Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.

Autores
Surkin, Pablo Nicolas; Brenhouse, H.; Deak, T.; Liberman, Ana Clara; Lasaga, Mercedes Isabel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, including the reproductive axis, the hypothalamic‐pituitary‐adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioural responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (perinatal, juvenile, adolescent periods) and how the developmental timing of early‐life stress confers unique physiological adaptations that may persist across the lifespan. In doing so, we emphasise how intrinsic sex differences in the stress response might contribute to sex‐specific vulnerabilities, the molecular processes underlying stress in the adult, and potential therapeutic interventions to mitigate the effects of early stage stress, including the novel molecular mechanism of SUMOylation as a possible key target of HPA regulation during early‐life stress.
Fil: Surkin, Pablo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Breanhouse H. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Deak T. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Liberman AC. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
ALCOHOL CONSUMPTION
HPA AXIS
IMMUNE CHALLENGE
MATERNAL SEPARATION
NEONATAL STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94634
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.Surkin, Pablo NicolasBrenhouse, H.Deak, T.Liberman, Ana ClaraLasaga, Mercedes IsabelALCOHOL CONSUMPTIONHPA AXISIMMUNE CHALLENGEMATERNAL SEPARATIONNEONATAL STRESShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, including the reproductive axis, the hypothalamic‐pituitary‐adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioural responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (perinatal, juvenile, adolescent periods) and how the developmental timing of early‐life stress confers unique physiological adaptations that may persist across the lifespan. In doing so, we emphasise how intrinsic sex differences in the stress response might contribute to sex‐specific vulnerabilities, the molecular processes underlying stress in the adult, and potential therapeutic interventions to mitigate the effects of early stage stress, including the novel molecular mechanism of SUMOylation as a possible key target of HPA regulation during early‐life stress.Fil: Surkin, Pablo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Breanhouse H. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Deak T. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Liberman AC. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaWiley Blackwell Publishing, Inc2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94634Surkin, Pablo Nicolas; Brenhouse, H.; Deak, T.; Liberman, Ana Clara; Lasaga, Mercedes Isabel; Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 10; 10-2018; 1-160953-8194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/jne.12602info:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12602info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:05Zoai:ri.conicet.gov.ar:11336/94634instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:06.048CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
title Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
spellingShingle Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
Surkin, Pablo Nicolas
ALCOHOL CONSUMPTION
HPA AXIS
IMMUNE CHALLENGE
MATERNAL SEPARATION
NEONATAL STRESS
title_short Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
title_full Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
title_fullStr Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
title_full_unstemmed Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
title_sort Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
dc.creator.none.fl_str_mv Surkin, Pablo Nicolas
Brenhouse, H.
Deak, T.
Liberman, Ana Clara
Lasaga, Mercedes Isabel
author Surkin, Pablo Nicolas
author_facet Surkin, Pablo Nicolas
Brenhouse, H.
Deak, T.
Liberman, Ana Clara
Lasaga, Mercedes Isabel
author_role author
author2 Brenhouse, H.
Deak, T.
Liberman, Ana Clara
Lasaga, Mercedes Isabel
author2_role author
author
author
author
dc.subject.none.fl_str_mv ALCOHOL CONSUMPTION
HPA AXIS
IMMUNE CHALLENGE
MATERNAL SEPARATION
NEONATAL STRESS
topic ALCOHOL CONSUMPTION
HPA AXIS
IMMUNE CHALLENGE
MATERNAL SEPARATION
NEONATAL STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, including the reproductive axis, the hypothalamic‐pituitary‐adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioural responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (perinatal, juvenile, adolescent periods) and how the developmental timing of early‐life stress confers unique physiological adaptations that may persist across the lifespan. In doing so, we emphasise how intrinsic sex differences in the stress response might contribute to sex‐specific vulnerabilities, the molecular processes underlying stress in the adult, and potential therapeutic interventions to mitigate the effects of early stage stress, including the novel molecular mechanism of SUMOylation as a possible key target of HPA regulation during early‐life stress.
Fil: Surkin, Pablo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Breanhouse H. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Deak T. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Liberman AC. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, including the reproductive axis, the hypothalamic‐pituitary‐adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioural responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (perinatal, juvenile, adolescent periods) and how the developmental timing of early‐life stress confers unique physiological adaptations that may persist across the lifespan. In doing so, we emphasise how intrinsic sex differences in the stress response might contribute to sex‐specific vulnerabilities, the molecular processes underlying stress in the adult, and potential therapeutic interventions to mitigate the effects of early stage stress, including the novel molecular mechanism of SUMOylation as a possible key target of HPA regulation during early‐life stress.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94634
Surkin, Pablo Nicolas; Brenhouse, H.; Deak, T.; Liberman, Ana Clara; Lasaga, Mercedes Isabel; Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 10; 10-2018; 1-16
0953-8194
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94634
identifier_str_mv Surkin, Pablo Nicolas; Brenhouse, H.; Deak, T.; Liberman, Ana Clara; Lasaga, Mercedes Isabel; Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 10; 10-2018; 1-16
0953-8194
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/jne.12602
info:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12602
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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