Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance

Autores
Vitale, Daiana Luján; Kumar Katakam, Sampath; Greve, Burkhard; Jang, Bohee; Oh, Eok Soo; Alaniz, Laura Daniela; Götte, Martin
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance proteins, active DNA repair capacity, apoptosis resistance, and a considerable developmental plasticity. Due to these properties, cancer stem cells display increased resistance to chemo- and radiotherapy. Recent findings indicate that aberrant functions of proteoglycans and glycosaminoglycans contribute substantially to the cancer stem cell phenotype and therapeutic resistance. In this review, we summarize how the diverse functions of the glycoproteins and carbohydrates facilitate acquisition and maintenance of the cancer stem cell phenotype, and how this knowledge can be exploited to develop novel anti-cancer therapies. For example, the large transmembrane chondroitin sulfate proteoglycan NG2 / CSPG4 marks stem cell populations in brain tumors. Cell surface heparan sulfate proteoglycans of the syndecan and glypican families modulate the stemness-associated Wnt, hedgehog and notch signaling pathways, whereas the interplay of hyaluronan in the stem cell niche with cancer stem cell CD44 determines maintenance of stemness and promotes therapeutic resistance. A better understanding of the molecular mechanisms by which proteoglycans and glycosaminoglycans regulate cancer stem cell function will aid the development of targeted therapeutic approaches which could avoid relapse after an otherwise successful conventional therapy. Chimeric antigen receptor T cells, proteoglycan-primed dendritic cells, proteoglycan-targeted antibody-drug conjugates and inhibitory peptides and glycans have already shown highly promising results in preclinical models.
Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Kumar Katakam, Sampath. Münster University Hospital; Alemania
Fil: Greve, Burkhard. Münster University Hospital; Alemania
Fil: Jang, Bohee. Ewha Womans University; Corea del Sur
Fil: Oh, Eok Soo. Ewha Womans University; Corea del Sur
Fil: Alaniz, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Götte, Martin. Münster University Hospital; Alemania
Materia
CANCER STEM CELL
HEPARAN SULFATE
HYALURONAN
CD44
SYNDECAN
CSPG4
STEM CELL NICHE
CHEMOTHERAPY
PROTEOGLYCAN
RADIATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123280
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123280
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistanceVitale, Daiana LujánKumar Katakam, SampathGreve, BurkhardJang, BoheeOh, Eok SooAlaniz, Laura DanielaGötte, MartinCANCER STEM CELLHEPARAN SULFATEHYALURONANCD44SYNDECANCSPG4STEM CELL NICHECHEMOTHERAPYPROTEOGLYCANRADIATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance proteins, active DNA repair capacity, apoptosis resistance, and a considerable developmental plasticity. Due to these properties, cancer stem cells display increased resistance to chemo- and radiotherapy. Recent findings indicate that aberrant functions of proteoglycans and glycosaminoglycans contribute substantially to the cancer stem cell phenotype and therapeutic resistance. In this review, we summarize how the diverse functions of the glycoproteins and carbohydrates facilitate acquisition and maintenance of the cancer stem cell phenotype, and how this knowledge can be exploited to develop novel anti-cancer therapies. For example, the large transmembrane chondroitin sulfate proteoglycan NG2 / CSPG4 marks stem cell populations in brain tumors. Cell surface heparan sulfate proteoglycans of the syndecan and glypican families modulate the stemness-associated Wnt, hedgehog and notch signaling pathways, whereas the interplay of hyaluronan in the stem cell niche with cancer stem cell CD44 determines maintenance of stemness and promotes therapeutic resistance. A better understanding of the molecular mechanisms by which proteoglycans and glycosaminoglycans regulate cancer stem cell function will aid the development of targeted therapeutic approaches which could avoid relapse after an otherwise successful conventional therapy. Chimeric antigen receptor T cells, proteoglycan-primed dendritic cells, proteoglycan-targeted antibody-drug conjugates and inhibitory peptides and glycans have already shown highly promising results in preclinical models.Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Kumar Katakam, Sampath. Münster University Hospital; AlemaniaFil: Greve, Burkhard. Münster University Hospital; AlemaniaFil: Jang, Bohee. Ewha Womans University; Corea del SurFil: Oh, Eok Soo. Ewha Womans University; Corea del SurFil: Alaniz, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Götte, Martin. Münster University Hospital; AlemaniaWiley Blackwell Publishing, Inc2019-06-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123280Vitale, Daiana Luján; Kumar Katakam, Sampath; Greve, Burkhard; Jang, Bohee; Oh, Eok Soo; et al.; Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance; Wiley Blackwell Publishing, Inc; Febs Journal; 286; 15; 23-6-2019; 2870-28821742-464X1432-1033CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14967info:eu-repo/semantics/altIdentifier/doi/10.1111/febs.14967info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:02:22Zoai:ri.conicet.gov.ar:11336/123280instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:02:23.058CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
title Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
spellingShingle Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
Vitale, Daiana Luján
CANCER STEM CELL
HEPARAN SULFATE
HYALURONAN
CD44
