C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Barboni, G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Candi, M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Giraudi, V.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
description Central events in the host defence system and immune-mediated damage are tightly regulated by celladhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided intogroups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied todetect the presence of soluble intercellular adhesion molecu le-1 (s-ICAM-1). Soluble ICAM-1 levels werefound to be significantly increased in HIV-infected children in comparison with SR children or healthycontrols. Levels of soluble ICAM-1 were higher in patients with severe forms of HIV-infection than in thosewith a milder form of the disease. Significant differences in titers of s-ICAM-1 were recorded between SRchildren and HIV-infected children with mild disease or healthy controls. There was a significant correlationbetween s-ICAM-1 levels and the concentrations of beta 2 microglobulin (b2m) and, to a lesser extend,immunoglobulin A levels (IgA). Soluble ICAM-1 levels didn't change considerably in HIV-infected childrenin stable clini cal conditions, independently of their clinical stage of the disease, during a follow-up period of9±12 months. Conversely, s-ICAM-1 levels increased simultaneously with the appearance of new well-defined clini cal disorders or decreased during the improvement of clinical conditions. A significant negativecorrelation was recorded between the titers of the s-ICAM-1 and the CD41T-cell levels. These resultssuggest that the s-ICAM-1 might be another useful tool to evaluate disease progression.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71655
Gaddi, E.; Laucella, Susana Adriana; Balbaryski, J.; Cantisano, C.; Barboni, G.; et al.; Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children; Wiley Blackwell Publishing, Inc; Scandinavian Journal Of Immunology; 52; 6; 7-2008; 628-633
0300-9475
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71655
identifier_str_mv Gaddi, E.; Laucella, Susana Adriana; Balbaryski, J.; Cantisano, C.; Barboni, G.; et al.; Prognostic Value of Soluble Intercellular Adhesion Molecule-1 (s-ICAM-1) in HIV-Infected Children; Wiley Blackwell Publishing, Inc; Scandinavian Journal Of Immunology; 52; 6; 7-2008; 628-633
0300-9475
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-3083.2000.00820.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2000.00820.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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