SIRT6 is required for normal retinal function
- Autores
- Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; Apte, Rajendra S.; Mostoslavsky, Raul
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.
Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados Unidos
Fil: Ross, Kenneth. Harvard Medical School; Estados Unidos
Fil: Sande, Pablo H.. Harvard Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Kubota, Shunsuke. Washington University in St. Louis; Estados Unidos
Fil: Ramaswamy, Sridhar. Harvard Medical School; Estados Unidos
Fil: Apte, Rajendra S.. Washington University in St. Louis; Estados Unidos
Fil: Mostoslavsky, Raul. Harvard University; Estados Unidos - Materia
-
retina
SIRT6
epigenetic - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/13660
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SIRT6 is required for normal retinal functionSilberman, Dafne MagaliRoss, KennethSande, Pablo H.Kubota, ShunsukeRamaswamy, SridharApte, Rajendra S.Mostoslavsky, RaulretinaSIRT6epigenetichttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados UnidosFil: Ross, Kenneth. Harvard Medical School; Estados UnidosFil: Sande, Pablo H.. Harvard Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Kubota, Shunsuke. Washington University in St. Louis; Estados UnidosFil: Ramaswamy, Sridhar. Harvard Medical School; Estados UnidosFil: Apte, Rajendra S.. Washington University in St. Louis; Estados UnidosFil: Mostoslavsky, Raul. Harvard University; Estados UnidosPublic Library Of Science2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13660Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; et al.; SIRT6 is required for normal retinal function; Public Library Of Science; Plos One; 9; 6; 6-2014; 6-111932-6203enginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098831info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0098831info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24896097info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:47Zoai:ri.conicet.gov.ar:11336/13660instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:47.417CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
SIRT6 is required for normal retinal function |
title |
SIRT6 is required for normal retinal function |
spellingShingle |
SIRT6 is required for normal retinal function Silberman, Dafne Magali retina SIRT6 epigenetic |
title_short |
SIRT6 is required for normal retinal function |
title_full |
SIRT6 is required for normal retinal function |
title_fullStr |
SIRT6 is required for normal retinal function |
title_full_unstemmed |
SIRT6 is required for normal retinal function |
title_sort |
SIRT6 is required for normal retinal function |
dc.creator.none.fl_str_mv |
Silberman, Dafne Magali Ross, Kenneth Sande, Pablo H. Kubota, Shunsuke Ramaswamy, Sridhar Apte, Rajendra S. Mostoslavsky, Raul |
author |
Silberman, Dafne Magali |
author_facet |
Silberman, Dafne Magali Ross, Kenneth Sande, Pablo H. Kubota, Shunsuke Ramaswamy, Sridhar Apte, Rajendra S. Mostoslavsky, Raul |
author_role |
author |
author2 |
Ross, Kenneth Sande, Pablo H. Kubota, Shunsuke Ramaswamy, Sridhar Apte, Rajendra S. Mostoslavsky, Raul |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
retina SIRT6 epigenetic |
topic |
retina SIRT6 epigenetic |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin. Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados Unidos Fil: Ross, Kenneth. Harvard Medical School; Estados Unidos Fil: Sande, Pablo H.. Harvard Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Kubota, Shunsuke. Washington University in St. Louis; Estados Unidos Fil: Ramaswamy, Sridhar. Harvard Medical School; Estados Unidos Fil: Apte, Rajendra S.. Washington University in St. Louis; Estados Unidos Fil: Mostoslavsky, Raul. Harvard University; Estados Unidos |
description |
The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/13660 Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; et al.; SIRT6 is required for normal retinal function; Public Library Of Science; Plos One; 9; 6; 6-2014; 6-11 1932-6203 |
url |
http://hdl.handle.net/11336/13660 |
identifier_str_mv |
Silberman, Dafne Magali; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; et al.; SIRT6 is required for normal retinal function; Public Library Of Science; Plos One; 9; 6; 6-2014; 6-11 1932-6203 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098831 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0098831 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24896097 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Of Science |
publisher.none.fl_str_mv |
Public Library Of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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