SYNDECAN
CSPG4
STEM CELL NICHE
CHEMOTHERAPY
PROTEOGLYCAN
RADIATION
title_short Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
title_full Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
title_fullStr Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
title_full_unstemmed Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
title_sort Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
dc.creator.none.fl_str_mv Vitale, Daiana Luján
Kumar Katakam, Sampath
Greve, Burkhard
Jang, Bohee
Oh, Eok Soo
Alaniz, Laura Daniela
Götte, Martin
author Vitale, Daiana Luján
author_facet Vitale, Daiana Luján
Kumar Katakam, Sampath
Greve, Burkhard
Jang, Bohee
Oh, Eok Soo
Alaniz, Laura Daniela
Götte, Martin
author_role author
author2 Kumar Katakam, Sampath
Greve, Burkhard
Jang, Bohee
Oh, Eok Soo
Alaniz, Laura Daniela
Götte, Martin
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER STEM CELL
HEPARAN SULFATE
HYALURONAN
CD44
SYNDECAN
CSPG4
STEM CELL NICHE
CHEMOTHERAPY
PROTEOGLYCAN
RADIATION
topic CANCER STEM CELL
HEPARAN SULFATE
HYALURONAN
CD44
SYNDECAN
CSPG4
STEM CELL NICHE
CHEMOTHERAPY
PROTEOGLYCAN
RADIATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance proteins, active DNA repair capacity, apoptosis resistance, and a considerable developmental plasticity. Due to these properties, cancer stem cells display increased resistance to chemo- and radiotherapy. Recent findings indicate that aberrant functions of proteoglycans and glycosaminoglycans contribute substantially to the cancer stem cell phenotype and therapeutic resistance. In this review, we summarize how the diverse functions of the glycoproteins and carbohydrates facilitate acquisition and maintenance of the cancer stem cell phenotype, and how this knowledge can be exploited to develop novel anti-cancer therapies. For example, the large transmembrane chondroitin sulfate proteoglycan NG2 / CSPG4 marks stem cell populations in brain tumors. Cell surface heparan sulfate proteoglycans of the syndecan and glypican families modulate the stemness-associated Wnt, hedgehog and notch signaling pathways, whereas the interplay of hyaluronan in the stem cell niche with cancer stem cell CD44 determines maintenance of stemness and promotes therapeutic resistance. A better understanding of the molecular mechanisms by which proteoglycans and glycosaminoglycans regulate cancer stem cell function will aid the development of targeted therapeutic approaches which could avoid relapse after an otherwise successful conventional therapy. Chimeric antigen receptor T cells, proteoglycan-primed dendritic cells, proteoglycan-targeted antibody-drug conjugates and inhibitory peptides and glycans have already shown highly promising results in preclinical models.
Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Kumar Katakam, Sampath. Münster University Hospital; Alemania
Fil: Greve, Burkhard. Münster University Hospital; Alemania
Fil: Jang, Bohee. Ewha Womans University; Corea del Sur
Fil: Oh, Eok Soo. Ewha Womans University; Corea del Sur
Fil: Alaniz, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Götte, Martin. Münster University Hospital; Alemania
description In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance proteins, active DNA repair capacity, apoptosis resistance, and a considerable developmental plasticity. Due to these properties, cancer stem cells display increased resistance to chemo- and radiotherapy. Recent findings indicate that aberrant functions of proteoglycans and glycosaminoglycans contribute substantially to the cancer stem cell phenotype and therapeutic resistance. In this review, we summarize how the diverse functions of the glycoproteins and carbohydrates facilitate acquisition and maintenance of the cancer stem cell phenotype, and how this knowledge can be exploited to develop novel anti-cancer therapies. For example, the large transmembrane chondroitin sulfate proteoglycan NG2 / CSPG4 marks stem cell populations in brain tumors. Cell surface heparan sulfate proteoglycans of the syndecan and glypican families modulate the stemness-associated Wnt, hedgehog and notch signaling pathways, whereas the interplay of hyaluronan in the stem cell niche with cancer stem cell CD44 determines maintenance of stemness and promotes therapeutic resistance. A better understanding of the molecular mechanisms by which proteoglycans and glycosaminoglycans regulate cancer stem cell function will aid the development of targeted therapeutic approaches which could avoid relapse after an otherwise successful conventional therapy. Chimeric antigen receptor T cells, proteoglycan-primed dendritic cells, proteoglycan-targeted antibody-drug conjugates and inhibitory peptides and glycans have already shown highly promising results in preclinical models.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123280
Vitale, Daiana Luján; Kumar Katakam, Sampath; Greve, Burkhard; Jang, Bohee; Oh, Eok Soo; et al.; Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance; Wiley Blackwell Publishing, Inc; Febs Journal; 286; 15; 23-6-2019; 2870-2882
1742-464X
1432-1033
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123280
identifier_str_mv Vitale, Daiana Luján; Kumar Katakam, Sampath; Greve, Burkhard; Jang, Bohee; Oh, Eok Soo; et al.; Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance; Wiley Blackwell Publishing, Inc; Febs Journal; 286; 15; 23-6-2019; 2870-2882
1742-464X
1432-1033
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14967
info:eu-repo/semantics/altIdentifier/doi/10.1111/febs.14967
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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