SIRT6 is required for normal retinal function

Autores
Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; Apte, Rajendra S.; Mostoslavsky, Raul
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.
Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados Unidos
Fil: Ross, Kenneth. Harvard Medical School; Estados Unidos
Fil: Sande, Pablo H.. Harvard Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Kubota, Shunsuke. Washington University in St. Louis; Estados Unidos
Fil: Ramaswamy, Sridhar. Harvard Medical School; Estados Unidos
Fil: Apte, Rajendra S.. Washington University in St. Louis; Estados Unidos
Fil: Mostoslavsky, Raul. Harvard University; Estados Unidos
Materia
retina
SIRT6
epigenetic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13660
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling SIRT6 is required for normal retinal functionSilberman, Dafne MagaliRoss, KennethSande, Pablo H.Kubota, ShunsukeRamaswamy, SridharApte, Rajendra S.Mostoslavsky, RaulretinaSIRT6epigenetichttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados UnidosFil: Ross, Kenneth. Harvard Medical School; Estados UnidosFil: Sande, Pablo H.. Harvard Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Kubota, Shunsuke. Washington University in St. Louis; Estados UnidosFil: Ramaswamy, Sridhar. Harvard Medical School; Estados UnidosFil: Apte, Rajendra S.. Washington University in St. Louis; Estados UnidosFil: Mostoslavsky, Raul. Harvard University; Estados UnidosPublic Library Of Science2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13660Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; et al.; SIRT6 is required for normal retinal function; Public Library Of Science; Plos One; 9; 6; 6-2014; 6-111932-6203enginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098831info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0098831info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24896097info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:57:30Zoai:ri.conicet.gov.ar:11336/13660instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:57:31.195CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv SIRT6 is required for normal retinal function
title SIRT6 is required for normal retinal function
spellingShingle SIRT6 is required for normal retinal function
Silberman, Dafne Magali
retina
SIRT6
epigenetic
title_short SIRT6 is required for normal retinal function
title_full SIRT6 is required for normal retinal function
title_fullStr SIRT6 is required for normal retinal function
title_full_unstemmed SIRT6 is required for normal retinal function
title_sort SIRT6 is required for normal retinal function
dc.creator.none.fl_str_mv Silberman, Dafne Magali
Ross, Kenneth
Sande, Pablo H.
Kubota, Shunsuke
Ramaswamy, Sridhar
Apte, Rajendra S.
Mostoslavsky, Raul
author Silberman, Dafne Magali
author_facet Silberman, Dafne Magali
Ross, Kenneth
Sande, Pablo H.
Kubota, Shunsuke
Ramaswamy, Sridhar
Apte, Rajendra S.
Mostoslavsky, Raul
author_role author
author2 Ross, Kenneth
Sande, Pablo H.
Kubota, Shunsuke
Ramaswamy, Sridhar
Apte, Rajendra S.
Mostoslavsky, Raul
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv retina
SIRT6
epigenetic
topic retina
SIRT6
epigenetic
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.
Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados Unidos
Fil: Ross, Kenneth. Harvard Medical School; Estados Unidos
Fil: Sande, Pablo H.. Harvard Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Kubota, Shunsuke. Washington University in St. Louis; Estados Unidos
Fil: Ramaswamy, Sridhar. Harvard Medical School; Estados Unidos
Fil: Apte, Rajendra S.. Washington University in St. Louis; Estados Unidos
Fil: Mostoslavsky, Raul. Harvard University; Estados Unidos
description The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13660
Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; et al.; SIRT6 is required for normal retinal function; Public Library Of Science; Plos One; 9; 6; 6-2014; 6-11
1932-6203
url http://hdl.handle.net/11336/13660
identifier_str_mv Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; et al.; SIRT6 is required for normal retinal function; Public Library Of Science; Plos One; 9; 6; 6-2014; 6-11
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098831
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0098831
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24896097
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Of Science
publisher.none.fl_str_mv Public Library Of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782285823606784
score 12.982451

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